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Accelerated organelle movements can indirectly affect the motility of other organelles in plant cells.

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Τίτλος: Accelerated organelle movements can indirectly affect the motility of other organelles in plant cells.
Συγγραφείς: Gu JM; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA., Keith A; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA., Smith K; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA., Nebenführ A; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA.
Πηγή: Journal of cell science [J Cell Sci] 2026 Sep 15; Vol. 139 (18). Date of Electronic Publication: 2026 Sep 25.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
Imprint Name(s): Publication: Cambridge : Company of Biologists
Original Publication: London.
Ιατρικοί όροι (MeSH): Nicotiana*/metabolism , Nicotiana*/cytology , Organelles*/metabolism , Plant Cells*/metabolism, Peroxisomes/metabolism ; Myosins/metabolism ; Actin Cytoskeleton/metabolism ; Microtubules/metabolism ; Mitochondria/metabolism ; Golgi Apparatus/metabolism ; Endoplasmic Reticulum/metabolism ; Movement ; Cytoplasmic Streaming
Περίληψη: Organelle movements in plants are driven by myosin XI motors moving along the actin filament cytoskeleton. Several experiments have suggested that indirect effects such as organelle-organelle interactions or hydrodynamic flow might be responsible for organelle movements. To test these models, we altered the motile behavior of specific organelles in Nicotiana benthamiana leaf epidermal cells and examined the effects of these perturbations on other organelles. Recruiting myosins to organelles with 'Booster' constructs resulted in significant increases of linear motions, whereas binding organelles to cortical microtubules with 'Anchor' constructs lead to diminished movements of the targeted mitochondria, peroxisomes and ER, respectively. We did not observe consistent effects of Anchor constructs on non-targeted organelles. Mitochondrial Boosters increased the motility of all tested organelles, presumably by leading to a reorganization of actin filaments. By contrast, ER Boosters resulted in enhanced movements for only Golgi stacks and peroxisomes, suggesting a specific interaction between these organelles. Collectively, this novel engineering approach to modify the movements of specific organelles demonstrates that organelle motility in plant cells can occur independently but nevertheless is coordinated between different types of organelles.
(© 2026. Published by The Company of Biologists.)
Competing Interests: Competing interests The authors declare no competing or financial interests.
Grant Information: 1715794 Division of Molecular and Cellular Biosciences; MCB-1715794 National Science Foundation; University of Tennessee at Knoxville
Contributed Indexing: Keywords: Actin filaments; Cytoplasmic streaming; Myosin XI; Organelle movements
Substance Nomenclature: EC 3.6.4.1 (Myosins)
Entry Date(s): Date Created: 20260824 Date Completed: 20260925 Latest Revision: 20260925
Update Code: 20260925
DOI: 10.1242/jcs.264573
PMID: 42634869
Βάση Δεδομένων: MEDLINE
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  Data: Accelerated organelle movements can indirectly affect the motility of other organelles in plant cells.
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  Data: <searchLink fieldCode="AU" term="%22Gu+JM%22">Gu JM</searchLink>; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA.<br /><searchLink fieldCode="AU" term="%22Keith+A%22">Keith A</searchLink>; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA.<br /><searchLink fieldCode="AU" term="%22Smith+K%22">Smith K</searchLink>; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA.<br /><searchLink fieldCode="AU" term="%22Nebenführ+A%22">Nebenführ A</searchLink>; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996-1939, USA.
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  Data: <searchLink fieldCode="JN" term="%220052457%22">Journal of cell science</searchLink> [J Cell Sci] 2026 Sep 15; Vol. 139 (18). <i>Date of Electronic Publication: </i>2026 Sep 25.
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  Data: Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Company+of+Biologists%22">Company of Biologists </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0052457 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-9137 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219533%22">00219533 </searchLink><i>NLM ISO Abbreviation: </i>J Cell Sci <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: Cambridge : Company of Biologists<br /><i>Original Publication</i>: London.
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  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Nicotiana%22">Nicotiana*</searchLink>/<searchLink fieldCode="MM" term="%22Nicotiana+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Nicotiana%22">Nicotiana*</searchLink>/<searchLink fieldCode="MM" term="%22Nicotiana+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Organelles%22">Organelles*</searchLink>/<searchLink fieldCode="MM" term="%22Organelles+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Cells%22">Plant Cells*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Cells+metabolism%22">metabolism</searchLink><br /><searchLink fieldCode="MH" term="%22Peroxisomes%22">Peroxisomes</searchLink>/<searchLink fieldCode="MH" term="%22Peroxisomes+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Myosins%22">Myosins</searchLink>/<searchLink fieldCode="MH" term="%22Myosins+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Actin+Cytoskeleton%22">Actin Cytoskeleton</searchLink>/<searchLink fieldCode="MH" term="%22Actin+Cytoskeleton+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Microtubules%22">Microtubules</searchLink>/<searchLink fieldCode="MH" term="%22Microtubules+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Mitochondria%22">Mitochondria</searchLink>/<searchLink fieldCode="MH" term="%22Mitochondria+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Golgi+Apparatus%22">Golgi Apparatus</searchLink>/<searchLink fieldCode="MH" term="%22Golgi+Apparatus+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Endoplasmic+Reticulum%22">Endoplasmic Reticulum</searchLink>/<searchLink fieldCode="MH" term="%22Endoplasmic+Reticulum+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Movement%22">Movement</searchLink> ; <searchLink fieldCode="MH" term="%22Cytoplasmic+Streaming%22">Cytoplasmic Streaming</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Organelle movements in plants are driven by myosin XI motors moving along the actin filament cytoskeleton. Several experiments have suggested that indirect effects such as organelle-organelle interactions or hydrodynamic flow might be responsible for organelle movements. To test these models, we altered the motile behavior of specific organelles in Nicotiana benthamiana leaf epidermal cells and examined the effects of these perturbations on other organelles. Recruiting myosins to organelles with 'Booster' constructs resulted in significant increases of linear motions, whereas binding organelles to cortical microtubules with 'Anchor' constructs lead to diminished movements of the targeted mitochondria, peroxisomes and ER, respectively. We did not observe consistent effects of Anchor constructs on non-targeted organelles. Mitochondrial Boosters increased the motility of all tested organelles, presumably by leading to a reorganization of actin filaments. By contrast, ER Boosters resulted in enhanced movements for only Golgi stacks and peroxisomes, suggesting a specific interaction between these organelles. Collectively, this novel engineering approach to modify the movements of specific organelles demonstrates that organelle motility in plant cells can occur independently but nevertheless is coordinated between different types of organelles.<br /> (© 2026. Published by The Company of Biologists.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Competing interests The authors declare no competing or financial interests.
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  Label: Grant Information
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  Data: 1715794 Division of Molecular and Cellular Biosciences; MCB-1715794 National Science Foundation; University of Tennessee at Knoxville
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Actin filaments; Cytoplasmic streaming; Myosin XI; Organelle movements
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: EC 3.6.4.1 (Myosins)
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  Data: <i>Date Created: </i>20260824 <i>Date Completed: </i>20260925 <i>Latest Revision: </i>20260925
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  Data: 10.1242/jcs.264573
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  Data: 42634869
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42634869
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    Identifiers:
      – Type: doi
        Value: 10.1242/jcs.264573
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Peroxisomes metabolism
        Type: general
      – SubjectFull: Myosins metabolism
        Type: general
      – SubjectFull: Actin Cytoskeleton metabolism
        Type: general
      – SubjectFull: Microtubules metabolism
        Type: general
      – SubjectFull: Mitochondria metabolism
        Type: general
      – SubjectFull: Golgi Apparatus metabolism
        Type: general
      – SubjectFull: Endoplasmic Reticulum metabolism
        Type: general
      – SubjectFull: Movement
        Type: general
      – SubjectFull: Cytoplasmic Streaming
        Type: general
      – SubjectFull: Nicotiana metabolism
        Type: general
      – SubjectFull: Nicotiana cytology
        Type: general
      – SubjectFull: Organelles metabolism
        Type: general
      – SubjectFull: Plant Cells metabolism
        Type: general
    Titles:
      – TitleFull: Accelerated organelle movements can indirectly affect the motility of other organelles in plant cells.
        Type: main
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            NameFull: Keith A
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              Text: 2026 Sep 15
              Type: published
              Y: 2026
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              Value: 18
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            – TitleFull: Journal of cell science
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