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Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.

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Τίτλος: Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.
Συγγραφείς: Liang L; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, PR China.; Department of Nephrology, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, PR China., Gu L; Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China., Shi L; Department of General Management, Jinan Blood Center, Jinan, PR China., Luo Q; Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China., Kong X; Department of Nephrology, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, PR China., Wang F; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, PR China.; Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China.
Πηγή: Renal failure [Ren Fail] 2026 Dec; Vol. 48 (1), pp. 2716956. Date of Electronic Publication: 2026 Sep 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE
Imprint Name(s): Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : M. Dekker, c1987-
Ιατρικοί όροι (MeSH): Kidney Failure, Chronic*/therapy , Neointima*/pathology , Neointima*/metabolism , Arteriovenous Shunt, Surgical*/adverse effects, Proteomics/methods ; Biomarkers/metabolism ; Biomarkers/analysis ; Veins/pathology ; Veins/metabolism ; Humans ; Hyperplasia ; Female ; Male ; Middle Aged ; Renal Dialysis ; Tandem Mass Spectrometry ; Aged ; Protein Interaction Maps
Περίληψη: Arteriovenous fistula (AVF) is the preferred vascular access for patients with end-stage renal disease; however, its failure is primarily due to neointimal hyperplasia. Five patients who underwent initial AVF surgery served as the control group, and another five patients with failed AVF surgery served as the experimental group. Herein, we employed mass spectrometry (MS)-based quantitative proteomics coupled with tandem mass tag labeling to screen differentially expressed proteins (DEPs) in the anastomotic cephalic vein, followed by bioinformatics analyses and verification experiments. A total of 121 DEPs were identified in the failed AVF group. GO analysis was primarily enriched in protein binding, nucleic acid binding, enzyme binding, mRNA binding, cadherin binding, catalytic activity, and cell adhesion molecule binding. KEGG pathways were mainly enriched in cell aggregation and adhesion, actin cytoskeleton, extracellular matrix-receptor interaction, PI3K-Akt signaling pathway, complement and coagulation cascades, and cholesterol metabolism. Protein-protein interaction network consisted of 86 (71.07%) DEPs, including complement VII (C7), factor IX (F9), SERPINC1, microfibril-associated glycoprotein 4 (MFAP4), complement C1s subcomponent, complement C1q subcomponent subunit A, complement C1q subcomponent subunit B, tissue factor, and von Willebrand factor, which interacting with numerous other proteins. In the expanded validation for different patients, C7, F9, SERPINC1, and MFAP4, were verified by immunohistochemical staining and Western blotting, which were consistent with the proteomics results. Collectively, this study identifies a series of potential diagnostic biomarkers, and explores the underlying mechanisms associated with AVF dysfunction.
References: JAMA Surg. 2021 Dec 1;156(12):1111-1118. (PMID: 34550312)
J Exp Med. 1981 Mar 1;153(3):665-76. (PMID: 7252410)
Circulation. 2017 Apr 25;135(17):1651-1664. (PMID: 28438806)
Nature. 2023 Oct;622(7984):834-841. (PMID: 37794190)
Am J Kidney Dis. 2020 Apr;75(4 Suppl 2):S1-S164. (PMID: 32778223)
Mol Med Rep. 2014 Jul;10(1):45-52. (PMID: 24789665)
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579. (PMID: 31278493)
Blood Purif. 2022;51(5):425-434. (PMID: 34320498)
Nat Aging. 2021 May;1(5):473-489. (PMID: 37118015)
Immunobiology. 2016 Jun;221(6):747-51. (PMID: 25956457)
Int J Nephrol Renovasc Dis. 2014 Jul 08;7:281-94. (PMID: 25045278)
Clin Exp Nephrol. 2020 Nov;24(11):1007-1014. (PMID: 32666345)
Osteoporos Int. 2019 May;30(5):1089-1098. (PMID: 30739146)
Clin Exp Ophthalmol. 2020 Aug;48(6):793-801. (PMID: 32356581)
JAMA Netw Open. 2020 Jun 1;3(6):e208035. (PMID: 32543701)
Int Immunopharmacol. 2026 May 15;177:116520. (PMID: 41865456)
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9346-E9355. (PMID: 29078321)
Int J Mol Sci. 2024 Sep 01;25(17):. (PMID: 39273465)
J Am Soc Nephrol. 2018 Nov;29(11):2735-2744. (PMID: 30309898)
Eur J Ophthalmol. 2020 Mar;30(2):315-320. (PMID: 30854895)
Rheumatology (Oxford). 2000 Feb;39(2):133-41. (PMID: 10725062)
Sci Total Environ. 2024 May 1;923:171457. (PMID: 38442751)
Cureus. 2025 Oct 23;17(10):e95213. (PMID: 41281131)
Arch Gynecol Obstet. 2018 Jun;297(6):1495-1501. (PMID: 29572748)
Circulation. 2006 Dec 19;114(25):2831-8. (PMID: 17145993)
Zhonghua Yi Xue Za Zhi. 2018 Nov 13;98(42):3406-3410. (PMID: 30440134)
JCI Insight. 2021 May 24;6(10):. (PMID: 34027892)
JAMA Intern Med. 2023 Apr 1;183(4):298-310. (PMID: 36804760)
Mol Immunol. 2008 Jun;45(11):3125-32. (PMID: 18452991)
Nat Commun. 2019 Oct 11;10(1):4621. (PMID: 31604910)
Lancet Glob Health. 2024 Mar;12(3):e382-e395. (PMID: 38365413)
Blood. 2019 Feb 7;133(6):511-520. (PMID: 30523120)
Year Immunol. 1989-1990;6:229-44. (PMID: 2701906)
Pediatr Nephrol. 2010 Aug;25(8):1409-18. (PMID: 19908070)
Int J Mol Sci. 2023 Jun 28;24(13):. (PMID: 37446003)
FASEB J. 2014 Jul;28(7):3171-82. (PMID: 24668752)
Adv Sci (Weinh). 2024 Mar;11(12):e2307022. (PMID: 38243847)
Mol Omics. 2022 Jul 11;18(6):555-567. (PMID: 35671090)
Semin Thromb Hemost. 2022 Mar;48(2):174-187. (PMID: 34428799)
Ann Vasc Surg. 2008 Jan;22(1):11-5. (PMID: 18055171)
Crit Rev Immunol. 1999;19(3):173-98. (PMID: 10422598)
Lancet. 2020 Feb 29;395(10225):709-733. (PMID: 32061315)
Cancer Cell. 2016 Nov 14;30(5):683-693. (PMID: 27746144)
Ren Fail. 2019 Nov;41(1):1036-1044. (PMID: 31814501)
Kidney Int Rep. 2023 Jan 17;8(4):837-850. (PMID: 37069981)
J Vasc Access. 2011 Jan-Mar;12(1):57-62. (PMID: 21038306)
Kidney Int. 2016 Feb;89(2):303-316. (PMID: 26806833)
Cochrane Database Syst Rev. 2021 Jul 23;7:CD002786. (PMID: 34298589)
Circ Heart Fail. 2021 Jul;14(7):e007849. (PMID: 34192899)
JAMA Intern Med. 2017 Feb 1;177(2):184-193. (PMID: 28055065)
Mol Immunol. 2007 Sep;44(16):3838-49. (PMID: 17768101)
Circ Res. 2023 Apr 14;132(8):950-969. (PMID: 37053277)
Nat Neurosci. 2021 Jun;24(6):810-817. (PMID: 33846625)
Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):438-41. (PMID: 22812254)
J Am Soc Nephrol. 2017 Oct;28(10):3076-3088. (PMID: 28724774)
Biomolecules. 2022 Feb 23;12(3):. (PMID: 35327539)
Eur J Vasc Endovasc Surg. 2017 Oct;54(4):513-522. (PMID: 28843984)
Am J Kidney Dis. 2025 Feb;85(2):236-252. (PMID: 39625430)
Molecules. 2024 Feb 16;29(4):. (PMID: 38398629)
Lancet Glob Health. 2020 Apr;8(4):e511-e523. (PMID: 32199120)
Bioengineering (Basel). 2020 Aug 06;7(3):. (PMID: 32781528)
J Proteomics. 2021 Jan 16;231:103995. (PMID: 33011346)
Nature. 2005 Dec 1;438(7068):612-21. (PMID: 16319881)
Am J Kidney Dis. 2021 Sep;78(3):369-379.e1. (PMID: 33857533)
Contributed Indexing: Keywords: End-stage renal disease; arteriovenous fistula; hemodialysis; neointimal hyperplasia; proteomics
Substance Nomenclature: 0 (Biomarkers)
Entry Date(s): Date Created: 20260907 Date Completed: 20260907 Latest Revision: 20260910
Update Code: 20260910
PubMed Central ID: PMC13552299
DOI: 10.1080/0886022X.2026.2716956
PMID: 42703036
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1525-6049
DOI:10.1080/0886022X.2026.2716956