Academic Journal
Cave evolution on repeat: reuse of the same genomic regions across lineages of Astyanax mexicanus.
| Τίτλος: | Cave evolution on repeat: reuse of the same genomic regions across lineages of Astyanax mexicanus. |
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| Συγγραφείς: | Richards EJ; Department of Ecology, Evolution, and Behavior, University of Minnesota, 123 Snyder Hall 1475 Gortner Ave, Saint Paul, MN 55108, United States., Moran RL; Department of Ecology & Evolution, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, United States., Wiese J; Department of Ecology & Evolution, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, United States., O'Gorman M; Department of Biology, Texas A&M University, 400 Bizzell Street, College Station, TX 77843, United States., Hutton P; Department of Biology, Texas A&M University, 400 Bizzell Street, College Station, TX 77843, United States., Rastogi A; Department of Biology, Texas A&M University, 400 Bizzell Street, College Station, TX 77843, United States., North OW; Department of Biology, Texas A&M University, 400 Bizzell Street, College Station, TX 77843, United States., Manning AE; Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, United States., Roback EY; Department of Ecology, Evolution, and Behavior, University of Minnesota, 123 Snyder Hall 1475 Gortner Ave, Saint Paul, MN 55108, United States., Kowalko JE; Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, United States., Rohner N; Institute of Integrative Cell Biology and Physiology, University of Münster, Schlossplatz 8, Münster, North Rhine-Westphalia 48149, Germany., Keene AC; Department of Biology, Texas A&M University, 400 Bizzell Street, College Station, TX 77843, United States., McGaugh SE; Department of Ecology, Evolution, and Behavior, University of Minnesota, 123 Snyder Hall 1475 Gortner Ave, Saint Paul, MN 55108, United States. |
| Πηγή: | Genetics [Genetics] 2026 Oct 07; Vol. 234 (2). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: Austin, Tex. [etc.] |
| Ιατρικοί όροι (MeSH): | Characidae*/genetics , Quantitative Trait Loci* , Biological Evolution* , Evolution, Molecular*, Animals ; Caves ; Phenotype ; Genome |
| Περίληψη: | Similar traits repeatedly evolve across independent populations in response to similar environmental conditions. For many repeatedly evolved traits, it is unknown if populations evolve similar traits through the same or different genetic mechanisms. To address this question, we leveraged the Mexican tetra fish, Astyanax mexicanus, which has repeatedly evolved many traits including reduced sleep duration, eye degeneration, and metabolic shifts to accommodate limited nutrient availability. We defined whether shared or independent genetic architecture governs the repeated evolution of sleep loss, increased food consumption, early onset adipose deposition, and eye loss in different evolutionary origins of the cavefish phenotype by using quantitative trait locus (QTL) mapping across 3 cave × surface F2 hybrid populations. We found that, among the traits evaluated, eye loss exhibits the most genetic repeatability, with ∼43% of QTL shared across lineages. Sleep loss and metabolic traits (ie feeding, adiposity) were genetically less repeatable, with only ∼25% to 33% of QTL shared across lineages. Next, we explored whether QTL for metabolism, eye loss, and sleep traits in cavefish colocalize in the cavefish genome and are inherited together to facilitate potential cavefish adaptation. Although these traits have repeatedly co-evolved in cave populations, we did not find evidence for extensive genetic linkage among them. Overall, we found that genetic repeatability is a common feature in the repeated evolution of cave traits, the extent of genetic repeatability varies across cave traits, and there is little evidence for widespread colocalization of sleep, eye loss, and metabolic traits within the genome. (© The Author(s) 2026. Published by Oxford University Press on behalf of The Genetics Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Competing Interests: | Conflicts of interest: All authors declare that they have no known competing financial or personal interests that would influence the work shown in this manuscript. |
| Σχόλια: | Update of: bioRxiv. 2026 Feb 03:2026.01.31.703033. doi: 10.64898/2026.01.31.703033.. (PMID: 41676532) |
| Grant Information: | R01GM127872 United States NH NIH HHS; R35GM138345 United States NH NIH HHS; 2316783/2316784 National Science Foundation; R01GM127872 National Science Foundation; DEB-2316783 National Science Foundation |
| Contributed Indexing: | Keywords: cave evolution; genetic basis of sleep; quantitative trait loci; repeated evolution; trait co-evolution |
| Entry Date(s): | Date Created: 20260822 Date Completed: 20261007 Latest Revision: 20261009 |
| Update Code: | 20261009 |
| PubMed Central ID: | PMC13643756 |
| DOI: | 10.1093/genetics/iyag223 |
| PMID: | 42631504 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1943-2631 |
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| DOI: | 10.1093/genetics/iyag223 |