Proteins as Regulators of Metabolic Changes in Sepsis: Alterations in Body Fluids, Immune Cells, and Organs through the Eyes of Proteomics.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Proteins as Regulators of Metabolic Changes in Sepsis: Alterations in Body Fluids, Immune Cells, and Organs through the Eyes of Proteomics.
Συγγραφείς:	Leite GGF; Division of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo04039-032, Brazil.; National Science and Technology Institute for Precision Critical Care Medicine─INCT PCCM, Criciúma88806-000, Brazil., Dal-Pizzol F; National Science and Technology Institute for Precision Critical Care Medicine─INCT PCCM, Criciúma88806-000, Brazil.; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina88806-000, Brazil., van der Poll T; National Science and Technology Institute for Precision Critical Care Medicine─INCT PCCM, Criciúma88806-000, Brazil.; Centre for Infection and Molecular Medicine, Division of Infectious Diseases, Amsterdam University Medical Centre, Location AMC, University of Amsterdam, Amsterdam1105 AZ, The Netherlands., Salomão R; Division of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo04039-032, Brazil.; National Science and Technology Institute for Precision Critical Care Medicine─INCT PCCM, Criciúma88806-000, Brazil.
Πηγή:	Journal of proteome research [J Proteome Res] 2026 Sep 04; Vol. 25 (9), pp. 4380-4392.
Τύπος έκδοσης:	Journal Article; Review
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE
Imprint Name(s):	Original Publication: Washington, D.C. : American Chemical Society, c2002-
Ιατρικοί όροι (MeSH):	Sepsis/metabolism , Sepsis/immunology , Proteomics/methods , Body Fluids/metabolism , Proteome*/metabolism, Mitochondria/metabolism ; Humans ; Animals ; Metabolic Networks and Pathways ; Multiomics
Περίληψη:	Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection and profound metabolic alterations that contribute to immune dysfunction and organ failure. This Review synthesizes proteomic evidence on sepsis-associated alterations in proteins involved in metabolic pathways across circulating biofluids, immune cells, and organs. Across plasma and urine, proteomic studies identify disturbances in lipoprotein-associated pathways, redox homeostasis, mitochondrial function, and substrate metabolism, indicating that protein signatures of metabolic dysregulation are systemic and detectable across biofluids. In immune cells, monocytes and neutrophils, proteomic analyses reveal a shift toward glycolysis with concurrent impairment of mitochondrial pathways alongside phenotype-dependent differences in lipid and redox-related programs. Organ-level studies further show that metabolic responses are heterogeneous, with distinct trajectories in the kidney, heart, liver, lung, skeletal muscle, and brain. These observations support the concept that sepsis involves compartment-specific remodeling of metabolism-associated protein networks rather than a single convergent metabolic state. Proteomics also highlights potential translational opportunities by identifying metabolism-associated proteins linked to disease severity, clinical phenotypes, and biologically distinct patient subgroups, although the current evidence remains largely exploratory and context-dependent. Overall, proteomics provides a complementary framework for understanding the molecular regulation of sepsis-associated metabolic dysfunction and may refine biological stratification and therapeutic targeting, particularly when integrated with longitudinal sampling and multiomic data. (© 2026 The Authors. Published by American Chemical Society.)
Grant Information:	2025/20381-6 Funda????o de Amparo fi ls Pesquisa do Estado de S??o Paulo; 24/01786-2 Funda????o de Amparo fi ls Pesquisa do Estado de S??o Paulo; 408662/2024-7 Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico
Contributed Indexing:	Keywords: immunometabolism; lipoproteins; mitochondria and biomarkers
Substance Nomenclature:	0 (Proteome)
Entry Date(s):	Date Created: 20260904 Date Completed: 20260904 Latest Revision: 20260909
Update Code:	20260909
DOI:	10.1021/acs.jproteome.6c00386
PMID:	42695867
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1535-3907
DOI:	10.1021/acs.jproteome.6c00386