Academic Journal
Sex-specific physical activity thresholds influencing muscle function in older adults with XX genotype of ACTN3 R577X.
| Τίτλος: | Sex-specific physical activity thresholds influencing muscle function in older adults with XX genotype of ACTN3 R577X. |
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| Συγγραφείς: | Hsu HC; Graduate Institute of Medical Sciences, College of Medicine, National Defence Medical University, Taipei City, Taiwan., Fang WH; Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan., Lee MC; Graduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan., Chen WT; Division of Thoracic Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei City, Taiwan., Chen YH; Graduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan., Lin HT; Graduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan., Wang CC; Department of Orthopedics, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan., Lin SB; Tri-Service General Hospital Songshan Branch, Taipei City, Taiwan., Chen CJ; Department of Surgery, Chiayi Branch, Taichung Veterans General Hospital, Chiayi City, Taiwan., Chen MJ; Department of Nursing, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan., Su SL; Graduate Institute of Medical Sciences, College of Medicine, National Defence Medical University, Taipei City, Taiwan. a131419@gmail.com.; Graduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan. a131419@gmail.com. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Sep 03; Vol. 16 (1). Date of Electronic Publication: 2026 Sep 03. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Actinin*/genetics , Muscle, Skeletal*/physiology , Exercise*/physiology , Sarcopenia*/genetics , Sarcopenia*/physiopathology, Hand Strength/physiology ; Humans ; Female ; Aged ; Genotype ; Male ; Aged, 80 and over ; Sex Factors |
| Περίληψη: | Physical activity is widely recommended to maintain muscle health in older adults, yet its effects may vary depending on genetic background. The ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in XX homozygotes and may influence skeletal muscle performance. We examined the association between physical activity and muscle mass and function in 682 community-dwelling adults aged ≥ 65 years who participated in annual health examinations between 2021 and 2024. Skeletal muscle mass index was assessed using dual-energy X-ray absorptiometry, while grip strength, gait speed, and five-time chair stand performance were evaluated according to Asian Working Group for Sarcopenia criteria. Physical activity was quantified using metabolic equivalents derived from the International Physical Activity Questionnaire. No significant association was observed between ACTN3 R577X genotype and sarcopenia components. However, in women with ACTN3 XX, physical activity exceeding 441 MET-min/week was significantly associated with poorer chair stand performance (β: 4.19, 95% CI: 0.98 ~ 7.40), revealing a U-shaped relationship between physical activity and physical performance. Sex-specific physical activity thresholds may exist in older adults with the ACTN3 XX genotype, with physical activity above 441 MET-min/week being associated with poorer muscle function in women. This specific MET value is an exploratory finding, requiring more external validation. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
| References: | Bone. 2019 Jun;123:137-144. (PMID: 30930293) Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:52-60. (PMID: 24450561) J Muscle Res Cell Motil. 1989 Aug;10(4):280-9. (PMID: 2671039) J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1227-34. (PMID: 19038838) PLoS One. 2021 Mar 4;16(3):e0247617. (PMID: 33661964) BMJ Open. 2024 Nov 5;14(11):e087064. (PMID: 39500605) J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):451-6. (PMID: 438011) Eur J Intern Med. 2019 Mar;61:e9. (PMID: 30448033) Exp Gerontol. 2020 Mar;131:110801. (PMID: 31887347) Age (Dordr). 2013 Oct;35(5):1949-59. (PMID: 22855367) Clin Interv Aging. 2017 May 17;12:835-845. (PMID: 28553092) J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. (PMID: 32033882) J Clin Endocrinol Metab. 2016 Jun;101(6):2450-9. (PMID: 27144936) Br J Sports Med. 2026 Jun 12;60(12):844-847. (PMID: 42091214) J Neurol Sci. 1988 Apr;84(2-3):275-94. (PMID: 3379447) Int J Sports Med. 2010 Apr;31(4):221-4. (PMID: 20148371) Endocrinol Metab (Seoul). 2024 Jun;39(3):521-530. (PMID: 38858821) Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Mar;25(3):265-8. (PMID: 15200945) Aging Male. 2017 Sep;20(3):168-169. (PMID: 28414253) Int J Biochem Cell Biol. 2013 Oct;45(10):2163-72. (PMID: 23806868) J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):3-19. (PMID: 29151281) Gerontology. 2019;65(6):686-698. (PMID: 31499496) Nucleic Acids Res. 2025 Jan 6;53(D1):D948-D957. (PMID: 39656687) Science. 2020 Sep 11;369(6509):1318-1330. (PMID: 32913098) Am J Clin Nutr. 2007 May;85(5):1344-52. (PMID: 17490972) Metabolism. 1997 Apr;46(4):410-3. (PMID: 9109845) J Physiol. 2023 Feb;601(3):419-434. (PMID: 34762308) Age Ageing. 2020 Feb 27;49(2):300-304. (PMID: 31728486) Exp Gerontol. 2018 Oct 2;112:38-43. (PMID: 30179662) Biomed Res Int. 2017;2017:4239648. (PMID: 28626757) Int J Environ Res Public Health. 2020 Feb 14;17(4):. (PMID: 32075076) J Gerontol A Biol Sci Med Sci. 2000 Jan;55(1):B49-53. (PMID: 10719763) Curr Protoc Hum Genet. 2009 Jan;Chapter 2:Unit 2.12. (PMID: 19170031) Scand J Med Sci Sports. 2017 Dec;27(12):1537-1546. (PMID: 27882617) J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):206-12. (PMID: 17339648) BMJ Open. 2015 Sep 15;5(9):e008542. (PMID: 26373405) Phys Ther. 2005 Oct;85(10):1034-45. (PMID: 16180952) Obes Res. 2005 Feb;13(2):312-9. (PMID: 15800289) Int J Behav Nutr Phys Act. 2011 Oct 21;8:115. (PMID: 22018588) Am J Clin Nutr. 2004 Sep;80(3):752-8. (PMID: 15321818) Exp Gerontol. 2021 Oct 15;154:111525. (PMID: 34425205) Clin Interv Aging. 2020 Jun 10;15:877-878. (PMID: 32606627) Clin Interv Aging. 2010 Sep 07;5:217-28. (PMID: 20852669) J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):412-419. (PMID: 29546320) J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:11-6. (PMID: 7493202) Gerontology. 2007;53(6):404-10. (PMID: 17700027) Physiol Rev. 2011 Oct;91(4):1447-531. (PMID: 22013216) Geriatr Gerontol Int. 2025 Feb;25(2):173-181. (PMID: 39716452) Sports Med. 2004;34(12):809-24. (PMID: 15462613) Metab Syndr Relat Disord. 2026 Feb;24(1):17-25. (PMID: 41060832) J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):828-834. (PMID: 28977377) Neuromuscul Disord. 1996 Aug;6(4):229-35. (PMID: 8887951) J Phys Ther Sci. 2016 Oct;28(10):2731-2736. (PMID: 27821924) Bonekey Rep. 2012 Apr 04;1:58. (PMID: 27127623) |
| Grant Information: | CHNDMC-113-11201 Cheng Hsin General Hospital Foundation; TSGH_D_113119 Tri-Service General Hospital; RVHCY113012 Chiayi Branch, Taichung Veterans General Hospital, Taiwan; TSGH-SS_E_113017 Tri-Service General Hospital Songshan Branch; MOST111-2314-B016-011 Ministry of Science and Technology, Taiwan; NSTC112-2314-B-016-037 National Science and Technology Council |
| Contributed Indexing: | Keywords: ACTN3 R577X polymorphism; Aging; Muscle function; Physical activity; Sex differences |
| Substance Nomenclature: | 11003-00-2 (Actinin) 0 (ACTN3 protein, human) |
| Entry Date(s): | Date Created: 20260903 Date Completed: 20260903 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13538621 |
| DOI: | 10.1038/s41598-026-57340-5 |
| PMID: | 42686826 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-026-57340-5 |