Academic Journal
The changing spectrum of cutaneous leishmaniasis and HIV coinfection in Bolivian Amazonia: a case report.
| Τίτλος: | The changing spectrum of cutaneous leishmaniasis and HIV coinfection in Bolivian Amazonia: a case report. |
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| Συγγραφείς: | Gotor-Rivera A; Department of Dermatology, University Hospital '12 de Octubre', Madrid 28041, Spain., Aparicio-Loayza ML; University of Barcelona, Campus de las Américas, Gran Via de les Corts Catalanes, 585, Barcelona 08007, Spain., Naumionek RFM; Department of Pathology, University Hospital '12 de Octubre', Madrid 28041, Spain., Peralto JLR; Department of Pathology, University Hospital '12 de Octubre', Madrid 28041, Spain.; Faculty of Medicine, Complutense University of Madrid, Pl. de Ramón y Cajal, 28040 Madrid, Spain., Melendres-Moscoso MR; Investigación en Medicine Tropical y Salud Internacional de la Bio Regiones Bioliviana, Riberalta, Bolivia., López-Ochoa Y; Vector Borne Diseases of the Health Network 07, Riberalta, Bolivia.; Universidad Autonoma del Beni, Riberalta, Bolivia. |
| Πηγή: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2026 Sep 02; Vol. 120 (9), pp. 991-994. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| Ιατρικοί όροι (MeSH): | Leishmaniasis, Cutaneous*/drug therapy , Leishmaniasis, Cutaneous*/diagnosis , Leishmaniasis, Cutaneous*/complications , Amphotericin B*/therapeutic use , Antiprotozoal Agents*/therapeutic use , HIV Infections*/complications , HIV Infections*/drug therapy , Coinfection*, Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/therapeutic use ; Bolivia/epidemiology ; Humans ; Male ; Adult ; Treatment Outcome |
| Περίληψη: | Case Report: A 34-year-old man with advanced HIV infection presented with localized cutaneous leishmaniasis, after unsuccessful trestment with pentavalent antimonials, progressive dissemination ocurred . On re-evaluation, he exhibited numerous widespread ulcerated papules and nodules , accompanied by systemic symptoms and significant weight loss. Skin smears and histopathology demonstrated intracellular amastigotes. A diagnosis of intermediate cutaneous leishmaniasis with HIV coinfection was established. Treatment with liposomal amphotericin B followed by oral miltefosine led only to transitory clinical resolution. Discussion: This case highlights the diagnostic and therapeutic challenges of leishmaniasis in immunocompromised patients and underscores the dynamic nature of the clinical classification of cutaneous leishmaniasis. (© The Author(s) 2026. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com.) |
| Contributed Indexing: | Keywords: Leishmania amazonensis; cutaneous leishmaniasis; liposomal amphotericin B; miltefosine; pentavalent antimonial |
| Substance Nomenclature: | 7XU7A7DROE (Amphotericin B) 0 (Antiprotozoal Agents) 107-73-3 (Phosphorylcholine) 53EY29W7EC (miltefosine) 0 (liposomal amphotericin B) |
| Entry Date(s): | Date Created: 20260814 Date Completed: 20260902 Latest Revision: 20260902 |
| Update Code: | 20260902 |
| DOI: | 10.1093/trstmh/trag096 |
| PMID: | 42600141 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-3503 |
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| DOI: | 10.1093/trstmh/trag096 |