Academic Journal
Bridging the Gap: Translating Microemboli-Induced Spreading Depolarization Into Clinical Practice.
| Τίτλος: | Bridging the Gap: Translating Microemboli-Induced Spreading Depolarization Into Clinical Practice. |
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| Συγγραφείς: | Brammer Kreiberg MP; Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Denmark., Hamann S; Department of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Denmark.; Department of Clinical Medicine, University of Copenhagen, Denmark.; Rothschild Foundation Hospital, Paris, France., Rosenbaum S; Department of Neurology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark., Rossing K; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Denmark., Gall MA; Medical & Translational Science, Diabetes, Cardiovascular, Liver & Rare Disease, Novo Nordisk A/S, Soeborg, Denmark; and., Ayata C; Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown., Hougaard A; Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Denmark.; Department of Clinical Medicine, University of Copenhagen, Denmark. |
| Πηγή: | Neurology [Neurology] 2026 Oct 13; Vol. 107 (7), pp. e218484. Date of Electronic Publication: 2026 Aug 28. |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Minneapolis. |
| Ιατρικοί όροι (MeSH): | Intracranial Embolism*/complications , Intracranial Embolism*/physiopathology , Intracranial Embolism*/diagnostic imaging , Cortical Spreading Depression*/physiology , Migraine with Aura*/etiology , Migraine with Aura*/physiopathology , Migraine with Aura*/diagnostic imaging, Humans ; Female ; Aged ; Ultrasonography, Doppler, Transcranial |
| Περίληψη: | A 68-year-old woman developed daily episodes of migraine aura following mitral valve surgery. During aura symptoms, microemboli in the posterior circulation were detected in real time by transcranial Doppler. After initiation of antiplatelet therapy, the daily clinical episodes ceased, and microemboli were not detectable on repeated transcranial Doppler. Spreading depolarization, the underlying mechanism of migraine aura symptoms, is a conserved electrophysiologic phenomenon characterized by a propagating wave of neuronal and glial depolarization. Experimental models demonstrate that spreading depolarization can be triggered by cortical ischemic lesions and by air emboli, cholesterol crystals, or microspheres in the cerebral circulation without apparent tissue injury. This case illustrates cerebral microembolism-triggered clinical episodes suggestive of cortical spreading depolarization. We therefore suggest that transient neurologic episodes with the characteristics of cortical spreading depolarization, that is, sequential, retinotopically or somatotopically spreading, neurologic symptoms with positive features, can be induced by microembolism in humans. |
| Entry Date(s): | Date Created: 20260828 Date Completed: 20260828 Latest Revision: 20260828 |
| Update Code: | 20260829 |
| DOI: | 10.1212/WNL.0000000000218484 |
| PMID: | 42664477 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1526-632X |
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| DOI: | 10.1212/WNL.0000000000218484 |