Academic Journal
Targeting cellular senescence with Traditional Chinese Medicine: advances in neurodegenerative disorder treatment.
| Τίτλος: | Targeting cellular senescence with Traditional Chinese Medicine: advances in neurodegenerative disorder treatment. |
|---|---|
| Συγγραφείς: | Hai H; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Li M; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Hu X; Department of Oncology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Peng J; Department of Oncology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., He Z; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China. |
| Πηγή: | Frontiers in neurology [Front Neurol] 2026 Aug 19; Vol. 17, pp. 1875385. Date of Electronic Publication: 2026 Aug 19 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Review; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-2295 (Electronic) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation, 2010]- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Medicine, Chinese Traditional*/methods , Drugs, Chinese Herbal*/therapeutic use , Drugs, Chinese Herbal*/pharmacology, Signal Transduction/drug effects ; Humans ; Animals |
| Περίληψη: | Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent formidable health challenges, particularly within aging populations. Cellular senescence, marked by irreversible cell cycle arrest and the secretion of pro-inflammatory cytokines, has emerged as a crucial factor in the pathogenesis of these disorders. The accumulation of senescent cells in the nervous system exacerbates neuroinflammation, impairs neuronal function, and accelerates tissue degeneration, all of which are key features of NDDs. In this context, bioactive components derived from Traditional Chinese Medicine (TCM) have attracted significant attention for their potential to modulate cellular senescence and alleviate neurodegeneration. This review examines the shared molecular signaling pathways linking cellular senescence to NDDs, explores the mechanisms by which TCM-derived compounds-such as ginsenosides, ginkgo biloba extract, and curcumin-intervene in senescence-related processes, and discusses the translational potential of these natural compounds for clinical application. (Copyright © 2026 Hai, Li, Hu, Peng and He.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: Traditional Chinese Medicine; active components; cellular senescence; neurodegenerative diseases; signaling pathways; therapeutic potential |
| Substance Nomenclature: | 0 (Drugs, Chinese Herbal) |
| Entry Date(s): | Date Created: 20260903 Date Completed: 20260903 Latest Revision: 20260904 |
| Update Code: | 20260904 |
| PubMed Central ID: | PMC13533672 |
| DOI: | 10.3389/fneur.2026.1875385 |
| PMID: | 42687999 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1664-2295 |
|---|---|
| DOI: | 10.3389/fneur.2026.1875385 |