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Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.

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Τίτλος: Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.
Συγγραφείς: Han M; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: mubai_lm8@126.com., Li X; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: xtli@xidian.edu.cn.
Πηγή: Public health [Public Health] 2026 Oct; Vol. 259, pp. 106449. Date of Electronic Publication: 2026 Aug 13.
Τύπος έκδοσης: Journal Article; Meta-Analysis; Systematic Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376507 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5616 (Electronic) Linking ISSN: 00333506 NLM ISO Abbreviation: Public Health Subsets: MEDLINE
Imprint Name(s): Publication: 2003- : Amsterdam : Elsevier
Original Publication: London ; New York : Academic Press
Ιατρικοί όροι (MeSH): Exercise*/physiology , Postprandial Period*/physiology , Sedentary Behavior* , Sitting Position*, Blood Glucose/analysis ; Insulin/blood ; Triglycerides/blood ; Adult ; Humans ; Randomized Controlled Trials as Topic ; Time Factors
Περίληψη: Objectives: To evaluate the acute effects of short activity breaks interrupting prolonged sitting on postprandial glucose, triglycerides and insulin in sedentary adults, and to explore dose-response relationships and meal-type differences.
Study Design: Systematic review and meta-analysis of randomised cross-over trials.
Methods: We searched PubMed, Web of Science, Cochrane Library, ProQuest, EBSCO and CNKI up to 9 May 2026. Fifteen studies were included. Postprandial glucose was analysed using a three-level model, insulin with a two-level model, and triglycerides with a conventional random-effects model. Dose-response relationships were examined using three-level meta-regression (MET-min/day). Heterogeneity was partitioned, and sensitivity analyses, publication bias tests and GRADE assessment were performed.
Results: Short activity breaks significantly reduced postprandial glucose (Hedge's g = -0.726, 95% CI -1.167 to -0.285), triglycerides (g = -0.48, 95% CI -0.74 to -0.22) and insulin (g = -0.784, 95% CI -1.144 to -0.425). A linear dose-response relationship was observed for glucose: each 10 MET-min/day increment reduced g by 0.08 (95% CI -0.108 to -0.051). For insulin, no dose-response relationship was found (p = 0.409). No significant meal-type differences were detected (p = 0.317).
Conclusions: Interrupting prolonged sitting with short activity breaks improves postprandial glucose and insulin in sedentary adults, and reduces triglycerides, albeit with a prediction interval that included zero. The glucose benefit follows a linear dose-response pattern and is similar across breakfast, lunch and dinner. No such dose-response relationship was observed for insulin.
(Copyright © 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest None.
Contributed Indexing: Keywords: Meta-analysis; Physical activity; Postprandial metabolism; Sedentary behaviour; Short activity breaks
Substance Nomenclature: 0 (Blood Glucose)
0 (Insulin)
0 (Triglycerides)
Entry Date(s): Date Created: 20260813 Date Completed: 20261007 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1016/j.puhe.2026.106449
PMID: 42594545
Βάση Δεδομένων: MEDLINE
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  Data: Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Han+M%22">Han M</searchLink>; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: mubai_lm8@126.com.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: xtli@xidian.edu.cn.
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  Data: Objectives: To evaluate the acute effects of short activity breaks interrupting prolonged sitting on postprandial glucose, triglycerides and insulin in sedentary adults, and to explore dose-response relationships and meal-type differences.<br />Study Design: Systematic review and meta-analysis of randomised cross-over trials.<br />Methods: We searched PubMed, Web of Science, Cochrane Library, ProQuest, EBSCO and CNKI up to 9 May 2026. Fifteen studies were included. Postprandial glucose was analysed using a three-level model, insulin with a two-level model, and triglycerides with a conventional random-effects model. Dose-response relationships were examined using three-level meta-regression (MET-min/day). Heterogeneity was partitioned, and sensitivity analyses, publication bias tests and GRADE assessment were performed.<br />Results: Short activity breaks significantly reduced postprandial glucose (Hedge's g = -0.726, 95% CI -1.167 to -0.285), triglycerides (g = -0.48, 95% CI -0.74 to -0.22) and insulin (g = -0.784, 95% CI -1.144 to -0.425). A linear dose-response relationship was observed for glucose: each 10 MET-min/day increment reduced g by 0.08 (95% CI -0.108 to -0.051). For insulin, no dose-response relationship was found (p = 0.409). No significant meal-type differences were detected (p = 0.317).<br />Conclusions: Interrupting prolonged sitting with short activity breaks improves postprandial glucose and insulin in sedentary adults, and reduces triglycerides, albeit with a prediction interval that included zero. The glucose benefit follows a linear dose-response pattern and is similar across breakfast, lunch and dinner. No such dose-response relationship was observed for insulin.<br /> (Copyright © 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.)
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  Data: Declaration of competing interest None.
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