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Emerging insights into the physical health burden of personality disorders.

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Τίτλος: Emerging insights into the physical health burden of personality disorders.
Συγγραφείς: Šimunović Filipčić I; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science., Filipčić I; School of Medicine, University of Zagreb, Zagreb.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek.; University of Applied Health Science.; Psychiatric Clinic Sveti Ivan, Zagreb, Croatia., Jurčić Čulina I; University of Applied Health Science., Marčinko D; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.; School of Medicine, University of Zagreb, Zagreb., Jakšić N; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb.
Πηγή: Current opinion in psychiatry [Curr Opin Psychiatry] 2026 Sep 01; Vol. 39 (5), pp. 357-363. Date of Electronic Publication: 2026 Jul 30.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6578 (Electronic) Linking ISSN: 09517367 NLM ISO Abbreviation: Curr Opin Psychiatry Subsets: MEDLINE
Imprint Name(s): Publication: : Philadelphia Pa : Lippincott Williams & Wilkins
Original Publication: Philadelphia, PA, USA : Gower Academic Journals, c1988-
Ιατρικοί όροι (MeSH): Personality Disorders*/epidemiology , Cost of Illness* , Health Status*, Chronic Disease/epidemiology ; Borderline Personality Disorder/epidemiology ; Humans ; Comorbidity ; Multimorbidity ; Mortality, Premature
Περίληψη: Purpose of Review: This review summarizes recent evidence on the physical health burden associated with personality disorders (PDs), focusing on physical comorbidity and multimorbidity, physical symptoms, and premature mortality.
Recent Findings: Accumulating evidence indicates that individuals with PDs experience markedly elevated rates of chronic physical illness, multimorbidity, and premature mortality. Large-scale cohort studies demonstrate increased risks of cardiovascular disease, myocardial infarction, stroke, and all-cause mortality emerging early in life. Recent investigations further show that nearly half of individuals with PDs meet criteria for chronic physical multimorbidity. Borderline personality disorder (BPD) appears especially associated with broad somatic burden, including pain-related conditions, accompanied by substantially reduced life expectancy. Dimensional approaches additionally suggest that PD severity and maladaptive domains, particularly Negative Affectivity, are independently linked to greater somatic burden. Current evidence supports multifactorial mechanisms involving maladaptive health behaviors, chronic stress-system dysregulation, systemic inflammation, metabolic changes, and healthcare disparities.
Summary: PDs are associated with a substantial yet underrecognized physical health burden. Converging evidence supports a systemic model in which personality pathology contributes to increased somatic (multi)morbidity and premature mortality through interacting behavioral, biological, developmental, and healthcare-related mechanisms. Integrating physical and mental healthcare may help reduce excess morbidity and mortality in this population.
(Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.)
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Contributed Indexing: Keywords: borderline personality disorder; mortality; personality disorders; physical health; somatic comorbidity
Entry Date(s): Date Created: 20260826 Date Completed: 20260826 Latest Revision: 20260826
Update Code: 20260826
DOI: 10.1097/YCO.0000000000001110
PMID: 42644450
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1473-6578
DOI:10.1097/YCO.0000000000001110