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Mortality study of a PFOA-exposed cohort in the mid-Ohio Valley.

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Τίτλος: Mortality study of a PFOA-exposed cohort in the mid-Ohio Valley.
Συγγραφείς: Tan Y; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA., Hofmann JN; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Barry V; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA., Winquist A; Mercer School of Medicine, Columbus, GA, USA., Silverman DT; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Steenland K; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA USA. Electronic address: nsteenl@emory.edu.
Πηγή: Environment international [Environ Int] 2026 Sep; Vol. 215, pp. 110492. Date of Electronic Publication: 2026 Aug 30.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
Imprint Name(s): Publication: : Amsterdam : Elsevier Science
Original Publication: Oxford; Elmsford, N. Y., Pergamon Press.
Ιατρικοί όροι (MeSH): Caprylates*/blood , Fluorocarbons*/blood , Environmental Exposure*/statistics & numerical data , Environmental Pollutants*/blood, Ohio/epidemiology ; Neoplasms/mortality ; Humans ; Female ; Cohort Studies ; Male ; Middle Aged ; Adult ; Aged ; Cause of Death
Περίληψη: Background: The C8 Science Panel previously conducted studies of perfluorooctanoic acid (PFOA) exposure in Ohio Valley residents, finding probable links with kidney and testicular cancers, raised cholesterol, ulcerative colitis, thyroid disease, and pre-eclampsia. Findings were largely based on a cohort of 32,254 persons with high PFOA exposure followed through 2011 for disease incidence. We have now followed this cohort through 2021 for mortality.
Methods: Deaths were ascertained via the National Death Index (NDI). We extended cumulative PFOA serum estimates from 2011 until 2021. We used internal comparisons via Cox regression models to analyze cause-specific mortality for 22 causes of death in relation to natural log transformed cumulative PFOA exposure (continuous and in quartiles) with a variety of lags, controlling for confounders. We also considered multiple cause of death.
Results: There were 5709 deaths in the cohort through 2021. We found a positive significant trend (p < 0.05) in underlying cause of death analyses between the log cumulative serum level and brain cancer [HR 1.25 (1.05, 1.50)] and a suggestive but non-statistically significant association with bladder cancer [HR 1.17 (0.98, 1.39). . In stratified analysis, pancreatic cancer showed a positive significant trend among older participants (>72 years) [HR 1.23 (1.05, 1.43)]. No other causes showed marked positive trends, except for stroke among workers (13 % of total cohort).
Conclusion: PFOA exposure was significantly associated with mortality from brain cancer, and pancreatic cancer among older subjects. Pancreatic cancer has been associated with PFOA in animal studies, with equivocal evidence in other cohort studies. There was some suggestion of an increase of bladder cancer Caution is warranted due to multiple comparisons.
(Copyright © 2026. Published by Elsevier Ltd.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Grant Information: Z99 CA999999 United States ImNIH Intramural NIH HHS
Contributed Indexing: Keywords: Cancer; Mortality; PFOA
Substance Nomenclature: 0 (Caprylates)
947VD76D3L (perfluorooctanoic acid)
0 (Fluorocarbons)
0 (Environmental Pollutants)
Entry Date(s): Date Created: 20260903 Date Completed: 20260919 Latest Revision: 20261007
Update Code: 20261007
PubMed Central ID: PMC13639795
DOI: 10.1016/j.envint.2026.110492
PMID: 42691635
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-6750
DOI:10.1016/j.envint.2026.110492