Academic Journal
The dynamics of cerebral blood flow and cerebral oedema evaluated by MRI following resuscitation from cardiac arrest; a porcine study.
| Τίτλος: | The dynamics of cerebral blood flow and cerebral oedema evaluated by MRI following resuscitation from cardiac arrest; a porcine study. |
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| Συγγραφείς: | Johannsen CM; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark., Lund MH; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark., Kridal S; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark., Kjærsgaard L; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark., Hermann KØ; Department of Clinical Medicine, Aarhus University, Denmark., Risager BH; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark., Svalgaard AD; Department of Clinical Medicine, Aarhus University, Denmark., Stæhr C; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark; Center of Functionally Integrative Neuroscience, Aarhus University, Denmark., Vammen L; Department of Anaesthesiology and Intensive Care, Randers Regional Hospital, Denmark., Christensen NV; Department of Clinical Medicine, Aarhus University, Denmark; MR Research Centre, Aarhus University, Denmark., Szocska Hansen ES; Department of Clinical Medicine, Aarhus University, Denmark; MR Research Centre, Aarhus University, Denmark., Ringgaard S; Department of Clinical Medicine, Aarhus University, Denmark; MR Research Centre, Aarhus University, Denmark., Laustsen C; Department of Clinical Medicine, Aarhus University, Denmark; MR Research Centre, Aarhus University, Denmark; Department of Radiology, University of Cambridge, Cambridge, UK., Andersen L; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark; Prehospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark., Granfeldt A; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark. Electronic address: granfeldt@clin.au.dk. |
| Πηγή: | Resuscitation [Resuscitation] 2026 Oct; Vol. 227, pp. 111273. Date of Electronic Publication: 2026 Aug 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/north-Holland Biomedical Press Country of Publication: Ireland NLM ID: 0332173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1570 (Electronic) Linking ISSN: 03009572 NLM ISO Abbreviation: Resuscitation Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier/north-Holland Biomedical Press Original Publication: London, Middlesex Pub. Co. |
| Ιατρικοί όροι (MeSH): | Brain Edema*/etiology , Brain Edema*/diagnostic imaging , Brain Edema*/physiopathology , Heart Arrest*/therapy , Heart Arrest*/complications , Heart Arrest*/physiopathology , Cerebrovascular Circulation*/physiology , Cardiopulmonary Resuscitation*/methods, Animals ; Swine ; Magnetic Resonance Imaging ; Disease Models, Animal ; Female ; Random Allocation |
| Περίληψη: | Purpose: To investigate changes in cerebral perfusion and cerebral oedema following cardiac arrest over a 24-h period. Method: Sixteen pigs were randomised to two groups: cardiac arrest group (n = 10) and sham group (n = 6). The cardiac arrest group was subjected to myocardial infarction and 9 min of untreated cardiac arrest. Cerebral blood flow and oedema were evaluated by repeated magnetic resonance imaging (MRI) at 3, 6, 12, and 24 h after achieving return of spontaneous circulation (ROSC). Sham pigs underwent MRI scans at corresponding time points. Results: Global cerebral blood flow was lower in the cardiac arrest group with a mean group difference of 14.1 mL 100 g-1 min-1 (95% CI: 1.1-27.1; p = 0.028) at 6 h and 15.1 mL 100 g-1 min-1 (95% CI: 1.9-28.3; p = 0.018) at 12 h. Indications of cytotoxic oedema were present at 6 h in the form of lower apparent diffusion coefficient in the cardiac arrest group in the left cortex with a mean difference of 57.8·10-6 mm2/s (95% CI: 12.8-102.8; p = 0.006) and in the right cortex with a mean difference of 64.4 10-6 mm2/s (95% CI: 21.3-107.5; p = 0.001). Neuronal damage was evident by higher neuron specific enolase at 24 h in the cardiac arrest group with a mean difference of -1.14 μg/L (95% CI: -1.77 to -0.50; p < 0.001). Conclusion: We have demonstrated time-dependent cerebral hypoperfusion and region-specific cytotoxic oedema. Our results suggest that cerebral perfusion and cerebral oedema are potential targets of neuroprotection and their development can be evaluated by MRI. (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest Co-author Lars Andersen, MD, MPH, PhD, DMSc is part of Resuscitation’s Editorial Board. The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Acute myocardial infarction; Animal experiment; Heart arrest; Neurological injury |
| Entry Date(s): | Date Created: 20260820 Date Completed: 20260923 Latest Revision: 20260923 |
| Update Code: | 20260924 |
| DOI: | 10.1016/j.resuscitation.2026.111273 |
| PMID: | 42624196 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-1570 |
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| DOI: | 10.1016/j.resuscitation.2026.111273 |