Academic Journal
Sex-dependent cortical responses to terpene-based olfactory stimulation revealed by EEG and sLORETA.
| Τίτλος: | Sex-dependent cortical responses to terpene-based olfactory stimulation revealed by EEG and sLORETA. |
|---|---|
| Συγγραφείς: | Ban Y; Department of GreenBio Science (BK21), Gyeongsang National University, Jinju 52828, the Republic of Korea; Division of Applied Life Science, Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: byr1218@naver.com., Park H; Department of GreenBio Science (BK21), Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: ejfjqsla123@naver.com., Yu SY; Department of GreenBio Science (BK21), Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: absdy0161@naver.com., Moon HS; Department of GreenBio Science (BK21), Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: mhs8420@naver.com., Kim SH; Division of Applied Life Science, Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: suhyun7042@naver.com., Kim JS; Agri-Food Bio Convergence Institute, Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: jisunkim79@gmail.com., Shin EC; Department of GreenBio Science (BK21), Gyeongsang National University, Jinju 52828, the Republic of Korea; Division of Applied Life Science, Gyeongsang National University, Jinju 52828, the Republic of Korea. Electronic address: eshin@gnu.ac.kr. |
| Πηγή: | Neuroscience letters [Neurosci Lett] 2026 Oct 30; Vol. 886, pp. 138727. Date of Electronic Publication: 2026 Sep 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| Ιατρικοί όροι (MeSH): | Terpenes*/pharmacology , Cerebral Cortex*/physiology , Olfactory Perception*/physiology , Smell*/physiology , Sex Characteristics*, Electroencephalography/methods ; Male ; Humans ; Female ; Odorants ; Adult ; Young Adult |
| Περίληψη: | Olfactory stimulation with volatile terpenes has been associated with modulation of human brain activity; however, sex-dependent neurophysiological responses to terpene-derived aromas remain unclear. This study investigated cortical responses to orange- and pine-derived terpene aromas using relative spectral power analysis of electroencephalography (EEG) rhythms and standardized low-resolution electromagnetic tomography (sLORETA). Volatile and odor-active compounds were characterized using an electronic nose (E-nose) and gas chromatography-mass spectrometry-olfactometry (GC-MS-O), indicating terpene-dominant profiles in both aroma samples. EEG recordings were obtained before, during, and after aroma inhalation. Significant sex-dependent differences in cortical responses were observed. In males, orange aroma induced significant increases in relative beta- and gamma-band power, particularly in the temporal and occipital regions. In females, pine aroma produced a significant increase in relative beta-band power, mainly in the frontal and occipital regions. sLORETA analysis further revealed distinct cortical activation patterns associated with aroma type and sex. These findings indicate that terpene-based olfactory stimulation differentially modulates cortical EEG responses in males and females, providing neurophysiological evidence for sex-dependent processing of olfactory stimuli. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: EEG; Olfactory stimulation; Sex differences; Terpenes; sLORETA |
| Substance Nomenclature: | 0 (Terpenes) |
| Entry Date(s): | Date Created: 20260904 Date Completed: 20261013 Latest Revision: 20261013 |
| Update Code: | 20261014 |
| DOI: | 10.1016/j.neulet.2026.138727 |
| PMID: | 42697505 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-7972 |
|---|---|
| DOI: | 10.1016/j.neulet.2026.138727 |