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Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.

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Τίτλος: Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.
Συγγραφείς: Ipata AE; Department of Neuroscience, Columbia University, New York, New York 10027 ai2019@columbia.edu vf226@columbia.edu.; Mahoney Center for Brain and Behavior Research, Columbia University, New York, New York 10027., Fascianelli V; Center for Theoretical Neuroscience, Columbia University, New York, New York 10027 ai2019@columbia.edu vf226@columbia.edu.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., De Zeeuw CI; Department of Neuroscience, Erasmus MC, Rotterdam 3015, The Netherlands.; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Science (KNAW), Amsterdam 1105, The Netherlands., Sendhilnathan N; Department of Neuroscience, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., Fusi S; Department of Neuroscience, Columbia University, New York, New York 10027.; Center for Theoretical Neuroscience, Columbia University, New York, New York 10027.; Kavli Institute for Brain Science, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., Goldberg ME; Department of Neuroscience, Columbia University, New York, New York 10027.; Mahoney Center for Brain and Behavior Research, Columbia University, New York, New York 10027.; Kavli Institute for Brain Science, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027.; Department of Neurology, Psychiatry, and Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York 10027.
Πηγή: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Oct 07; Vol. 46 (40). Date of Electronic Publication: 2026 Oct 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Imprint Name(s): Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
Ιατρικοί όροι (MeSH): Purkinje Cells*/physiology , Psychomotor Performance*/physiology , Choice Behavior*/physiology , Association Learning*/physiology , Reinforcement, Psychology*, Action Potentials/physiology ; Animals ; Male ; Photic Stimulation ; Macaca mulatta
Περίληψη: Evidence implicates the cerebellum in motor learning and performance and relatively simple sensorimotor associations such as classical conditioning. However, little is known about how Purkinje cells encode more complex associations, such as arbitrary stimulus-response mappings. To address this, we recorded from Crus I/II Purkinje cells while two male macaques learned to associate novel fractal cues with left- or right-hand bar release. Here we show that as learning progresses, the simple spike activity of individual neurons becomes more selective for stimulus-response associations, with selectivity for left or right association developing closer to the appearance of visual stimuli. Initially, most neurons respond to both associations, irrespective of the identity of the stimulus and the associated movement, but as learning advances, more neurons distinguish between specific stimulus-hand associations. Moreover, complex spikes, which respond after the appearance of the stimuli, decrease their activity as the monkeys learn the task, suggesting that climbing-fiber activity encodes higher-order sensorimotor associations beyond mere error signaling. Using a linear decoder, we found that in early learning stages, the visual stimulus can be decoded only when the choice can also be decoded. As learning progresses, the visual stimulus is decoded earlier than the choice. A simple model can replicate the observed Purkinje cell signals in both the early and late learning stages.
(Copyright © 2026 Ipata et al.)
Competing Interests: The authors declare no competing financial interests.
Σχόλια: Update of: bioRxiv. 2024 Sep 15:2024.09.13.612926. doi: 10.1101/2024.09.13.612926.. (PMID: 39314292)
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Grant Information: R21 EY020631 United States EY NEI NIH HHS; R01 NS113078 United States NS NINDS NIH HHS; P30 EY019007 United States EY NEI NIH HHS; R24 EY015634 United States EY NEI NIH HHS; R01 MH129031 United States MH NIMH NIH HHS; R01 EY032938 United States EY NEI NIH HHS; R01 EY017039 United States EY NEI NIH HHS
Contributed Indexing: Keywords: Purkinje cells; cerebellum; reinforcement learning; visuomotor association task
Entry Date(s): Date Created: 20260831 Date Completed: 20261007 Latest Revision: 20261011
Update Code: 20261011
PubMed Central ID: PMC13649629
DOI: 10.1523/JNEUROSCI.0082-25.2026
PMID: 42674976
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.0082-25.2026