Single-fiber reflectance spectroscopy system using unmodified clinical laser fibers for tissue optical property recovery for photodynamic therapy treatment planning.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Single-fiber reflectance spectroscopy system using unmodified clinical laser fibers for tissue optical property recovery for photodynamic therapy treatment planning.
Συγγραφείς:	Hannan MN; University of Rochester, Department of Physics and Astronomy, Rochester, New York, United States., Baran TM; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, United States.; University of Rochester, Department of Biomedical Engineering, Rochester, New York, United States.; University of Rochester, The Institute of Optics, Rochester, New York, United States.
Πηγή:	Journal of biomedical optics [J Biomed Opt] 2026 Sep; Vol. 31 (9), pp. 097001. Date of Electronic Publication: 2026 Sep 02.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society Country of Publication: United States NLM ID: 9605853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1560-2281 (Electronic) Linking ISSN: 10833668 NLM ISO Abbreviation: J Biomed Opt Subsets: MEDLINE
Imprint Name(s):	Original Publication: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society, c1996-
Ιατρικοί όροι (MeSH):	Photochemotherapy/methods , Spectrum Analysis/methods , Spectrum Analysis/instrumentation , Fiber Optic Technology/instrumentation , Optical Fibers*, Phantoms, Imaging ; Methylene Blue ; Humans ; Lasers ; Equipment Design
Περίληψη:	Significance: Estimation of tissue optical properties in workflow- and resource-constrained clinical settings is required to support photodynamic therapy (PDT) treatment planning, yet large-scale clinical translation remains limited by spectroscopy probe cost, complexity, and the need for probe-specific inverse models. Single-fiber reflectance (SFR) spectroscopy offers a simple and low-cost option, but previous implementations relied on customized angle-polished fibers. Aim: The objective was to develop a proof-of-concept SFR spectroscopy system employing an unmodified, United States Food and Drug Administration (FDA)-approved clinical optical fiber for quantitative optical property extraction. Approach: A semi-empirical photon pathlength model was used to recover the absorption spectra INLINEMATH and reduced scattering spectra INLINEMATH from tissue-mimicking phantoms containing methylene blue (MB) as the absorber and Intralipid-20% as the scatterer. Results: Optical property retrieval from measurements acquired using three nominally identical fibers demonstrated clinically sufficient accuracy across fibers without requiring model adaptation. Across all fibers, MB concentration INLINEMATH was recovered with a root mean square error (RMSE) of 0.6 to INLINEMATH ( INLINEMATH among fibers), while INLINEMATH was recovered with an RMSE of 1.5 to INLINEMATH ( INLINEMATH among fibers). Conclusions: We demonstrate the potential of SFR spectroscopy using a standard clinical optical fiber as a scalable and clinically useful tool for tissue optical property estimation to support PDT treatment planning. (© 2026 The Authors.)
Competing Interests:	The authors declare that there are no financial interests, commercial affiliations, or other potential conflicts of interest that could have influenced the objectivity of this research or the writing of this paper.
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Grant Information:	R01 EB029921 United States EB NIBIB NIH HHS
Contributed Indexing:	Keywords: Monte Carlo simulation; clinical optical fiber; inverse problem; optical property estimation; photodynamic therapy; single-fiber reflectance spectroscopy
Substance Nomenclature:	T42P99266K (Methylene Blue)
Entry Date(s):	Date Created: 20260903 Date Completed: 20260903 Latest Revision: 20260905
Update Code:	20260905
PubMed Central ID:	PMC13537727
DOI:	10.1117/1.JBO.31.9.097001
PMID:	42689265
Βάση Δεδομένων:	MEDLINE

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ISSN:	1560-2281
DOI:	10.1117/1.JBO.31.9.097001