Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.
Συγγραφείς:	Liu E; Department of Radiology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Sun F; Department of Orthopedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Peng D; Department of Orthopedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Xu W; Department of Orthopedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Zou Q; School of Medical Imaging, Changsha Medical University, Changsha, Hunan, China., Chen X; Department of Orthopedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Wu X; Department of Radiology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Πηγή:	Medicine [Medicine (Baltimore)] 2026 Aug 14; Vol. 105 (33), pp. e50178.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
Imprint Name(s):	Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
Ιατρικοί όροι (MeSH):	Hand Strength/physiology , Feeding Behavior/physiology , Mendelian Randomization Analysis*, Humans ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
Περίληψη:	A large number of studies have shown a close association between dietary habits and low hand grip strength. However, the presence of a causal connection between dietary habits and low hand grip strength remains unclear. All genome-wide association studies of dietary habits summary statistics were run in BOLT-LMM software (Broad Institute) using linear mixed models with 10 genetic principal components and genotyping array as covariates, and all phenotypes were averaged over multiple Food Frequency Questionnaires, adjusted for age and sex, and inverse normal transformed. The extracted single nucleotide polymorphisms explored the relationship between dietary habits and low hand grip strength by inverse variance weighted (IVW), Mendelian randomization-Egger (MR-Egger), and MR-pleiotropy residual sum and outlier. IVW estimates indicated that different dietary habits had a causal association with low hand grip strength, including drinking currently with various meals (beta: -0.432, 95% confidence interval [CI]: -0.669 to -0.194, PIVW = 3.70E-04), semi-skimmed milk (beta: -0.825, 95% CI: -1.626 to -0.024, PIVW = 4.30E-02), flora and benecol spread (beta: 0.210, 95% CI: 0.037-0.382, PIVW = 1.80E-02), tablespoons of raw vegetables per day (beta: -0.361, 95% CI: -0.563 to -0.158, PIVW = 4.80E-04), no dairy restrictions (beta: 1.223, 95% CI: 0.372-2.074, PIVW = 4.90E-03) and no eggs, dairy, wheat, or sugar restrictions (beta: 1.027, 95% CI: 0.377-1.677, PIVW = 2.00E-03). All significant MR results are false discovery rate-corrected. This MR investigation revealed that various dietary habits were causally linked to low hand grip strength. Further investigations into their relationships are necessary and will contribute to preventing low hand grip strength. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, LLC.)
Competing Interests:	The authors have no conflicts of interest to declare.
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Contributed Indexing:	Keywords: Mendelian randomization; causal relationship; dietary habits; low hand grip strength; reverse Mendelian randomization
Entry Date(s):	Date Created: 20260815 Date Completed: 20260815 Latest Revision: 20260923
Update Code:	20260923
PubMed Central ID:	PMC13480745
DOI:	10.1097/MD.0000000000050178
PMID:	42601712
Βάση Δεδομένων:	MEDLINE

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ISSN:	1536-5964
DOI:	10.1097/MD.0000000000050178