Academic Journal
Wearable Colorimetric Microfluidic Sensor Integrated with Localized Unidirectional Sweat-Wicking Nanofiber Membrane for Multianalyte Sweat Analysis.
| Τίτλος: | Wearable Colorimetric Microfluidic Sensor Integrated with Localized Unidirectional Sweat-Wicking Nanofiber Membrane for Multianalyte Sweat Analysis. |
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| Συγγραφείς: | Lan W; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China., Qiu Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China., Ye Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China., Chen Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China., Chen X; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China., Wang W; School of Mechanical and Electrical Engineering, Guangzhou University, Guangzhou510006, China., Tang Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou510006, China. |
| Πηγή: | ACS sensors [ACS Sens] 2026 Aug 28; Vol. 11 (8), pp. 7455-7467. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Chemical Society, [2016]- |
| Ιατρικοί όροι (MeSH): | Sweat*/chemistry , Colorimetry*/instrumentation , Colorimetry*/methods , Nanofibers*/chemistry , Microfluidic Analytical Techniques*/instrumentation , Microfluidic Analytical Techniques*/methods , Biosensing Techniques*/instrumentation , Wearable Electronic Devices* , Lab-On-A-Chip Devices*, Glucose/analysis ; Urea/analysis ; Chlorides/analysis ; Humans ; Membranes, Artificial |
| Περίληψη: | Wearable sweat sensors have emerged as promising platforms for noninvasive health monitoring; however, inefficient sweat collection and uncontrolled fluid transport remain major challenges that limit their practical application. Here, we report a wearable colorimetric microfluidic sweat sensor integrated with a localized Janus TPU nanofiber membrane (CMS-LJNM) that enables efficient sweat collection and directional transport. The Janus membrane, featuring patterned hydrophilic-hydrophobic regions, facilitates passive and rapid unidirectional sweat transport from the skin surface to the microfluidic chip while suppressing lateral spreading. The flexible microfluidic chip incorporates capillary burst valves to precisely regulate sweat flow and prevent cross-contamination between sensing chambers. The device integrates multiple colorimetric sensing units for the simultaneous quantification of key sweat biomarkers, including glucose, urea, chloride ions, and pH, requiring only 2 μL of sweat for complete analysis. All sensing units exhibited good linearity within physiological concentration ranges and excellent anti-interference performance, and the results could be conveniently quantified through smartphone-based image analysis. On-body tests involving six volunteers demonstrated reliable sweat collection and detection, with results showing strong agreement with conventional analytical methods. This work provides a promising strategy integrating efficient directional sweat transport with precise microfluidic-based multianalyte detection, facilitating practical sports monitoring and sweat-based physiological analysis. (© 2026 American Chemical Society.) |
| Grant Information: | 2025A04J7082 Guangzhou Municipal Science and Technology Project |
| Contributed Indexing: | Keywords: Janus nanofiber membrane; colorimetric sensing; microfluidic chip; unidirectional sweat transport; wearable sweat sensor |
| Substance Nomenclature: | IY9XDZ35W2 (Glucose) 8W8T17847W (Urea) 0 (Chlorides) 0 (Membranes, Artificial) |
| Entry Date(s): | Date Created: 20260903 Date Completed: 20260903 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| DOI: | 10.1021/acssensors.6c01873 |
| PMID: | 42687270 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2379-3694 |
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| DOI: | 10.1021/acssensors.6c01873 |