Academic Journal
Single-molecule thermodynamics of rotary molecular motors in oxidative phosphorylation: Application to physical transport processes.
| Τίτλος: | Single-molecule thermodynamics of rotary molecular motors in oxidative phosphorylation: Application to physical transport processes. |
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| Συγγραφείς: | Nath S; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. Electronic address: sunath@iitd.ac.in. |
| Πηγή: | Bio Systems [Biosystems] 2026 Oct; Vol. 268, pp. 105934. Date of Electronic Publication: 2026 Aug 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0430773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8324 (Electronic) Linking ISSN: 03032647 NLM ISO Abbreviation: Biosystems Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Science Ireland Original Publication: Amsterdam, North-Holland Pub. Co. |
| Ιατρικοί όροι (MeSH): | Molecular Motor Proteins*/metabolism , Molecular Motor Proteins*/chemistry , Proton-Translocating ATPases*/metabolism , Proton-Translocating ATPases*/chemistry , Oxidative Phosphorylation* , Thermodynamics*, Adenosine Triphosphate/metabolism ; Biological Transport/physiology |
| Περίληψη: | Classical thermodynamics has been enormously successful in quantitatively describing macroscopic processes by using its standard, well-known ensemble approach to analyze systems. Yet today, we know from a number of modern developments in physical chemistry, biochemistry, biophysics, and structural and molecular biology that several biochemical processes in enzymes, molecular motors, and other small systems take place in a single-molecule mode, one molecule/ion at a time. How can such single-molecule processes be described and reconciled using thermodynamics within a classical framework? The reader is brought up to date on recent attempts to answer this question (Section 1). The issues and challenges are addressed afresh by a modification of Gibbs' classical theory of irreversible processes, adapted to single molecules. After discussing the assumptions of the Gibbs framework and equation (Section 2), it is applied to local quantities, and a single molecule thermodynamics of physical processes is developed (Section 3). It is shown, by quantitative calculations, how to apply the results of the theory to membrane transport at a molecular level and to the prototype rotary molecular motor, F (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Biological energy transduction; Biological thermodynamics or biothermodynamics; F(O)F(1)-ATP synthase and ATP synthesis/hydrolysis; Intramembrane binding sites; Ion transport across membranes; Irreversible thermodynamics and nonequilibrium thermodynamics; Local fields; Mitchell's chemiosmotic theory; Molecular motors and nanosystems; Molecular theory; Nath's two-ion theory of energy coupling and ATP synthesis; Non-ergodic processes; Oxidative phosphorylation and photophosphorylation; Proton and anion in condensed media; Single molecules; Succinate |
| Substance Nomenclature: | 8L70Q75FXE (Adenosine Triphosphate) 0 (Molecular Motor Proteins) EC 3.6.3.14 (Proton-Translocating ATPases) |
| Entry Date(s): | Date Created: 20260828 Date Completed: 20260906 Latest Revision: 20260914 |
| Update Code: | 20260914 |
| DOI: | 10.1016/j.biosystems.2026.105934 |
| PMID: | 42665224 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-8324 |
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| DOI: | 10.1016/j.biosystems.2026.105934 |