Academic Journal
Mangiferin attenuates UV-B-induced premature senescence through suppression of mitochondrial ROS and restoration of mitochondrial dynamics in human dermal fibroblasts and BALB/c mice.
| Τίτλος: | Mangiferin attenuates UV-B-induced premature senescence through suppression of mitochondrial ROS and restoration of mitochondrial dynamics in human dermal fibroblasts and BALB/c mice. |
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| Συγγραφείς: | Ragni G; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mushtaq MA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Irshad BA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Farhat KN; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Kaiser P; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Zabeer A; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Tasduq SA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: stabdullah@iiim.res.in. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Oct 15; Vol. 182, pp. 110454. Date of Electronic Publication: 2026 Aug 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Ultraviolet Rays*/adverse effects , Reactive Oxygen Species*/metabolism , Reactive Oxygen Species*/antagonists & inhibitors , Mitochondria*/drug effects , Mitochondria*/metabolism , Fibroblasts*/drug effects , Fibroblasts*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/radiation effects , Xanthones*/pharmacology , Xanthones*/chemistry , Mitochondrial Dynamics*/drug effects, Skin Aging/drug effects ; Skin/drug effects ; Humans ; Animals ; Mice ; Mice, Inbred BALB C ; Dose-Response Relationship, Drug ; Cells, Cultured ; Molecular Structure ; Structure-Activity Relationship |
| Περίληψη: | Human skin is continuously exposed to harmful Ultraviolet Radiations from the Sun leading to various morphological (pigmentation, sun burn, loss of elasticity and wrinkling) and physiological (ROS generation, oxidative stress, inflammation, DNA damage and cell death) alterations. All these changes make skin more susceptible to skin aging out of which cellular senescence plays a major role in UV-B driven skin aging. Senescence is the phenomenon of cell cycle arrest associated with changes at morphological and cellular levels i.e. compromised nuclear integrity, dysfunctional mitochondria producing excessive ROS, release of certain proinflammatory cytokines (SASP) which establish paracrine senescence in the neighboring cells. SASP is associated with the release of extracellular matrix metalloproteinases which break down the collagen fibres driving skin towards premature aging. In this study, we have unravelled the role of Mangiferin, a xanthonoid, in preventing UV-B induced premature senescence in HDF cells and BALB/c mice. Xanthonoids are a group of polyphenolic compounds known to possess cytoprotective, anti-inflammatory and antioxidant activities. Many xanthonoids including Mangiferin (MGN) are known to alleviate mitochondrial ROS production. As mitochondrial ROS is a key driver of cellular senescence in UV-B irradiated HDF cells, we have studied the role of Mangiferin in preventing/ attenuating the premature senescence in UV-B exposed HDF cells by inhibiting mitochondrial ROS production. Mangiferin significantly inhibited premature senescence in skin by quenching mitochondrial ROS production. And topical application of Mangiferin on BALB/c mice showed reduced signs of Photodamage and senescence, implying that it has potential to be developed as therapeutic agent for UV-B driven premature senescence induced photoaging in skin dermal cells. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Mangiferin; Mitochondrial ROS and mitochondrial dynamics; Skin fibroblasts; Stress induced premature senescence; Ultraviolet radiation |
| Substance Nomenclature: | 1M84LD0UMD (mangiferin) 0 (Reactive Oxygen Species) 0 (Xanthones) |
| Entry Date(s): | Date Created: 20260901 Date Completed: 20261008 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1016/j.bioorg.2026.110454 |
| PMID: | 42679742 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.110454 |