Academic Journal
KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells.
| Τίτλος: | KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells. |
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| Συγγραφείς: | Ni Y; Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Lin Y; Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Wang W; Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Bao Y; Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Chen J; Department of Urology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address: zjdxcj1@126.com. |
| Πηγή: | Urologic oncology [Urol Oncol] 2026 Oct; Vol. 44 (10), pp. 652-661. Date of Electronic Publication: 2026 Aug 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 9805460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2496 (Electronic) Linking ISSN: 10781439 NLM ISO Abbreviation: Urol Oncol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Philadelphia, PA : Elsevier Original Publication: New York, NY : Elsevier Science |
| Ιατρικοί όροι (MeSH): | Histone Demethylases*/metabolism , Histone Demethylases*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/metabolism , Prostatic Neoplasms*/pathology , Epithelial-Mesenchymal Transition*, Male ; Humans ; Cell Proliferation ; Animals ; Cell Line, Tumor ; Mice ; Cell Movement ; Gene Expression Regulation, Neoplastic |
| Περίληψη: | Background and Objective: Prostate cancer is one of the most common male malignancies worldwide. KDM6A, a histone H3K27 demethylase, has been implicated in various cancers; however, its specific functions in prostate cancer remain controversial. This study aimed to investigate the regulatory role of KDM6A in castration-resistant prostate cancer (CRPC). Methods: We analyzed the GEO public database and conducted in vitro and in vivo experiments to examine the function of KDM6A in CRPC. Results: KDM6A expression was downregulated in CRPC compared with primary prostate cancer. KDM6A acted as a tumor suppressor; its depletion promoted proliferation and migration of prostate cancer cells both in vitro and in vivo. Suppression of KDM6A activated epithelial-mesenchymal transition (EMT) via HMGB2, thereby regulating the invasive behavior of prostate cancer. EMT is known to play a critical role in CRPC progression. Conclusions: Our findings reveal the functional role of KDM6A in CRPC and suggest its potential utility in exploring novel therapeutic strategies for CRPC. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Epithelial–mesenchymal transition; HMGB2; KDM6A; Proliferation; Prostate cancer |
| Substance Nomenclature: | EC 1.14.11.- (Histone Demethylases) EC 1.14.11.- (KDM6A protein, human) |
| Entry Date(s): | Date Created: 20260824 Date Completed: 20260918 Latest Revision: 20260918 |
| Update Code: | 20260919 |
| DOI: | 10.1016/j.urolonc.2026.07.029 |
| PMID: | 42636791 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-2496 |
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| DOI: | 10.1016/j.urolonc.2026.07.029 |