Academic Journal
S/O/W-based milk mineral-fortified emulsion: a delivery platform offering stability, enhanced bioavailability, and bone health support.
| Τίτλος: | S/O/W-based milk mineral-fortified emulsion: a delivery platform offering stability, enhanced bioavailability, and bone health support. |
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| Συγγραφείς: | Wang X; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China., Tang M; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China., Zhang T; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China., Chen W; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China., Ren S; National Technology Innovation Center for Dairy, Hohhot 010110, China; Inner Mongolia Yili Industrial Group, Co., Ltd, Hohhot 010080, China; Inner Mongolia Dairy Technology Research Institute, Co., Ltd, Hohhot 010110, China., Hou Z; National Technology Innovation Center for Dairy, Hohhot 010110, China; Inner Mongolia Yili Industrial Group, Co., Ltd, Hohhot 010080, China; Inner Mongolia Dairy Technology Research Institute, Co., Ltd, Hohhot 010110, China., Wang C; National Technology Innovation Center for Dairy, Hohhot 010110, China; Inner Mongolia Yili Industrial Group, Co., Ltd, Hohhot 010080, China; Inner Mongolia Dairy Technology Research Institute, Co., Ltd, Hohhot 010110, China., He J; National Technology Innovation Center for Dairy, Hohhot 010110, China; Inner Mongolia Yili Industrial Group, Co., Ltd, Hohhot 010080, China; Inner Mongolia Dairy Technology Research Institute, Co., Ltd, Hohhot 010110, China., Wang Y; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China., Xu D; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China. Electronic address: xuduoxia@th.btbu.edu.cn., Sun B; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China. |
| Πηγή: | Food research international (Ottawa, Ont.) [Food Res Int] 2026 Oct 31; Vol. 242 (Pt 5), pp. 120238. Date of Electronic Publication: 2026 Aug 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| Ιατρικοί όροι (MeSH): | Milk*/chemistry , Minerals*/administration & dosage , Minerals*/chemistry , Minerals*/pharmacokinetics , Bone and Bones*/metabolism , Bone and Bones*/drug effects , Food, Fortified*, Bone Density/drug effects ; Calcium, Dietary/administration & dosage ; Calcium, Dietary/pharmacokinetics ; Animals ; Emulsions ; Female ; Biological Availability ; Rats ; Ovariectomy ; Rats, Sprague-Dawley ; Calcium ; Intestinal Absorption ; Alendronate |
| Περίληψη: | Milk minerals (MMS) are a superior natural calcium source limited by poor dispersibility and stability. Although solid-in-oil-in-water (S/O/W) emulsions improve their stability and in vitro bioaccessibility, their in vivo efficacy remains unconfirmed. This study evaluated the efficacy of S/O/W-based MMS-fortified emulsions (MFEs) in enhancing calcium absorption and bone health using an ovariectomized (OVX) and low-calcium rat model. Over an 8-week period, rats were divided into a sham-operated group and several OVX groups. The OVX rats were randomized into seven subgroups receiving ultrapure water, alendronate (ALN, 1 mg/kg bw), CaCO₃ (Ca2+: 133.3 mg/kg bw), or low and high doses (Ca2+: 66.65 and 133.3 mg/kg bw, respectively) of MMS or MFEs. Compared to the low-dose MMS group (MMS-L), the low-dose MFEs group (MFEs-L) significantly increased calcium absorption by 17.06% and the retention rate by 18.35% (p < 0.05). Furthermore, MFEs-L improved bone mineral density (BMD) by 20.21%, preserved trabecular microarchitecture, enhanced bone biomechanics, and reduced osteoclast numbers. Additionally, MFEs upregulated tight junction proteins (ZO-1 and Occludin) and improved intestinal transit, alleviating the constipation typically caused by traditional calcium supplements. Concurrently, MFEs modulated the gut microbiota composition by enriching beneficial taxa, such as the Bacillota, Bifidobacterium and Lactobacillus, and promoted short-chain fatty acid (SCFA) production. These results indicate that S/O/W-based MFEs represent a promising dietary delivery strategy for MMS, effectively enhancing calcium bioavailability, supporting bone health, and alleviating constipation. (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Alleviate constipation; Bone health; Calcium absorption; S/O/W-based milk minerals (MMS)-fortified emulsion |
| Substance Nomenclature: | 0 (Emulsions) 0 (Minerals) SY7Q814VUP (Calcium) X1J18R4W8P (Alendronate) 0 (Calcium, Dietary) |
| Entry Date(s): | Date Created: 20260824 Date Completed: 20260824 Latest Revision: 20260824 |
| Update Code: | 20260825 |
| DOI: | 10.1016/j.foodres.2026.120238 |
| PMID: | 42637381 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-7145 |
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| DOI: | 10.1016/j.foodres.2026.120238 |