Academic Journal
Integration of multi-stacked biodegradable PLGA membranes into microfluidic organ-on-a-chip devices for tunable barrier co-culture.
| Τίτλος: | Integration of multi-stacked biodegradable PLGA membranes into microfluidic organ-on-a-chip devices for tunable barrier co-culture. |
|---|---|
| Συγγραφείς: | Kim M; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah 84112, USA. jkim@mech.utah.edu., Choi K; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah 84112, USA. jkim@mech.utah.edu., Park K; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah 84112, USA. jkim@mech.utah.edu., Al-Rabadi L; Division of Nephrology, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah 84112, USA., Chang J; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah 84112, USA. jkim@mech.utah.edu., Kim J; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah 84112, USA. jkim@mech.utah.edu.; Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.; Department of Biomedical Engineering, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. |
| Πηγή: | Lab on a chip [Lab Chip] 2026 Sep 16; Vol. 26 (18), pp. 4830-4840. Date of Electronic Publication: 2026 Sep 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, UK : Royal Society of Chemistry, c2001- |
| Ιατρικοί όροι (MeSH): | Polyglycolic Acid*/chemistry , Lactic Acid*/chemistry , Microfluidic Analytical Techniques*/instrumentation , Membranes, Artificial* , Lab-On-A-Chip Devices*, Coculture Techniques/instrumentation ; Polylactic Acid-Polyglycolic Acid Copolymer ; Porosity ; Animals ; Humans ; Microphysiological Systems ; Permeability |
| Περίληψη: | We integrate multi-stacked, thermally fused near-field electrospun PLGA membranes into a microfluidic organ-on-a-chip device. Layer number controls pore diameter (12-33 μm), porosity, circularity and permeability. The biodegradable, optically transparent membranes support endothelial-stromal co-culture with confirmed barrier integrity (TEER, ZO-1) and spatially resolved tissue compartmentalization. |
| Substance Nomenclature: | 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 26009-03-0 (Polyglycolic Acid) 33X04XA5AT (Lactic Acid) 0 (Membranes, Artificial) |
| Entry Date(s): | Date Created: 20260818 Date Completed: 20260916 Latest Revision: 20260916 |
| Update Code: | 20260916 |
| DOI: | 10.1039/d6lc00296j |
| PMID: | 42609170 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1473-0189 |
|---|---|
| DOI: | 10.1039/d6lc00296j |