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Emerging insights into the physical health burden of personality disorders.

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Title: Emerging insights into the physical health burden of personality disorders.
Authors: Šimunović Filipčić I; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science., Filipčić I; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science.; Psychiatric Clinic Sveti Ivan, Zagreb, Croatia., Jurčić Čulina I; University of Applied Health Science., Marčinko D; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb., Jakšić N; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.
Source: Current opinion in psychiatry [Curr Opin Psychiatry] 2026 Sep 01; Vol. 39 (5), pp. 357-363. Date of Electronic Publication: 2026 Jul 30.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6578 (Electronic) Linking ISSN: 09517367 NLM ISO Abbreviation: Curr Opin Psychiatry Subsets: MEDLINE
Imprint Name(s): Publication: : Philadelphia Pa : Lippincott Williams & Wilkins
Original Publication: Philadelphia, PA, USA : Gower Academic Journals, c1988-
MeSH Terms: Personality Disorders*/epidemiology , Cost of Illness* , Health Status*, Chronic Disease/epidemiology ; Borderline Personality Disorder/epidemiology ; Humans ; Comorbidity ; Multimorbidity ; Mortality, Premature
Abstract: Purpose of Review: This review summarizes recent evidence on the physical health burden associated with personality disorders (PDs), focusing on physical comorbidity and multimorbidity, physical symptoms, and premature mortality.
Recent Findings: Accumulating evidence indicates that individuals with PDs experience markedly elevated rates of chronic physical illness, multimorbidity, and premature mortality. Large-scale cohort studies demonstrate increased risks of cardiovascular disease, myocardial infarction, stroke, and all-cause mortality emerging early in life. Recent investigations further show that nearly half of individuals with PDs meet criteria for chronic physical multimorbidity. Borderline personality disorder (BPD) appears especially associated with broad somatic burden, including pain-related conditions, accompanied by substantially reduced life expectancy. Dimensional approaches additionally suggest that PD severity and maladaptive domains, particularly Negative Affectivity, are independently linked to greater somatic burden. Current evidence supports multifactorial mechanisms involving maladaptive health behaviors, chronic stress-system dysregulation, systemic inflammation, metabolic changes, and healthcare disparities.
Summary: PDs are associated with a substantial yet underrecognized physical health burden. Converging evidence supports a systemic model in which personality pathology contributes to increased somatic (multi)morbidity and premature mortality through interacting behavioral, biological, developmental, and healthcare-related mechanisms. Integrating physical and mental healthcare may help reduce excess morbidity and mortality in this population.
(Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.)
References: Dixon-Gordon KL, Conkey LC, Whalen DJ. Recent advances in understanding physical health problems in personality disorders. Curr Opin Psychol 2018; 21:1–5.
Leichsenring F, Fonagy P, Heim N, et al. Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies. World Psychiatry 2024; 23:4–25.
Quirk SE, Berk M, Chanen AM, et al. Population prevalence of personality disorder and associations with physical health comorbidities and healthcare service utilization: a review. Personal Disord 2016; 7:136–146.
Šimunović Filipčić I, Jakšić N, Levaj S, et al. Physical multimorbidity in psychiatric patients with personality disorders: Insights within the ICD-11 framework. Gen Hosp Psychiatry 2024; 89:16–22.
Halstead S, Sartorius N, Every-Palmer S, et al. Physical multimorbidity and mental illness: a global challenge. Aust N Z J Psychiatry 2024; 58:293–296.
Filipčić I, Šimunović Filipčić I, Grošić V, et al. Patterns of chronic physical multimorbidity in psychiatric and general population. J Psychosom Res 2018; 114:72–80.
Kjær JN, Biskin R, Vestergaard C, Munk-Jørgensen P. All-cause mortality of hospital-treated borderline personality disorder: a nationwide cohort study. J Personal Disord 2020; 34:723–735.
Temes CM, Frankenburg FR, Fitzmaurice GM, Zanarini MC. Deaths by suicide and other causes among patients with borderline personality disorder and personality-disordered comparison subjects over 24 years of prospective follow-up. J Clin Psychiatry 2019; 80:18m12436.
Björkenstam E, Björkenstam C, Holm H, et al. Excess cause-specific mortality in in-patient-treated individuals with personality disorder: 25-year nationwide population-based study. Br J Psychiatry 2015; 207:339–345.
Fok MLY, Hayes RD, Chang CK, et al. Life expectancy at birth and all-cause mortality among people with personality disorder. J Psychosom Res 2012; 73:104–107.
Høye A, Jacobsen BK, Bramness JG, et al. Total and cause-specific mortality in patients with personality disorders: the association between comorbid severe mental illness and substance use disorders. Soc Psychiatry Psychiatr Epidemiol 2021; 56:1809–1819.
Shadid J, Ferrari AJ, Bach B, et al. The global epidemiology of personality disorder: a systematic review and meta-regression. Lancet Psychiatry 2025; 12:932–946.
El-Gabalawy R, Katz LY, Sareen J. Comorbidity and associated severity of borderline personality disorder and physical health conditions in a nationally representative sample. Psychosom Med 2010; 72:641–647.
Hastrup LH, Jennum P, Ibsen R, et al. Borderline personality disorder and the diagnostic co-occurrence of mental health disorders and somatic diseases: a controlled prospective national register-based study. Acta Psychiatr Scand 2024; 149:124–132.
Schneider F, Erhart M, Hewer W, et al. Mortality and medical comorbidity in the severely mentally ill. Dtsch Arzteblatt Int 2019; 116 (23–24):405–411.
Tate AE, Sahlin H, Liu S, et al. Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors. Mol Psychiatry 2022; 27:2514–2521.
Powers AD, Oltmanns TF. Borderline personality pathology and chronic health problems in later adulthood: the mediating role of obesity. Personal Disord 2013; 4:152–159.
Moran P, Stewart R, Brugha T, et al. Personality disorder and cardiovascular disease: results from a national household survey. J Clin Psychiatry 2007; 68:69–74.
Gerlach G, Loeber S, Herpertz S. Personality disorders and obesity: a systematic review. Obes Rev 2016; 17:691–723.
Fok M, Hotopf M, Stewart R, et al. Personality disorder and self-rated health: a population-based cross-sectional survey. J Personal Disord 2014; 28:319–333.
Halstead S, Siskind D, Warren N. Making meaning of multimorbidity and severe mental illness: a viewpoint. Aust N Z J Psychiatry 2024; 58:12–20.
Fok ML-Y, Chang C-K, Broadbent M, et al. General hospital admission rates in people diagnosed with personality disorder. Acta Psychiatr Scand. 2019;139:248–55.
Sansone RA, Sansone LA. Borderline personality disorder in the medical setting: suggestive behaviors, syndromes, and diagnoses. Innov Clin Neurosci 2015; 12 (7–8):39–44.
Schmaling KB, Fales JL. The association between borderline personality disorder and somatoform disorders: a systematic review and meta-analysis. Clin Psychol Sci Pract 2018; 25:e12244.
Lamm TT, Von Schrottenberg V, Rauch A, et al. Five-factor personality traits and functional somatic disorder: a systematic review and meta-analysis. Clin Psychol Rev 2025; 115:102529.
Toussaint A, Weigel A, Löwe B, et al. The overlooked burden of persistent physical symptoms: a call for action in European healthcare. Lancet Reg Health Eur 2025; 48:101140.
Marčinko D, Jakšić N. Šimunović Filipčić I, Mustač F. Contemporary psychological perspectives of personality disorders. Curr Opin Psychiatry 2021; 34:497–502.
Bozzatello P, Marin G, Gabriele G, et al. Metabolic dysfunctions, dysregulation of the autonomic nervous system, and echocardiographic parameters in borderline personality disorder: a narrative review. Int J Mol Sci 2024; 25:12286.
Fitzpatrick S, Dixon-Gordon KL, Turner CJ, et al. Emotion dysregulation in personality disorders. Curr Psychiatry Rep 2023; 25:223–231.
Kramer U, De Panfilis C, Barkauskiene R, et al. Psychosocial functioning in personality disorders. Borderline Person Disord Emot Dysregul 2025; 12:46.
Tiosano S, Laur L, Tirosh A, et al. Personality disorders and cause-specific mortality: a nationwide study of 2 million adolescents. Psychol Med 2022; 52:1746–1754.
Park CS, Choi EK, Han KD, et al. Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study. Eur J Prev Cardiol 2023; 30:1582–1592.
Morreale M, Holingue C, Samuels J, Nestadt G. Long-term physical health outcomes of obsessive-compulsive personality disorder traits. J Clin Psychol 2021; 77:2626–2637.
Kampling H, Riedl D, Lampe A, et al. Somatic symptom disorder and the role of epistemic trust, personality functioning and child abuse: results from a population-based representative German sample. J Affect Disord 2025; 373:429–437.
Von Schrottenberg V, Kerber A, Sterner P, et al. Exploring associations of somatic symptom disorder with personality dysfunction and specific maladaptive traits. Psychopathology 2024; 58:1–12.
Adam LC, Halmschlager N, Zimmermann J, et al. Associations between maladaptive personality traits and physical health: results of a cohort study with a large representative sample. J Psychosom Res 2026; 204:112584.
Leichsenring F, Heim N, Leweke F, et al. Borderline personality disorder: a review. JAMA 2023; 329:670.
Chan JKN, Li RCY, Wong CSM, et al. Association of borderline personality disorder with physical diseases and mortality: a 16-year population-based electronic health-record cohort study in Hong Kong. Psychother Psychosom 2026; 1–18. doi:10.1159/000551534. (PMID: 10.1159/000551534)
Barber TA, Ringwald WR, Wright AGC, Manuck SB. Borderline personality disorder traits associate with midlife cardiometabolic risk. Personal Disord 2020; 11:151–156.
Nance M, Stetsiv K, McNamara IA, et al. Acute, chronic, and everyday physical pain in borderline personality disorder. Curr Psychiatry Rep 2024; 26:240–248.
Álvarez-Tomás I, Soler J, Schmidt C, Pascual JC. Physical health, primary care utilization and long-term quality of life in borderline personality disorder: a 10-year follow-up study in a Spanish sample. J Psychosom Res 2024; 179:111623.
Streit F, Awasthi S, Hall AS, et al. Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders. MedRxiv Prepr Serv Health Sci. 2025;2024.11.12.24316957. doi:10.1101/2024.11.12.24316957.
Frankenburg FR, Zanarini MC. The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of healthcare utilization. J Clin Psychiatry 2004; 65:1660–1665.
Simon J, Lambrecht B, Bach B. Cross-walking personality disorder types to ICD-11 trait domains: an overview of current findings. Front Psychiatry 2023; 14:1175425.
Fiorillo A, Firth J, Misiak B, et al. From lifestyle psychiatry to whole person health: Evidence, dissemination, and scalable approaches. Eur Psychiatry J Assoc Eur Psychiatr 2025; 69:e15.
Navarre KM. “You sure she's not making this up?”: a qualitative investigation of stigma toward adults with borderline personality disorder in physical healthcare settings. Personal Ment Health 2025; 19:e1646.
Firth J, Siddiqi N, Koyanagi A, et al. The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. Lancet Psychiatry 2019; 6:675–712.
Dokucu ME, Cloninger CR. Personality disorders and physical comorbidities: a complex relationship. Curr Opin Psychiatry 2019; 32:435–441.
Jakšić N, Šimunović Filipčić I, Šagud M, et al. Childhood traumatic experiences and ICD-11 model of personality disorders: a study among Croatian psychiatric patients. Psychiatr Q 2026; doi:10.1007/s11126-026-10279-2. (PMID: 10.1007/s11126-026-10279-2)
Bozzatello P, Rocca P, Baldassarri L, et al. The role of trauma in early onset borderline personality disorder: a biopsychosocial perspective. Front Psychiatry 2021; 12:721361.
Zakiei A, Khazaie H, Komasi S. The role of the DSM-5 maladaptive personality traits in adherence to sleep hygiene behaviors and sleep duration. Sci Rep 2025; 15:16196.
Contributed Indexing: Keywords: borderline personality disorder; mortality; personality disorders; physical health; somatic comorbidity
Entry Date(s): Date Created: 20260826 Date Completed: 20260826 Latest Revision: 20260826
Update Code: 20260826
DOI: 10.1097/YCO.0000000000001110
PMID: 42644450
Database: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Šimunović+Filipčić+I%22">Šimunović Filipčić I</searchLink>; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science.<br /><searchLink fieldCode="AU" term="%22Filipčić+I%22">Filipčić I</searchLink>; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science.; Psychiatric Clinic Sveti Ivan, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Jurčić+Čulina+I%22">Jurčić Čulina I</searchLink>; University of Applied Health Science.<br /><searchLink fieldCode="AU" term="%22Marčinko+D%22">Marčinko D</searchLink>; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb.<br /><searchLink fieldCode="AU" term="%22Jakšić+N%22">Jakšić N</searchLink>; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.
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  Data: <searchLink fieldCode="JN" term="%228809880%22">Current opinion in psychiatry</searchLink> [Curr Opin Psychiatry] 2026 Sep 01; Vol. 39 (5), pp. 357-363. <i>Date of Electronic Publication: </i>2026 Jul 30.
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  Data: <i>Publication</i>: <Nov. 2011- > : Philadelphia Pa : Lippincott Williams & Wilkins<br /><i>Original Publication</i>: Philadelphia, PA, USA : Gower Academic Journals, c1988-
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose of Review: This review summarizes recent evidence on the physical health burden associated with personality disorders (PDs), focusing on physical comorbidity and multimorbidity, physical symptoms, and premature mortality.<br />Recent Findings: Accumulating evidence indicates that individuals with PDs experience markedly elevated rates of chronic physical illness, multimorbidity, and premature mortality. Large-scale cohort studies demonstrate increased risks of cardiovascular disease, myocardial infarction, stroke, and all-cause mortality emerging early in life. Recent investigations further show that nearly half of individuals with PDs meet criteria for chronic physical multimorbidity. Borderline personality disorder (BPD) appears especially associated with broad somatic burden, including pain-related conditions, accompanied by substantially reduced life expectancy. Dimensional approaches additionally suggest that PD severity and maladaptive domains, particularly Negative Affectivity, are independently linked to greater somatic burden. Current evidence supports multifactorial mechanisms involving maladaptive health behaviors, chronic stress-system dysregulation, systemic inflammation, metabolic changes, and healthcare disparities.<br />Summary: PDs are associated with a substantial yet underrecognized physical health burden. Converging evidence supports a systemic model in which personality pathology contributes to increased somatic (multi)morbidity and premature mortality through interacting behavioral, biological, developmental, and healthcare-related mechanisms. Integrating physical and mental healthcare may help reduce excess morbidity and mortality in this population.<br /> (Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Dixon-Gordon KL, Conkey LC, Whalen DJ. Recent advances in understanding physical health problems in personality disorders. Curr Opin Psychol 2018; 21:1–5.<br />Leichsenring F, Fonagy P, Heim N, et al. Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies. World Psychiatry 2024; 23:4–25.<br />Quirk SE, Berk M, Chanen AM, et al. Population prevalence of personality disorder and associations with physical health comorbidities and healthcare service utilization: a review. Personal Disord 2016; 7:136–146.<br />Šimunović Filipčić I, Jakšić N, Levaj S, et al. Physical multimorbidity in psychiatric patients with personality disorders: Insights within the ICD-11 framework. Gen Hosp Psychiatry 2024; 89:16–22.<br />Halstead S, Sartorius N, Every-Palmer S, et al. Physical multimorbidity and mental illness: a global challenge. Aust N Z J Psychiatry 2024; 58:293–296.<br />Filipčić I, Šimunović Filipčić I, Grošić V, et al. Patterns of chronic physical multimorbidity in psychiatric and general population. J Psychosom Res 2018; 114:72–80.<br />Kjær JN, Biskin R, Vestergaard C, Munk-Jørgensen P. All-cause mortality of hospital-treated borderline personality disorder: a nationwide cohort study. J Personal Disord 2020; 34:723–735.<br />Temes CM, Frankenburg FR, Fitzmaurice GM, Zanarini MC. Deaths by suicide and other causes among patients with borderline personality disorder and personality-disordered comparison subjects over 24 years of prospective follow-up. J Clin Psychiatry 2019; 80:18m12436.<br />Björkenstam E, Björkenstam C, Holm H, et al. Excess cause-specific mortality in in-patient-treated individuals with personality disorder: 25-year nationwide population-based study. Br J Psychiatry 2015; 207:339–345.<br />Fok MLY, Hayes RD, Chang CK, et al. Life expectancy at birth and all-cause mortality among people with personality disorder. J Psychosom Res 2012; 73:104–107.<br />Høye A, Jacobsen BK, Bramness JG, et al. Total and cause-specific mortality in patients with personality disorders: the association between comorbid severe mental illness and substance use disorders. Soc Psychiatry Psychiatr Epidemiol 2021; 56:1809–1819.<br />Shadid J, Ferrari AJ, Bach B, et al. The global epidemiology of personality disorder: a systematic review and meta-regression. Lancet Psychiatry 2025; 12:932–946.<br />El-Gabalawy R, Katz LY, Sareen J. Comorbidity and associated severity of borderline personality disorder and physical health conditions in a nationally representative sample. Psychosom Med 2010; 72:641–647.<br />Hastrup LH, Jennum P, Ibsen R, et al. Borderline personality disorder and the diagnostic co-occurrence of mental health disorders and somatic diseases: a controlled prospective national register-based study. Acta Psychiatr Scand 2024; 149:124–132.<br />Schneider F, Erhart M, Hewer W, et al. Mortality and medical comorbidity in the severely mentally ill. Dtsch Arzteblatt Int 2019; 116 (23–24):405–411.<br />Tate AE, Sahlin H, Liu S, et al. Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors. Mol Psychiatry 2022; 27:2514–2521.<br />Powers AD, Oltmanns TF. Borderline personality pathology and chronic health problems in later adulthood: the mediating role of obesity. Personal Disord 2013; 4:152–159.<br />Moran P, Stewart R, Brugha T, et al. Personality disorder and cardiovascular disease: results from a national household survey. J Clin Psychiatry 2007; 68:69–74.<br />Gerlach G, Loeber S, Herpertz S. Personality disorders and obesity: a systematic review. Obes Rev 2016; 17:691–723.<br />Fok M, Hotopf M, Stewart R, et al. Personality disorder and self-rated health: a population-based cross-sectional survey. J Personal Disord 2014; 28:319–333.<br />Halstead S, Siskind D, Warren N. Making meaning of multimorbidity and severe mental illness: a viewpoint. Aust N Z J Psychiatry 2024; 58:12–20.<br />Fok ML-Y, Chang C-K, Broadbent M, et al. General hospital admission rates in people diagnosed with personality disorder. Acta Psychiatr Scand. 2019;139:248–55.<br />Sansone RA, Sansone LA. Borderline personality disorder in the medical setting: suggestive behaviors, syndromes, and diagnoses. Innov Clin Neurosci 2015; 12 (7–8):39–44.<br />Schmaling KB, Fales JL. The association between borderline personality disorder and somatoform disorders: a systematic review and meta-analysis. Clin Psychol Sci Pract 2018; 25:e12244.<br />Lamm TT, Von Schrottenberg V, Rauch A, et al. Five-factor personality traits and functional somatic disorder: a systematic review and meta-analysis. Clin Psychol Rev 2025; 115:102529.<br />Toussaint A, Weigel A, Löwe B, et al. The overlooked burden of persistent physical symptoms: a call for action in European healthcare. Lancet Reg Health Eur 2025; 48:101140.<br />Marčinko D, Jakšić N. Šimunović Filipčić I, Mustač F. Contemporary psychological perspectives of personality disorders. Curr Opin Psychiatry 2021; 34:497–502.<br />Bozzatello P, Marin G, Gabriele G, et al. Metabolic dysfunctions, dysregulation of the autonomic nervous system, and echocardiographic parameters in borderline personality disorder: a narrative review. Int J Mol Sci 2024; 25:12286.<br />Fitzpatrick S, Dixon-Gordon KL, Turner CJ, et al. Emotion dysregulation in personality disorders. Curr Psychiatry Rep 2023; 25:223–231.<br />Kramer U, De Panfilis C, Barkauskiene R, et al. Psychosocial functioning in personality disorders. Borderline Person Disord Emot Dysregul 2025; 12:46.<br />Tiosano S, Laur L, Tirosh A, et al. Personality disorders and cause-specific mortality: a nationwide study of 2 million adolescents. Psychol Med 2022; 52:1746–1754.<br />Park CS, Choi EK, Han KD, et al. Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study. Eur J Prev Cardiol 2023; 30:1582–1592.<br />Morreale M, Holingue C, Samuels J, Nestadt G. Long-term physical health outcomes of obsessive-compulsive personality disorder traits. J Clin Psychol 2021; 77:2626–2637.<br />Kampling H, Riedl D, Lampe A, et al. Somatic symptom disorder and the role of epistemic trust, personality functioning and child abuse: results from a population-based representative German sample. J Affect Disord 2025; 373:429–437.<br />Von Schrottenberg V, Kerber A, Sterner P, et al. Exploring associations of somatic symptom disorder with personality dysfunction and specific maladaptive traits. Psychopathology 2024; 58:1–12.<br />Adam LC, Halmschlager N, Zimmermann J, et al. Associations between maladaptive personality traits and physical health: results of a cohort study with a large representative sample. J Psychosom Res 2026; 204:112584.<br />Leichsenring F, Heim N, Leweke F, et al. Borderline personality disorder: a review. JAMA 2023; 329:670.<br />Chan JKN, Li RCY, Wong CSM, et al. Association of borderline personality disorder with physical diseases and mortality: a 16-year population-based electronic health-record cohort study in Hong Kong. Psychother Psychosom 2026; 1–18. doi:10.1159/000551534. (PMID: <searchLink fieldCode="PM" term="%2210%2E1159%2F000551534%22">10.1159/000551534)</searchLink><br />Barber TA, Ringwald WR, Wright AGC, Manuck SB. Borderline personality disorder traits associate with midlife cardiometabolic risk. Personal Disord 2020; 11:151–156.<br />Nance M, Stetsiv K, McNamara IA, et al. Acute, chronic, and everyday physical pain in borderline personality disorder. Curr Psychiatry Rep 2024; 26:240–248.<br />Álvarez-Tomás I, Soler J, Schmidt C, Pascual JC. Physical health, primary care utilization and long-term quality of life in borderline personality disorder: a 10-year follow-up study in a Spanish sample. J Psychosom Res 2024; 179:111623.<br />Streit F, Awasthi S, Hall AS, et al. Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders. MedRxiv Prepr Serv Health Sci. 2025;2024.11.12.24316957. doi:10.1101/2024.11.12.24316957.<br />Frankenburg FR, Zanarini MC. The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of healthcare utilization. J Clin Psychiatry 2004; 65:1660–1665.<br />Simon J, Lambrecht B, Bach B. Cross-walking personality disorder types to ICD-11 trait domains: an overview of current findings. Front Psychiatry 2023; 14:1175425.<br />Fiorillo A, Firth J, Misiak B, et al. From lifestyle psychiatry to whole person health: Evidence, dissemination, and scalable approaches. Eur Psychiatry J Assoc Eur Psychiatr 2025; 69:e15.<br />Navarre KM. “You sure she's not making this up?”: a qualitative investigation of stigma toward adults with borderline personality disorder in physical healthcare settings. Personal Ment Health 2025; 19:e1646.<br />Firth J, Siddiqi N, Koyanagi A, et al. The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. Lancet Psychiatry 2019; 6:675–712.<br />Dokucu ME, Cloninger CR. Personality disorders and physical comorbidities: a complex relationship. Curr Opin Psychiatry 2019; 32:435–441.<br />Jakšić N, Šimunović Filipčić I, Šagud M, et al. Childhood traumatic experiences and ICD-11 model of personality disorders: a study among Croatian psychiatric patients. Psychiatr Q 2026; doi:10.1007/s11126-026-10279-2. 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  Data: <i>Keywords: </i>borderline personality disorder; mortality; personality disorders; physical health; somatic comorbidity
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  Data: <i>Date Created: </i>20260826 <i>Date Completed: </i>20260826 <i>Latest Revision: </i>20260826
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        Value: 10.1097/YCO.0000000000001110
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        Text: English
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        StartPage: 357
    Subjects:
      – SubjectFull: Chronic Disease epidemiology
        Type: general
      – SubjectFull: Borderline Personality Disorder epidemiology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Comorbidity
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      – SubjectFull: Mortality, Premature
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      – SubjectFull: Personality Disorders epidemiology
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      – SubjectFull: Cost of Illness
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      – SubjectFull: Health Status
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      – TitleFull: Emerging insights into the physical health burden of personality disorders.
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              M: 09
              Text: 2026 Sep 01
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              Y: 2026
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