[Optimal measurement time for evaluating gallbladder contraction function by oral protein bar combined with olive oil: a prospective, multicenter, single-blind, crossover trial].

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	[Optimal measurement time for evaluating gallbladder contraction function by oral protein bar combined with olive oil: a prospective, multicenter, single-blind, crossover trial].
Συγγραφείς:	Deng L; Department of Ultrasonic Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, China First Clinical Medical College of Lanzhou University, Lanzhou 730000, China., Xin H; Department of Ultrasonography, Liaoning Jinqiu Hospital, Shenyang 110016, China., Wu D; Department of Ultrasonography, First Hospital of Qinhuangdao, Qinhuangdao 066000, China., Zhang BD; First Clinical Medical College of Lanzhou University, Lanzhou 730000, China., Xu H; Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China Department of Cardiology, Gansu Province Central Hospital, Lanzhou 730000, China., Sun YY; Ultrasonic Medicine Center, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710054, China., Lin YY; Department of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, China., Yue P; Department of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, China., Yuan JQ; Clinical Research Center, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, China., Meng WB; Department of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, China.
Πηγή:	Zhonghua wai ke za zhi [Chinese journal of surgery] [Zhonghua Wai Ke Za Zhi] 2026 Oct 01; Vol. 64 (10), pp. 1090-1097.
Τύπος έκδοσης:	Journal Article; Randomized Controlled Trial; Multicenter Study; English Abstract
Γλώσσα:	Chinese
Στοιχεία περιοδικού:	Publisher: Zhonghua yi xue hui, Wai ke xue hui Country of Publication: China NLM ID: 0153611 Publication Model: Print Cited Medium: Print ISSN: 0529-5815 (Print) Linking ISSN: 05295815 NLM ISO Abbreviation: Zhonghua Wai Ke Za Zhi Subsets: MEDLINE
Imprint Name(s):	Original Publication: Beijing : Zhonghua yi xue hui, Wai ke xue hui
Ιατρικοί όροι (MeSH):	Gallbladder/physiology , Gallbladder/diagnostic imaging , Plant Oils* , Gallbladder Emptying* , Muscle Contraction*, Humans ; Single-Blind Method ; Female ; Male ; Adult ; Prospective Studies ; Cross-Over Studies ; Olive Oil ; Young Adult ; Middle Aged
Περίληψη:	Objectives: To explore the optimal time window for evaluating gallbladder contraction function by oral standardized protein bar combined with olive oil, and to verify the measurement stability of this novel method compared with the traditional fried egg test. Methods: This is a prospective, multicenter, single-blind, randomized crossover controlled trial. A total of 112 healthy volunteers from 4 centers (the First Hospital of Lanzhou University, the First Hospital of Qinhuangdao, the Liaoning Jinqiu Hospital, and the Honghui Hospital Affiliated to Xi'an Jiaotong University) were enrolled, with a 1-week washout period between two intervention cycles. Group A received oral fried egg intervention in the first cycle and oral standardized protein bar plus 50 ml extra virgin olive oil in the second cycle; while group B received the interventions in reverse order. Gallbladder ultrasound was performed at fasting state and 30, 50, 70, 90 and 110 min after intervention to measure the long diameter, wide diameter and anteroposterior diameter of the gallbladder, and calculate the gallbladder volume and gallbladder contraction rate. The changing trends of gallbladder contraction rate at each time point were compared between the two interventions, the coefficient of variation (CV) was used to evaluate the measurement stability of the two methods, and paired t-test, repeated measures analysis of variance, and Feltz-Miller asymptotic test were used for statistical analysis. Results: Among the 112 subjects, 47 were male and 65 were female, with an age of (30.6±7.1) years(range:19 to 62 years) and a fasting gallbladder volume of (20.0±7.1) ml. Under both interventions, the gallbladder contraction rate of the subjects began to increase at 30 min after intervention, reached the peak at 50 to 70 min, and then gradually decreased. There was no significant difference in the level of gallbladder contraction rate between the two groups at the peak time point (t=0.421,P=0.674). The intragroup CV of gallbladder contraction rate at each time point in the oral protein bar plus olive oil group was significantly lower than that in the fried egg group (all P<0.05), indicating better measurement stability. No serious adverse events such as acute pancreatitis and gastrointestinal bleeding occurred in either group, and the incidence of mild gastrointestinal adverse events showed no significant difference between the two groups (χ²=0.269, P=0.604). Conclusions: The optimal measurement time window for evaluating gallbladder contraction function with oral protein bar combined with olive oil is 50-70 min after intervention. This method is easy to operate with favorable safety, and its measurement stability is significantly better than the traditional fried egg test, providing a new method option for standardized clinical evaluation of gallbladder contraction function.
Competing Interests:	所有作者声明不存在利益冲突
Grant Information:	25ZDWA009 Major Science and Technology Special Project of Gansu Provincial Science and Technology Plan
Contributed Indexing:	Local Abstract: [Publisher, Chinese] 目的：探讨口服蛋白棒联合橄榄油评估胆囊收缩功能的最佳测量时间窗，并验证该新型方法相较于传统煎蛋法的测量稳定性。方法：本研究为前瞻性、多中心、单盲、随机交叉对照试验研究。纳入来自兰州大学第一医院、秦皇岛市第一医院、辽宁省金秋医院、西安交通大学附属红会医院共4家中心112名健康志愿者作为受试者，实施两周期交叉干预，洗脱期为1周。A组第1周期予口服2枚煎蛋干预，第2周期予口服标准化蛋白棒联合50 ml橄榄油干预；B组干预顺序与A组相反。分别于空腹状态及干预后30、50、70、90、110 min行胆囊超声检查，测量胆囊长径、宽径、前后径，计算胆囊体积及胆囊收缩率，对比两种干预方式下各时间点胆囊收缩率的变化趋势，采用变异系数（CV）评估两种方法的测量稳定性，评估两种方法的测量稳定性，采用配对t检验、重复测量方差分析、Feltz-Miller 渐近检验进行统计学分析。结果： 112名受试者中男性47名、女性65名，年龄（30.6±7.1）岁（范围：19~62岁），空腹胆囊体积（20.0±7.1）ml。两种干预方式下，受试者胆囊收缩率均于干预后30 min开始升高，50~70 min达到峰值，随后逐渐下降；峰值时间点两组胆囊收缩率的差异无统计学意义（t=0.421，P=0.674）。口服蛋白棒联合橄榄油组在各时间点胆囊收缩率的组内CV均低于口服煎蛋组，差异均有统计学意义（P值均<0.05）。试验期间两组均未发生急性胰腺炎、消化道出血等严重不良事件，轻微胃肠道不良事件发生率差异无统计学意义（χ²=0.269，P=0.604）。结论：口服蛋白棒联合橄榄油评估胆囊收缩功能的最佳测量时间窗为干预后50~70 min，该方法操作简便、安全性好，测量稳定性优于传统煎蛋法，可为临床胆囊收缩功能的标准化评估提供新选择。.
Substance Nomenclature:	0 (Olive Oil) 0 (Plant Oils)
Entry Date(s):	Date Created: 20260830 Date Completed: 20261010 Latest Revision: 20261015
Update Code:	20261015
DOI:	10.3760/cma.j.cn112139-20260616-00264
PMID:	42669445
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	0529-5815
DOI:	10.3760/cma.j.cn112139-20260616-00264