Academic Journal
Regression of Left Ventricular Hypertrophy in Primary Aldosteronism.
| Τίτλος: | Regression of Left Ventricular Hypertrophy in Primary Aldosteronism. |
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| Συγγραφείς: | Goi J; Department of Endocrinology and Nutrition (J.G., M.A.-C.), Hospital Universitario Ramón y Cajal, Madrid, Spain., Burrello J; Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy (J.B., V.C., P.M.)., Schneider H; Division of Endocrinology, Department of Medicine IV (H.S., E.J.P., S.Z., M. Reincke), LMU University Hospital, Munich, Germany.; Division of Vascular Medicine, Department of Medicine IV (H.S.), LMU University Hospital, Munich, Germany., Petersenn EJ; Division of Endocrinology, Department of Medicine IV (H.S., E.J.P., S.Z., M. Reincke), LMU University Hospital, Munich, Germany., Zopp S; Division of Endocrinology, Department of Medicine IV (H.S., E.J.P., S.Z., M. Reincke), LMU University Hospital, Munich, Germany., Capuzzo V; Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy (J.B., V.C., P.M.)., García Cano AM; Department of Biochemistry (A.M.G.C., L.C.G.), Hospital Universitario Ramón y Cajal, Madrid, Spain., Caja Guayerbas L; Department of Biochemistry (A.M.G.C., L.C.G.), Hospital Universitario Ramón y Cajal, Madrid, Spain., Mena Ribas E; Department of Endocrinology and Nutrition, Hospital Universitario Son Espases, Palma, Islas Baleares, Spain (E.M.R., A.S.S.)., Sanmartín Sánchez A; Department of Endocrinology and Nutrition, Hospital Universitario Son Espases, Palma, Islas Baleares, Spain (E.M.R., A.S.S.)., Parra Ramírez P; Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain (P.P.R., P.M.R.-M.)., Martín Rojas-Marcos P; Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain (P.P.R., P.M.R.-M.)., Paja Fano M; Department of Endocrinology and Nutrition, OSI Bilbao-Basurto, Hospital Universitario de Basurto, Spain (M.P.F.).; University of the Basque Country UPV/EHU, Bilbao, Spain (M.P.F.)., Díaz Guardiola P; Department of Endocrinology and Nutrition, Hospital Universitario Infanta Sofía, Madrid, Spain (P.D.G.)., Rebollo Román Á; Department of Endocrinology and Nutrition, Hospital Universitario Reina Sofía, Córdoba, Spain (A.R.R.)., Moya Mateo EM; Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain (E.M.M.M.)., Gabriel Ruiz-Sanchez J; Department of Endocrinology and Nutrition, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain (J.G.R.-S.)., González-Boillos M; Department of Endocrinology and Nutrition, Hospital Universitario de Castellón, Spain (M.G.-B.)., Jaén Aguila F; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain (F.J.A.)., Perdomo CM; Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain (C.M.P.)., Robles Lázaro C; Department of Endocrinology and Nutrition, Hospital Clínico Universitario de Salamanca, Spain (C.R.L.)., Recasens M; Department of Endocrinology and Nutrition, Hospital de Girona Doctor Josep Trueta, Spain (M. Recasens, R.B.S.M.)., Barahona San Millan R; Department of Endocrinology and Nutrition, Hospital de Girona Doctor Josep Trueta, Spain (M. Recasens, R.B.S.M.)., Gómez-Hoyos E; Department of Endocrinology and Nutrition, Hospital Universitario de Valladolid, Spain (E.G.-H.)., Picón César MJ; Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria de Málaga, IBIMA, Spain (M.J.P.C.)., Gutiérrez-Medina S; Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Madrid, Spain (S.G.-M.)., Lamas C; Department of Endocrinology and Nutrition, Hospital Universitario de Albacete, Spain (C.L.)., Casteras A; Department of Endocrinology and Nutrition, Hospital Universitario Val d'Hebron, Barcelona, Spain (A.C.)., Mulatero P; Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy (J.B., V.C., P.M.)., Reincke M; Division of Endocrinology, Department of Medicine IV (H.S., E.J.P., S.Z., M. Reincke), LMU University Hospital, Munich, Germany., Araujo-Castro M; Department of Endocrinology and Nutrition (J.G., M.A.-C.), Hospital Universitario Ramón y Cajal, Madrid, Spain.; Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain (M.A.-C.). |
| Συλλογικό Έργο: | Adrenal Working Group of the Spanish Society of Endocrinology & Nutrition (SEEN) |
| Πηγή: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 2026 Oct; Vol. 83 (10), pp. e26909. Date of Electronic Publication: 2026 Aug 17. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| Ιατρικοί όροι (MeSH): | Adrenalectomy*/methods , Hyperaldosteronism*/complications , Hyperaldosteronism*/therapy , Hypertrophy, Left Ventricular*/diagnostic imaging , Hypertrophy, Left Ventricular*/epidemiology , Hypertrophy, Left Ventricular*/etiology , Hypertrophy, Left Ventricular*/therapy , Mineralocorticoid Receptor Antagonists*/therapeutic use, Aldosterone/blood ; Echocardiography/methods ; Europe/epidemiology ; Adult ; Female ; Humans ; Male ; Middle Aged ; Follow-Up Studies ; Prevalence ; Retrospective Studies ; Treatment Outcome ; Ventricular Remodeling ; Remission Induction |
| Περίληψη: | Background: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist (MRA) therapy, identified determinants of LVH regression, and evaluated the relationship between patients' outcomes and cardiac remodeling. Methods: We retrospectively analyzed an international cohort of patients with primary aldosteronism from 36 referral centers in Spain, Italy, and Germany. Echocardiographic recordings were included at baseline and after at least 1 year of targeted treatment. Regression models were applied to identify parameters associated with LVH regression and changes in left ventricular mass index. Results: Among 1454 patients (mean age, 51 years; 58.7% men) with primary aldosteronism, baseline LVH prevalence was 49.4%. Aldosterone, blood pressure, male sex, number of antihypertensive medications, and diabetes were associated with LVH. Of 473 patients with follow-up echocardiography, 33.6% underwent adrenalectomy, 61.7% received MRA, and 4.7% were taking MRA postsurgery. After a median follow-up of 51 months, LVH regression was observed in 54.2% of patients (61.9% after adrenalectomy versus 48.6% with MRA treatment; P=0.043), and left ventricular mass index significantly decreased after both surgery and medical therapy. Higher pretreatment blood pressure and aldosterone levels were associated with a lower likelihood of LVH regression, regardless of treatment modality. Complete biochemical success was associated with greater left ventricular mass index reduction at follow-up. Conclusions: LVH regressed in over half the patients after targeted treatment, with left ventricular mass index decreasing after both adrenalectomy and MRA therapy. Baseline aldosterone levels were associated with LVH regression, independently of blood pressure load. |
| Competing Interests: | None. |
| Contributed Indexing: | Keywords: adrenalectomy; aldosterone; blood pressure; hyperaldosteronism; hypertrophy; left ventricular; mineralocorticoid receptor antagonists |
| Substance Nomenclature: | 4964P6T9RB (Aldosterone) 0 (Mineralocorticoid Receptor Antagonists) |
| Entry Date(s): | Date Created: 20260817 Date Completed: 20260916 Latest Revision: 20260930 |
| Update Code: | 20261001 |
| DOI: | 10.1161/HYPERTENSIONAHA.126.26909 |
| PMID: | 42605678 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1524-4563 |
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| DOI: | 10.1161/HYPERTENSIONAHA.126.26909 |