Academic Journal
Applicability of the Vreeman-Sun equation - power law mixing rule (VS-PL) model for predicting tabletability of mixtures.
| Τίτλος: | Applicability of the Vreeman-Sun equation - power law mixing rule (VS-PL) model for predicting tabletability of mixtures. |
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| Συγγραφείς: | Wang Z; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Bristol Myers Squibb, 1 Squibb Dr, New Brunswick, NJ 08901, USA., Bhagali V; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Serán BioScience, 63040 Lower Meadow Dr, Bend, OR 97701, USA., Vreeman G; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA., Hasabnis A; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA., Sun CC; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Department of Industrial and Molecular Pharmaceutics, Purdue University, Robert E. Heine Pharmacy Building, 124C, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address: sun1456@purdue.edu. |
| Πηγή: | International journal of pharmaceutics [Int J Pharm] 2026 Oct 05; Vol. 703, pp. 127314. Date of Electronic Publication: 2026 Aug 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Tablets*/chemistry , Excipients*/chemistry , Models, Theoretical*, Stearic Acids/chemistry ; Powders/chemistry ; Chemistry, Pharmaceutical/methods ; Drug Compounding/methods ; Particle Size ; Bulk Drugs |
| Περίληψη: | Tabletability, which quantifies a powder's ability to be transformed into a tablet with a specified mechanical strength under an applied compaction pressure, is a critical material property in tablet formulation development. A predictive model based on the Vreeman-Sun equation, combined with a power-law mixing rule (VS-PL), has recently been proposed to estimate the tabletability of binary mixtures from those of individual components. In this study, the applicability of this model across diverse materials and formulation conditions was systematically evaluated using sixty unique binary mixtures, two ternary mixtures, and one five-component system comprising common pharmaceutical excipients and active pharmaceutical ingredients. The model demonstrated good predictive performance for most binary mixtures and accurately predicted the tabletability of the ternary mixtures and the quinary formulation. Particle size variation (30-180 µm) was found to have minimal impact on model performance within the investigated systems, and the model was applicable to formulations lubricated with magnesium stearate. However, predictions were less reliable for formulations involving very hard materials and compositions below the percolation threshold. Despite these limitations, the predictive framework has the potential to facilitate material-sparing and efficient digital design of high-quality tablet formulations. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Digital design; Mixture prediction; Powders; Tablet formulation; Tabletability |
| Substance Nomenclature: | 0 (Tablets) 0 (Excipients) 0 (Stearic Acids) 0 (Powders) 4ELV7Z65AP (stearic acid) 0 (Bulk Drugs) |
| Entry Date(s): | Date Created: 20260815 Date Completed: 20260919 Latest Revision: 20260919 |
| Update Code: | 20260920 |
| DOI: | 10.1016/j.ijpharm.2026.127314 |
| PMID: | 42603575 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2026.127314 |