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ICAM-1 Hypomethylation Predicts Poor Prognosis in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

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Title: ICAM-1 Hypomethylation Predicts Poor Prognosis in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.
Authors: Xu MM; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Yao YX; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Lyu H; Department of Serve Liver Disease, Shandong Public Health Clinical Center of Shandong University, Jinan, Shandong, China., Qian Y; Department of Infectious Diseases, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China., Tian ZZ; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Fan YC; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China.; Hepatology Institute of Shandong University, Jinan, Shandong, China., Wang K; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China.; Hepatology Institute of Shandong University, Jinan, Shandong, China.
Source: Journal of medical virology [J Med Virol] 2026 Sep; Vol. 98 (9), pp. e71118.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Imprint Name(s): Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
MeSH Terms: Acute-On-Chronic Liver Failure*/mortality , Acute-On-Chronic Liver Failure*/diagnosis , Acute-On-Chronic Liver Failure*/virology , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/blood , Hepatitis B, Chronic*/complications , DNA Methylation*, Humans ; Prognosis ; Female ; Male ; Adult ; Promoter Regions, Genetic ; Middle Aged ; Leukocytes, Mononuclear ; Hepatitis B virus ; RNA, Messenger
Abstract: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with a high short-term mortality rate. Therefore, early and accurate prognostic prediction is crucial for precise clinical management. This study aims to investigate the expression patterns of intercellular adhesion molecule-1 (ICAM-1) and its predictive value for the short-term prognosis of patients with HBV-ACLF. The Methylight method was used to quantitatively detect ICAM-1 promoter methylation level in peripheral blood mononuclear cells (PMBCs) of 286 participants. Meanwhile, the mRNA and plasma expression levels of ICAM-1 were determined using RT-qPCR and ELISA, respectively. The ICAM-1 promoter methylation levels in PBMCs of HBV-ACLF patients were significantly lower than those in chronic hepatitis B (CHB) patients and healthy controls (HCs), whereas the mRNA and plasma expression levels of ICAM-1 were markedly elevated. The ICAM-1 methylation levels in HBV-ACLF patients correlated with specific clinical parameters. Among HBV-ACLF patients, ICAM-1 methylation levels were significantly lower in the non-survivor groups at both 28 and 90 days. The study further revealed that ICAM-1 methylation level serves as an independent influencing factor for the prognosis of HBV-ACLF patients at 28 and 90 days. Based on ROC curve and Kaplan-Meier curves, ICAM-1 methylation levels demonstrated excellent performance in predicting 28- and 90-day mortality in patients with HBV-ACLF. In conclusion, patients with HBV-ACLF exhibit hypomethylation of the ICAM-1 promoter. The combination of ICAM-1 promoter methylation level and MELD score can effectively enhance the predictive ability for the short-term prognosis of HBV-ACLF patients.
(© 2026 Wiley Periodicals LLC.)
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Grant Information: National Natural Science Foundation of China
Contributed Indexing: Keywords: DNA methylation; HBV‐ACLF; ICAM‐1; biomarkers; short‐term prognosis
Substance Nomenclature: 126547-89-5 (Intercellular Adhesion Molecule-1)
0 (ICAM1 protein, human)
0 (RNA, Messenger)
Entry Date(s): Date Created: 20260904 Date Completed: 20260904 Latest Revision: 20260906
Update Code: 20260906
PubMed Central ID: PMC13543333
DOI: 10.1002/jmv.71118
PMID: 42695456
Database: MEDLINE
Description
ISSN:1096-9071
DOI:10.1002/jmv.71118