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Monocyte-derived galectin-1hi cells provide innate immune help in the generation of functional memory CD8+ T cells.

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Τίτλος: Monocyte-derived galectin-1hi cells provide innate immune help in the generation of functional memory CD8+ T cells.
Συγγραφείς: Lim K; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA. kihong_lim@urmc.rochester.edu., Dahal A; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA., Lv X; Department of Pediatrics, University of Rochester, Rochester, NY, USA., Kim KD; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.; Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI), Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea., Evans BA; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA., Li H; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA., Steiner LA; Department of Pediatrics, University of Rochester, Rochester, NY, USA., Kim M; Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA. minsoo_kim@urmc.rochester.edu.
Πηγή: Nature immunology [Nat Immunol] 2026 Oct; Vol. 27 (10), pp. 2102-2116. Date of Electronic Publication: 2026 Aug 31.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, NY : Nature America Inc. c2000-
Ιατρικοί όροι (MeSH): CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Galectin 1*/metabolism , Galectin 1*/immunology , Monocytes*/immunology , Monocytes*/metabolism , Orthomyxoviridae Infections*/immunology , Memory T Cells*/immunology , Immunologic Memory* , Immunity, Innate*, Receptors, CCR2/metabolism ; Receptors, CCR2/genetics ; Lung/immunology ; Lung/virology ; Influenza Vaccines/immunology ; Influenza Vaccines/administration & dosage ; Transforming Growth Factor beta/metabolism ; Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Cell Differentiation ; Mice, Knockout
Περίληψη: After viral infections, tissue-resident memory T cells (TRM cells) are generated and reactivated rapidly upon re-exposure to previously encountered viral pathogens, providing immediate immune effector functions to limit infection at the site of viral entry. Here we found that a subset of newly recruited CCR2+ monocytes differentiated into memory-stage CCR2-tdTomato+ cells and persisted in the lung for more than 4 months after infection with the influenza virus. Selective depletion of the memory-stage CCR2-tdTomato+ cells reduced significantly the formation of lung CD8+ TRM cells and compromised secondary heterosubtypic immune protection. Memory-stage CCR2-tdTomato+ cells colocalized with lung CD8+ TRM cells and secreted galectin-1, which activated CD8+ T cells directly and enhanced transforming growth factor-β sensing. Intranasal administration of recombinant galectin-1 as an adjuvant for the influenza vaccine induced superior memory CD8+ T cell responses. Thus, the presence of a unique memory-like monocyte-derived subset provided crucial signals to establish and maintain functional CD8+ TRM cells in the lung.
(© 2026. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Competing Interests: Competing interests: The authors declare no competing interests.
Σχόλια: Erratum in: Nat Immunol. 2026 Oct 13. doi: 10.1038/s41590-026-02704-2.. (PMID: 42870045)
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Grant Information: AI102851 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID); AI187088 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID); AI 187071 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID); HL160723 U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI); HL173979 U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI); GM007356 U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS); DK124777 U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases); RS-2024-00342560 National Research Foundation of Korea (NRF)
Substance Nomenclature: 0 (Galectin 1)
0 (Receptors, CCR2)
0 (Ccr2 protein, mouse)
0 (Influenza Vaccines)
0 (Lgals1 protein, mouse)
0 (Transforming Growth Factor beta)
Entry Date(s): Date Created: 20260831 Date Completed: 20261002 Latest Revision: 20261013
Update Code: 20261014
DOI: 10.1038/s41590-026-02638-9
PMID: 42675114
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1529-2916
DOI:10.1038/s41590-026-02638-9