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Heritable and experience-dependent cortical traits of reading ability.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Heritable and experience-dependent cortical traits of reading ability.
Συγγραφείς: Roll M; Centre for Languages and Literature, Lund University, Helgonabacken 12, 223 62 Lund, Sweden.
Πηγή: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2026 Aug 01; Vol. 36 (8).
Τύπος έκδοσης: Journal Article; Twin Study; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, NY : Oxford University Press, c1991-
Ιατρικοί όροι (MeSH): Cerebral Cortex*/physiology , Cerebral Cortex*/diagnostic imaging , Cerebral Cortex*/anatomy & histology , Reading*, Auditory Cortex/physiology ; Auditory Cortex/diagnostic imaging ; Dyslexia/genetics ; Humans ; Female ; Male ; Young Adult ; Adult ; Semantics ; Magnetic Resonance Imaging ; Brain Mapping
Περίληψη: Reading ability emerges from interacting phonological and semantic skills. However, the cortical microstructure supporting these traits remains unclear. Multimodal cortical parcellation and diffusion analysis were performed in 1,068 participants, including a genetically informed twin subsample. We identified auditory and anterior temporal subregions predicting oral reading scores. In the left auditory cortex, myelin in a paralemniscal (belt) area was heritably linked to reading, whereas thickness in the lemniscal (core) region reflected experience-dependent contributions. Bilateral anterior temporal lobe (ATL) surface areas were genetically associated with reading and predicted semantic performance, providing novel cortical evidence for heritable semantic substrates of literacy. The left inferior fronto-occipital fasciculus and a left ATL region connected with the arcuate fasciculus predicted reading scores independent of genetic influences. The cortical traits were linked to reading continuously across the population, challenging categorical models of dyslexia. The findings suggest that genetic and experience-dependent mechanisms jointly shape the phonological and semantic foundations of literacy.
(© The Author(s) 2026. Published by Oxford University Press.)
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Grant Information: U54 MH091657 United States MH NIMH NIH HHS; 2017.0006 Crafoord Foundation; 2018.00632 Swedish Research Council; 2018.0454 Knut and Alice Wallenberg Foundation
Contributed Indexing: Keywords: anterior temporal lobe; auditory cortex; cortical microstructure; heritability; reading
Entry Date(s): Date Created: 20260822 Date Completed: 20260822 Latest Revision: 20260930
Update Code: 20260930
PubMed Central ID: PMC13575274
DOI: 10.1093/cercor/bhag125
PMID: 42632036
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1460-2199
DOI:10.1093/cercor/bhag125