Academic Journal
Neuroimaging correlates of pain in Parkinson's disease: A systematic review of structural and resting-state fMRI studies.
| Τίτλος: | Neuroimaging correlates of pain in Parkinson's disease: A systematic review of structural and resting-state fMRI studies. |
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| Συγγραφείς: | Msigwa SS; Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Kihaga G; Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Yu QY; Department of Epidemiology and Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhu SG; Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, China., Zhu JH; Institute of Nutrition and Diseases and Center for Research, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhang X; Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Wang JY; Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, China. Electronic address: wangjianyong2020@126.com. |
| Πηγή: | The journal of pain [J Pain] 2026 Oct; Vol. 47, pp. 106425. Date of Electronic Publication: 2026 Aug 25. |
| Τύπος έκδοσης: | Journal Article; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : Churchill Livingstone, c2000- |
| Ιατρικοί όροι (MeSH): | Parkinson Disease*/diagnostic imaging , Parkinson Disease*/complications , Parkinson Disease*/physiopathology , Chronic Pain*/diagnostic imaging , Chronic Pain*/etiology , Chronic Pain*/physiopathology , Nerve Net*/diagnostic imaging , Nerve Net*/physiopathology , Magnetic Resonance Imaging* , Neuroimaging* , Connectome*, Humans |
| Περίληψη: | Chronic pain is a common non-motor symptom in Parkinson's disease (PD), but its central neural mechanisms are not fully understood. Structural and resting-state functional MRI offer non-invasive insights into brain structural and functional correlates of pain. This systematic review synthesizes neuroimaging evidence on the neural correlates of pain in PD. A search of PubMed, Scopus, Google Scholar, and Web of Science identified eight case-control studies, including 432 PD patients with pain (PDP), 225 without pain (PDNP), and 257 healthy controls (HCs). Structural MRI revealed prefrontal cortical thinning and reduced insular gyrification, while resting-state functional MRI showed altered activity and connectivity across basal ganglia, limbic, brainstem, sensorimotor, cerebellar, insula-temporo-parietal and parahippocampal networks. Key findings included reduced putamen activity negatively correlated with pain, disrupted striatal-limbic connectivity, and increased raphe nucleus connectivity positively associated with pain. Other alterations included impaired sensorimotor-cerebellar integration and amygdala hypoconnectivity linked to pain severity. Dopamine-responsive and dopamine-unresponsive pain phenotypes displayed distinct connectivity patterns. Compared to HCs, PDP exhibited reduced connectivity in pain-related networks. Dynamic connectivity of default mode and frontoparietal networks showed no consistent links with pain. Two studies employed multimodal imaging approaches. Findings converged with unimodal evidence implicating prefrontal, insular, orbitofrontal, cerebellar, and striato-limbic circuits. White matter abnormalities were observed versus HCs but not consistently between PDP and PDNP. Overall, the findings support a network-based pathophysiological framework for PD-related pain and highlight the need for multimodal, longitudinal, and mechanism- and dopaminergic response-specific investigations to clarify underlying mechanisms and inform targeted therapeutic strategies. REGISTRATION: Registered on the PROSPERO site on November 13, 2025 (ID: CRD420251230685). PERSPECTIVE: This review identifies notable structural and functional alterations in striatal, limbic, brainstem, and sensorimotor-cerebellar networks underlying pain in PD. These findings support a network-based framework for PD-related pain and highlight the need for multimodal, longitudinal, and pain subtype- and treatment response-specific studies to clarify mechanisms and guide targeted interventions. (Copyright © 2026 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest There are no conflicts of interest. |
| Contributed Indexing: | Keywords: Basal ganglia; Chronic pain; Multimodal neuroimaging; Parkinson’s disease |
| Entry Date(s): | Date Created: 20260825 Date Completed: 20260929 Latest Revision: 20261009 |
| Update Code: | 20261009 |
| DOI: | 10.1016/j.jpain.2026.106425 |
| PMID: | 42641775 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1528-8447 |
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| DOI: | 10.1016/j.jpain.2026.106425 |