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Tomographic and densitometric corneal alterations in asymptomatic offspring of patients with keratoconus: a Turkish cross-sectional study.

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Τίτλος: Tomographic and densitometric corneal alterations in asymptomatic offspring of patients with keratoconus: a Turkish cross-sectional study.
Συγγραφείς: Atesoglu HI; Ophthalmology Clinic, Birinci Eye Hospital, Cumhuriyet, Atatürk Boulevard, Nu:5, Beylikduzu, 34520, Istanbul, Turkey. h.ibrahim.atesoglu@gmail.com., Atesoglu MT; Department of Ophthalmology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey., Kızıltoprak H; Department of Ophthalmology Faculty of Medicine, Atlas University, Istanbul, Turkey., Kosekahya P; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Acar A; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Tekin K; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Πηγή: International ophthalmology [Int Ophthalmol] 2026 Sep 07; Vol. 46 (1). Date of Electronic Publication: 2026 Sep 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE
Imprint Name(s): Publication: Dordrecht : Kluwer
Original Publication: The Hague, Junk.
Ιατρικοί όροι (MeSH): Keratoconus*/diagnosis , Keratoconus*/epidemiology , Corneal Topography*/methods , Cornea*/pathology , Cornea*/diagnostic imaging , Densitometry*/methods, Turkey/epidemiology ; Humans ; Cross-Sectional Studies ; Female ; Male ; Adult ; Young Adult ; Adolescent ; ROC Curve ; Child ; Prevalence
Περίληψη: Purpose: To investigate Pentacam HR-derived topographic, topometric, tomographic, and corneal densitometric characteristics in asymptomatic offspring of patients with keratoconus and to determine the prevalence of keratoconus detected during screening in this high-risk population.
Methods: In this cross-sectional study, 56 offspring of patients with keratoconus and 60 age- and sex-matched healthy controls without a family history of keratoconus underwent comprehensive ophthalmic examination and Pentacam HR imaging. Participants diagnosed with keratoconus during screening were excluded from comparative analyses. Topographic, topometric, tomographic, and corneal densitometric parameters were compared between groups. Receiver operating characteristic (ROC) analysis was performed to evaluate the discriminatory performance of the examined parameters.
Results: Keratoconus was identified in 8 of 56 offspring (14.3%) during screening. After exclusion of these participants, 48 offspring and 60 controls were included in the final analysis. Offspring demonstrated significantly lower thinnest corneal thickness and significantly higher posterior elevation values compared with controls (all p < 0.05). Several Pentacam-derived indices, including ISV, IVA, IHA, IHD, Final D, PPI, and ART measurements, differed significantly between groups (all p < 0.05). Corneal densitometry values were significantly increased in the central 0-2 mm and 2-6 mm zones. Final D showed the highest diagnostic performance among tomographic indices (AUC = 0.862), whereas the anterior 0-2 mm densitometric measurement demonstrated the highest overall discriminative ability (AUC = 0.892).
Conclusions: Offspring of patients with keratoconus represent a high-risk population characterized by an increased prevalence of keratoconus and subtle tomographic, topometric, and densitometric corneal abnormalities despite clinically normal examinations. Pentacam HR-derived tomographic and densitometric parameters may facilitate early identification of individuals with increased ectatic susceptibility.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Competing of interests: The authors declare no competing interests.
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Contributed Indexing: Keywords: Corneal densitometry; Corneal tomography; Keratoconus; Offspring; Pentacam HR
Entry Date(s): Date Created: 20260907 Date Completed: 20260907 Latest Revision: 20260907
Update Code: 20260907
DOI: 10.1007/s10792-026-04259-5
PMID: 42702660
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-2630
DOI:10.1007/s10792-026-04259-5