Academic Journal
In silico framework for benchmarking optogenetic hearing restoration.
| Τίτλος: | In silico framework for benchmarking optogenetic hearing restoration. |
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| Συγγραφείς: | Khurana L; University Medical Center Göttingen, Institute for Auditory Neuroscience, Göttingen, Germany.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Auditory Neuroscience & Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Junior Research Group 'Computational Neuroscience and Neuroengineering', Göttingen, Germany.; University of Göttingen, The doctoral program 'Sensory and Motor Neuroscience', Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB), Göttingen, Germany., Nejedly P; University Medical Center Göttingen, Institute for Auditory Neuroscience, Göttingen, Germany.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; University of Göttingen, International Max Planck Research School for Neurosciences (IMPRS), Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB), Göttingen, Germany., Zhang Y; Hannover Medical School (MHH), Hannover, Germany.; Cluster of Excellence 'Hearing4All', Hannover, Germany., Jagger DJ; Centre for Auditory Research, UCL Ear Institute, University College London, London, United Kingdom., Nogueira W; Hannover Medical School (MHH), Hannover, Germany.; Cluster of Excellence 'Hearing4All', Hannover, Germany.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.; Department of Microelectronics and Electronic Systems, Institute of Neuroscience, Universitat Autonoma de Barcelona, Spain., Moser T; University Medical Center Göttingen, Institute for Auditory Neuroscience, Göttingen, Germany.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Auditory Neuroscience & Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; University Medical Center Göttingen, InnerEarLab, Göttingen, Germany.; University of Göttingen, Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), Göttingen, Germany.; University of Göttingen, Collaborative Research Center 1690 (CRC1690), Göttingen, Germany.; University Medical Center Göttingen, Else Kröner Fresenius Center for Optogenetic Therapies, 37075 Göttingen, Germany., Jablonski L; University Medical Center Göttingen, Institute for Auditory Neuroscience, Göttingen, Germany.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Junior Research Group 'Computational Neuroscience and Neuroengineering', Göttingen, Germany.; University Medical Center Göttingen, InnerEarLab, Göttingen, Germany.; University Medical Center Göttingen, Else Kröner Fresenius Center for Optogenetic Therapies, 37075 Göttingen, Germany. |
| Πηγή: | Journal of neural engineering [J Neural Eng] 2026 Sep 24; Vol. 23 (5). Date of Electronic Publication: 2026 Sep 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101217933 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-2552 (Electronic) Linking ISSN: 17412552 NLM ISO Abbreviation: J Neural Eng Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol, U.K. : Institute of Physics Pub., 2004- |
| Ιατρικοί όροι (MeSH): | Optogenetics*/methods , Optogenetics*/standards , Cochlear Implants*/standards , Benchmarking*/methods , Benchmarking*/standards , Computer Simulation*, Spiral Ganglion/physiology ; Electric Stimulation/methods ; Cochlea/physiology ; Humans |
| Περίληψη: | Objective. Cochlear implants (CI) partially restore hearing in profoundly hearing-impaired or deaf individuals by electrically stimulating the auditory nerve. A primary bottleneck in electrical CIs is the broad spread of electrical current from each electrode that limits the transfer of spectral information, which might be overcome by future spatially confined optogenetic stimulation. Here we established an in silico framework, FraSCO, to model sound encoding in the human cochlea by an optical CI (oCI) for testing the potential of optogenetic hearing restoration.Approach. The biophysical modelling framework combined an optical ray tracing model implementing a human cochlea implanted with a waveguide-based oCI with a single compartment model of optogenetically modified spiral ganglion neurons (SGNs). The input was an optogenetic sound coding strategy and the quality of the neural representation was evaluated based on comparison of neurograms evoked by optogenetic and electrical stimulation to the spectrogram of the sound applied. The model incorporated technologically feasible properties of the oCIs with 64 stimulation channels.Main results. The biophysical modelling framework successfully captured essential physiological features of optogenetic SGN stimulation with a minimal set of ion channel types expressed in the SGN soma. Working with a sample of 1000 SGNs distributed along the tonotopic axis to represent sound encoding, we found that improved spectral selectivity achieves comparable information encoding to electrical implants despite lower stimulation rates in current implementations of optogenetic stimulation. We also found that potential oCI users are predicted to be less impacted by noisy backgrounds.Significance. The established computational framework enables an in silico investigation and benchmarking of sound encoding in the cochlea by future oCI and state-of-the-art electrical CI. The results of the exemplary application indicate that optogenetic sound encoding has potential to improve speech understanding in noisy environments for CI users. (Creative Commons Attribution license.) |
| Contributed Indexing: | Keywords: cochlear implants; framework; hearing; models; optogenetics; stimulation |
| Entry Date(s): | Date Created: 20260826 Date Completed: 20260924 Latest Revision: 20260924 |
| Update Code: | 20260925 |
| DOI: | 10.1088/1741-2552/ae9eec |
| PMID: | 42648323 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1741-2552 |
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| DOI: | 10.1088/1741-2552/ae9eec |