Academic Journal
Neonatal Interfacility Transport to Tertiary and Quaternary Centres: Clinical Outcomes and System-Level Determinants-A Systematic Review.
| Τίτλος: | Neonatal Interfacility Transport to Tertiary and Quaternary Centres: Clinical Outcomes and System-Level Determinants-A Systematic Review. |
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| Συγγραφείς: | Damian RO; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Boldeanu L; Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Cucu MG; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania., Siminel MA; Department of Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Butoi MA; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Belghiru VI; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Nica S; Department of Emergency and First Aid, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.; University Emergency Hospital of Bucharest, 050098 Bucharest, Romania., Pădureanu V; Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Assani MZ; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Immunology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Rădulescu VM; Department of Medical Informatics and Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Geormaneanu C; Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Boldeanu MV; Department of Immunology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Rotaru LT; Department of Emergency Medicine and First Aid, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. |
| Πηγή: | Children (Basel, Switzerland) [Children (Basel)] 2026 Aug 10; Vol. 13 (8). Date of Electronic Publication: 2026 Aug 10. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101648936 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9067 (Print) Linking ISSN: 22279067 NLM ISO Abbreviation: Children (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2014]- |
| Περίληψη: | Background/Objectives: Outborn neonates-those born outside tertiary perinatal centres and transferred postnatally-may experience higher mortality and morbidity than inborn infants. This systematic review without meta-analysis synthesised contemporary evidence on neonatal interfacility transfer to tertiary and quaternary neonatal centres, focusing on mortality, major morbidity, physiological instability, prognostic tools, and organisational determinants. Methods: Four electronic databases (PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library) were searched for English-language publications from January 2010 to December 2025. Study selection and data extraction were performed independently by two reviewers, with disagreements resolved by consensus. Narrative synthesis followed PRISMA 2020 and SWiM principles. Of the 2456 records identified, 44 publications were retained: 31 primary studies and 13 contextual or methodological sources. Results: Across the primary evidence, outborn status was generally associated with higher mortality and major morbidity, particularly among very preterm infants, although effect magnitude varied across healthcare systems. Hypothermia, respiratory deterioration, and haemodynamic instability were recurrent transport-related complications. Specialised teams, standardised stabilisation, and thermal-management bundles were associated with better physiological stability. TRIPS and TRIPS-II showed prognostic utility. Conclusions: Predominantly observational evidence suggests that neonatal transport outcomes reflect interactions between biological vulnerability, transport-related stress, and system organisation. Strengthening regionalised transport pathways and standardising stabilisation practices may improve outcomes, but causal inference remains limited. |
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| Contributed Indexing: | Keywords: TRIPS score; hypothermia; interfacility transfer; neonatal morbidity; neonatal mortality; neonatal transport; neurodevelopmental outcomes; outborn infants; premature infants; quaternary neonatal care; regionalised perinatal care; tertiary neonatal care; transport-associated adverse events |
| Entry Date(s): | Date Created: 20260827 Date Completed: 20260827 Latest Revision: 20260829 |
| Update Code: | 20260829 |
| PubMed Central ID: | PMC13511184 |
| DOI: | 10.3390/children13081064 |
| PMID: | 42650402 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2227-9067 |
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| DOI: | 10.3390/children13081064 |