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Psychometric validation of research domain criteria, general health, and clinical-psychosocial parts of the minimum dataset of the German Center for Mental Health-informing a Delphi process.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Psychometric validation of research domain criteria, general health, and clinical-psychosocial parts of the minimum dataset of the German Center for Mental Health-informing a Delphi process.
Συγγραφείς: Förstner BR; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Mühlenberg 9, 14476, Potsdam, Germany. bernd.foerstner@uni-potsdam.de.; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany. bernd.foerstner@uni-potsdam.de., Böttger SJ; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Mühlenberg 9, 14476, Potsdam, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany., Seegert T; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Mühlenberg 9, 14476, Potsdam, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany., Kerber A; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany.; Division of Clinical Psychosocial Intervention, Freie Universität Berlin, Berlin, Germany., Terhorst Y; Department of Psychology, LMU Munich, Munich, Germany.; German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany., Heinz A; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.; Department of Psychiatry and Psychotherapy and CRC TR 265, TU Dresden, Dresden, Germany., Dziobek I; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany.; Klinische Psychologie Sozialer Interaktion, Institut Für Psychologie, Humboldt-Universität Zu Berlin, Berlin, Germany., Voigt B; German Center for Mental Health (DZPG), Partner Site Bochum/Marburg, Bochum, Germany.; Mental Health Research and Treatment Center (FBZ), Ruhr University Bochum, Bochum, Germany., Schneider S; German Center for Mental Health (DZPG), Partner Site Bochum/Marburg, Bochum, Germany.; Department of Clinical Child and Adolescent Psychology, Ruhr-University Bochum, Bochum, Germany., Opel N; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany.; Department of Psychiatry & Neuroscience, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany., Walter M; German Center for Mental Health (DZPG), Partner Site Halle/Jena/Magdeburg, Jena, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Braun U; German Center for Mental Health (DZPG), Partner Site Mannheim/Heidelberg/Ulm, Mannheim, Germany.; Central Institute for Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Meyer-Lindenberg A; German Center for Mental Health (DZPG), Partner Site Mannheim/Heidelberg/Ulm, Mannheim, Germany.; Central Institute for Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Koutsouleris N; German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Falkai P; German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Schmitz N; German Center for Mental Health (DZPG), Partner Site Tübingen, Tübingen, Germany.; Population-Based Medicine, University of Tübingen, Tübingen, Germany., Fallgatter AJ; German Center for Mental Health (DZPG), Partner Site Tübingen, Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Sünkel U; German Center for Mental Health (DZPG), Central Trialogical Board, Berlin, Germany.; German Center for Mental Health (DZPG), Partner Site Tübingen, Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Lipinski S; German Center for Mental Health (DZPG), Central Trialogical Board, Berlin, Germany.; Humboldt-Universität Zu Berlin, Berlin, Germany., Rapp MA; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Mühlenberg 9, 14476, Potsdam, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany., Tschorn M; Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Am Mühlenberg 9, 14476, Potsdam, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin/Potsdam, Potsdam, Germany.
Συλλογικό Έργο: MDS Expert Group List
Πηγή: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2026 Oct; Vol. 276 (7), pp. 3563-3582. Date of Electronic Publication: 2026 Aug 22.
Τύπος έκδοσης: Journal Article; Validation Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: Germany NLM ID: 9103030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8491 (Electronic) Linking ISSN: 09401334 NLM ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin ; New York : Springer International, c1990-
Ιατρικοί όροι (MeSH): Psychometrics*/standards , Mental Disorders*/diagnosis , Datasets as Topic*/standards , Delphi Technique*, Humans ; Germany ; Female ; Adult ; Male ; Factor Analysis, Statistical ; Middle Aged ; Reproducibility of Results ; Young Adult
Περίληψη: Objective: This study evaluated the latent structure and conceptual validity of the Research Domain Criteria (RDoC), General Health, and Clinical/Psychosocial clusters of the German Center for Mental Health (DZPG) Minimum Data Set (MDS). It aimed to determine whether these clusters represent interpretable constructs and demonstrate cross-group comparability across clinical and non-clinical populations, providing a data-driven basis for item selection within a Delphi consensus process.
Methods: Two subsamples were analyzed: a representative sample (N = 2,287) and a clinic-recruited sample (N = 322) from six DZPG sites. Multi-group confirmatory factor analyses tested the latent structure and assessed configural, metric, and scalar measurement invariance between non-clinical vs. clinical/help-seeking groups.
Results: All three MDS clusters demonstrated excellent baseline model fit (RDoC: CFI = .990, RMSEA = .037; General Health: CFI = .993, RMSEA = .037; Clinical/Psychosocial factors: CFI = .992, RMSEA = .026). Analyses confirmed configural and scalar invariance across all clusters but indicated non-invariance at the metric level for the General Health cluster.
Conclusions: The results provide initial evidence for the structural validity and cross-group comparability of the RDoC and Clinical/Psychosocial clusters, while indicating limitations regarding metric non-invariance within the General Health cluster. They informed a Delphi consensus process and support the MDS as a scalable framework for diverse populations, particularly relevant for the DZPG's effort to harmonize mental health data across institutions and contexts.
(© 2026. The Author(s).)
Competing Interests: Declarations. Conflict of interest: MW is a member of the following advisory boards and gave presentations to the following companies: Bayer AG, Germany; Janssen, Boehringer Ingelheim, Germany; Novartis, Perception Neuroscience, HMNC and Biologische Heilmittel Heel GmbH, Germany. All other authors report no competing interests. All other authors report no competing interests. Ethical approval: This DZPG project was positively evaluated by the ethics committee of the University of Potsdam (Nr. 6/2016 Addendum MDS-Valid (1. 62/2019) and was conducted in accordance with the latest version of the Declaration of Helsinki. Consent to participate/consent for publication: All subjects gave written informed consent to participate in and contribute their data in an anonymized fashion in all surveys used.
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Grant Information: United Kingdom WT_ Wellcome Trust
Contributed Indexing: Investigator: V Birgel; A Braun; C Correll; C Cohrdes; S Entringer; P Gellert; MG Halil; S Hädel; C Heim; C Knaevelsrud; J Kraft; S Ripke; M Rose; H Walter; J Brailovskaia; B Bredenbröcker; R Kumsta; M Luhmann; J Margraf; F Räder; S Schaumburg; S Seehagen; I Croy; K Lind; R Mikolajczyk; F Rottstädt; LA Steinmann; S Bauer; SC Herpertz; P Kling; K Kubera; B Lenz; U Reininghaus; C Rauschenberg; E Schwarz; H Tost; M Wilhelm; K Bertsch; T Ehring; P Henningsen; S Leucht; I Maurus; F Padberg; A Ruef; G Eschweiler; V Nieratschker; A Stengel; S Zipfel; M Bea; R Hannig; FJ Wagner; N Boyce; D Cicero; B Cuthbert; O Godin; U Habel; M Leboyer; W Lutz; I Maurus; M Mund; J Pacheco; A Rogge; S Roose; MH Soto
Keywords: DZPG; German Center for Mental Health; MDS; MGCFA; Minimum Dataset; Transdiagnostic
Entry Date(s): Date Created: 20260822 Date Completed: 20260910 Latest Revision: 20260918
Update Code: 20260918
PubMed Central ID: PMC13562200
DOI: 10.1007/s00406-026-02315-w
PMID: 42631718
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1433-8491
DOI:10.1007/s00406-026-02315-w