Academic Journal
Megavoltage photon minibeam production through the embedded multi-leaf collimator of a clinical linac: A dosimetric characterization.
| Τίτλος: | Megavoltage photon minibeam production through the embedded multi-leaf collimator of a clinical linac: A dosimetric characterization. |
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| Συγγραφείς: | Linsalata S; UO Fisica Sanitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Pensavalle JH; S.I.T. - Sordina IORT Technologies S.p.A., Aprilia, Italy., Paiar F; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Romano F; Sezione di Catania, Istituto Nazionale di Fisica Nucleare (INFN), Catania, Italy., Traino AC; UO Fisica Sanitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Martino FD; UO Fisica Sanitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. |
| Πηγή: | Medical physics [Med Phys] 2026 Sep; Vol. 53 (9), pp. e70597. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics. |
| Ιατρικοί όροι (MeSH): | Particle Accelerators*/instrumentation , Photons*/therapeutic use , Radiometry*/instrumentation |
| Περίληψη: | Background: Although spatially-fractionated radiation therapy (SFRT) has been receiving increasing clinical interest, its complete and optimized clinical transfer requires several technological and radiobiological issues to be addressed. Purpose: The aim of this work is to setup and dosimetrically characterize an experimental platform generating planar megavoltage photon minibeams to exploit quantitative radiobiological SFRT experiments. Methods: Minibeam patterns were generated on a Varian TrueBeam™ linear accelerator equipped with a high definition (HD) MLC, which consists of 60 tungsten leaf pairs, whom the 32 inner ones project a thickness of 2.5 mm at the isocenter plane (i.e., 100 cm distance from the radiation source) and the 28 outers of 5 mm. Each pattern was obtained alternating opening one leaf after closing one, two, or three of the smallest MLC leaves. Measurements were performed with a PTW microdiamond detector in edge-on orientation in a water phantom over depths from 1 to 30 cm, varying the beam energy and the source to surface distance (SSD) in different sessions. A Python-based in-house automated fitting procedure was used to obtain from the measured profiles all the minibeam parameters: peak widths (PWs), distance between consecutive peaks (CTCs), peak to valley dose ratios (PVDRs) and depth doses. Results: The best performances were obtained at SSD = 70 cm and 6 MV, where PWs and PVDRs respectively range from 1.2 to 2.4 mm and from 2 to 7. For all patterns the average dose varies in depth analogously to the reference field, PVDRs show an almost steady decrease except at shallower depths, while PWs and CTCs widen linearly with the depths. Moreover, their variation over different sessions was within the estimated uncertainty of the single measurement. Conclusions: We are claiming that a Varian TrueBeam™ equipped with an HD-MLC represents a practical, stable, reproducible and accessible platform that might be suitable for radiobiological studies on SFRT and for the investigation of the relative underlying mechanisms. (© 2026 The Author(s). Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.) |
| References: | Phys Med Biol. 2024 May 10;69(10):. (PMID: 38648789) Cancers (Basel). 2020 Feb 25;12(3):. (PMID: 32106397) Br J Radiol. 2024 May 29;97(1158):1088-1098. (PMID: 38552328) Sci Rep. 2024 Feb 24;14(1):4510. (PMID: 38402259) Med Phys. 1992 Nov-Dec;19(6):1395-400. (PMID: 1461201) Phys Med. 2022 Aug;100:64-71. (PMID: 35750002) Med Phys. 2023 Aug;50(8):5222-5237. (PMID: 37145971) Med Phys. 2013 May;40(5):051712. (PMID: 23635260) J Appl Clin Med Phys. 2010 Apr 26;11(3):3163. (PMID: 20717082) Sci Rep. 2017 Dec 11;7(1):17295. (PMID: 29229965) J Appl Clin Med Phys. 2020 Aug;21(8):278-288. (PMID: 32441884) Med Phys. 2025 Feb;52(2):1224-1234. (PMID: 39504384) Phys Med Biol. 2015 Sep 7;60(17):6991-7005. (PMID: 26305166) Phys Med Biol. 2017 Nov 21;62(24):9260-9281. (PMID: 29053105) Phys Med. 2024 Aug;124:103420. (PMID: 38970950) Med Phys. 2012 Jul;39(7):4493-501. (PMID: 22830781) Med Phys. 2023 Jan;50(1):582-589. (PMID: 36004606) Clin Transl Radiat Oncol. 2019 Oct 22;20:30-38. (PMID: 31768424) Med Phys. 2006 Jan;33(1):76-82. (PMID: 16485412) Radiat Res. 2020 Dec 1;194(6):737-746. (PMID: 33064814) PLoS One. 2019 Sep 4;14(9):e0221454. (PMID: 31483811) Sci Rep. 2018 Nov 7;8(1):16479. (PMID: 30405188) Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):177-187. (PMID: 30684666) Sci Rep. 2019 May 3;9(1):6873. (PMID: 31053762) Int J Radiat Oncol Biol Phys. 2021 Feb 1;109(2):626-636. (PMID: 33038461) Med Phys. 2006 Sep;33(9):3165-73. (PMID: 17022209) J Appl Clin Med Phys. 2024 Aug;25(8):e14410. (PMID: 38810092) Med Phys. 2021 Oct;48(10):e886-e921. (PMID: 34101836) Int J Radiat Oncol Biol Phys. 2024 Dec 1;120(5):1423-1434. (PMID: 39002850) |
| Grant Information: | INFN-CSN5 2025-2027 National Institute for Nuclear Physics; 2022PLNN4F Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) |
| Contributed Indexing: | Keywords: SFRT; minibeam; photons |
| Entry Date(s): | Date Created: 20260904 Date Completed: 20260904 Latest Revision: 20260906 |
| Update Code: | 20260906 |
| PubMed Central ID: | PMC13542783 |
| DOI: | 10.1002/mp.70597 |
| PMID: | 42693776 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2473-4209 |
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| DOI: | 10.1002/mp.70597 |