Academic Journal
Personalized curved-backing microneedles with amphotericin B-loaded nanoparticles for fungal keratitis treatment.
| Τίτλος: | Personalized curved-backing microneedles with amphotericin B-loaded nanoparticles for fungal keratitis treatment. |
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| Συγγραφείς: | Shen S; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China., Wang L; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China., Li Y; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China., Wan A; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China., Weng J; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Institute of Laser Advanced Manufacturing, Zhejiang University of Technology, Hangzhou 310023, P. R. China.; College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, P. R. China., Xie B; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China., She Y; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China., David L; Université Lyon 1, INSA Lyon, Université Jean Monnet, CNRS, UMR 5223, Ingénierie des Matériaux Polymères, F-69622 Villeurbanne, France., Feng L; Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School, Shanghai 200011, P. R. China. 119112@sh9hospital.org.cn., Yan Q; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yqy@zjut.edu.cn.; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. |
| Πηγή: | Journal of materials chemistry. B [J Mater Chem B] 2026 Sep 23; Vol. 14 (36), pp. 11248-11262. Date of Electronic Publication: 2026 Sep 23. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Royal Society of Chemistry |
| Ιατρικοί όροι (MeSH): | Nanoparticles*/chemistry , Amphotericin B*/chemistry , Amphotericin B*/pharmacology , Amphotericin B*/therapeutic use , Amphotericin B*/administration & dosage , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/therapeutic use , Keratitis*/drug therapy , Keratitis*/microbiology , Eye Infections, Fungal*/drug therapy, Candida albicans/drug effects ; Polyesters/chemistry ; Animals ; Rabbits ; Microneedle Drug Delivery ; Needles |
| Περίληψη: | Fungal keratitis (FK) is a severe ocular infection that often leads to vision impairment, yet its clinical management remains challenging due to poor drug bioavailability from conventional eye drops and tissue damage risks associated with intraocular injections. Microneedles (MNs) offer a minimally invasive alternative for corneal drug delivery, but conventional designs cause pain, structural damage, and reduced corneal transparency. Herein, we report a finite element simulation-assisted strategy to fabricate personalized curved-backing microneedles with a curvature-matched backing that ensures conformal surface contact, controlled penetration depth, and uniform drug distribution, effectively overcoming the limitations of conventional MNs. To enhance drug delivery, amphotericin B, a hydrophobic antifungal agent, was encapsulated in poly(lactic acid) nanoparticles, achieving improved solubility and sustained release. In vitro and in vivo short-term evaluations demonstrated that this integrated system effectively inhibited C. albicans growth and promoted corneal repair in a rabbit model of FK, without inducing significant ocular irritation or structural damage over the 14-day observation period. Our design strategy offers a viable approach to addressing barriers associated with corneal drug delivery. |
| Substance Nomenclature: | 7XU7A7DROE (Amphotericin B) 0 (Antifungal Agents) 459TN2L5F5 (poly(lactide)) 0 (Polyesters) |
| Entry Date(s): | Date Created: 20260903 Date Completed: 20260923 Latest Revision: 20260923 |
| Update Code: | 20260923 |
| DOI: | 10.1039/d6tb01241h |
| PMID: | 42687816 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2050-7518 |
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| DOI: | 10.1039/d6tb01241h |