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Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.

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Τίτλος: Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.
Συγγραφείς: Wang S; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA., Yang Y; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA., Sharp CJ; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA., Fareri D; Department of Psychology, Adelphi University, Garden City, NY, USA., Chein J; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA., Smith DV; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. Electronic address: david.v.smith@temple.edu.
Πηγή: Biological psychology [Biol Psychol] 2026 Oct; Vol. 210, pp. 109381. Date of Electronic Publication: 2026 Sep 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0375566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6246 (Electronic) Linking ISSN: 03010511 NLM ISO Abbreviation: Biol Psychol Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam, North-Holland.
Ιατρικοί όροι (MeSH): Trust*/psychology , Depression*/physiopathology , Depression*/diagnostic imaging , Depression*/psychology , Corpus Striatum*/diagnostic imaging , Corpus Striatum*/physiopathology , Reward* , Interpersonal Relations* , Brain* , Social Perception*, Friends/psychology ; Humans ; Male ; Female ; Magnetic Resonance Imaging ; Young Adult ; Adult ; Brain Mapping ; Adolescent
Περίληψη: Aim: Depression is associated with social dysfunction, but the mechanisms linking affective symptoms to disrupted close relationships remain understudied. It is also unclear whether neural sensitivity to shared reward predicts social valuation during more complex interactions, with the possibility of depression altering the link between how people experience rewards shared with and trust reciprocated by close others. Thus, this preregistered fMRI study tested whether neural sensitivity to shared reward cross-task predicts trust-related behavior and brain responses, and whether these associations depend on perceived closeness and depressive symptoms.
Methods: Participants completed a reward-sharing task and a Trust Game with a close friend, a stranger, and a computer. We measured striatal shared reward sensitivity (SRS; friend > computer) and tested whether it related to investment behavior and brain responses to trust reciprocation. Depressive symptoms and perceived closeness were assessed via self-report.
Results: In a final sample of n = 123, participants reporting more depressive symptoms invested more in their friend than in the computer. Striatal SRS predicted temporoparietal junction responses to reciprocated trust, but this association depended jointly on social closeness and depression - with depression reversing the expected pattern among individuals reporting closer relationships. Striatal SRS was also inversely associated with connectivity between the default mode network and cerebellum during reciprocity.
Conclusions: These findings suggest that closeness calibrates the striatal SRS' link to regional activity and network-level responses during social exchange, while depression alters how striatal SRS relates to regional activity, potentially disrupting how individuals interpret and respond to close others.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to disclose.
Σχόλια: Update of: bioRxiv. 2026 Mar 31:2026.03.27.714332. doi: 10.64898/2026.03.27.714332.. (PMID: 41958973)
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Grant Information: R01 AG067011 United States AG NIA NIH HHS; RF1 AG067011 United States AG NIA NIH HHS
Contributed Indexing: Keywords: Default Mode Network; Depression; Shared Reward; Social Closeness; Trust Game; Ventral Striatum
Entry Date(s): Date Created: 20260906 Date Completed: 20260919 Latest Revision: 20260926
Update Code: 20260926
PubMed Central ID: PMC13601942
DOI: 10.1016/j.biopsycho.2026.109381
PMID: 42702279
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-6246
DOI:10.1016/j.biopsycho.2026.109381