Academic Journal
Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.
| Τίτλος: | Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis. |
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| Συγγραφείς: | Han M; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: mubai_lm8@126.com., Li X; Institute of Environmental Physiology and Conditioning, Xidian University, Xi'an, Shaanxi, 710126, China. Electronic address: xtli@xidian.edu.cn. |
| Πηγή: | Public health [Public Health] 2026 Oct; Vol. 259, pp. 106449. Date of Electronic Publication: 2026 Aug 13. |
| Τύπος έκδοσης: | Journal Article; Meta-Analysis; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376507 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5616 (Electronic) Linking ISSN: 00333506 NLM ISO Abbreviation: Public Health Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Amsterdam : Elsevier Original Publication: London ; New York : Academic Press |
| Ιατρικοί όροι (MeSH): | Exercise*/physiology , Postprandial Period*/physiology , Sedentary Behavior* , Sitting Position*, Blood Glucose/analysis ; Insulin/blood ; Triglycerides/blood ; Adult ; Humans ; Randomized Controlled Trials as Topic ; Time Factors |
| Περίληψη: | Objectives: To evaluate the acute effects of short activity breaks interrupting prolonged sitting on postprandial glucose, triglycerides and insulin in sedentary adults, and to explore dose-response relationships and meal-type differences. Study Design: Systematic review and meta-analysis of randomised cross-over trials. Methods: We searched PubMed, Web of Science, Cochrane Library, ProQuest, EBSCO and CNKI up to 9 May 2026. Fifteen studies were included. Postprandial glucose was analysed using a three-level model, insulin with a two-level model, and triglycerides with a conventional random-effects model. Dose-response relationships were examined using three-level meta-regression (MET-min/day). Heterogeneity was partitioned, and sensitivity analyses, publication bias tests and GRADE assessment were performed. Results: Short activity breaks significantly reduced postprandial glucose (Hedge's g = -0.726, 95% CI -1.167 to -0.285), triglycerides (g = -0.48, 95% CI -0.74 to -0.22) and insulin (g = -0.784, 95% CI -1.144 to -0.425). A linear dose-response relationship was observed for glucose: each 10 MET-min/day increment reduced g by 0.08 (95% CI -0.108 to -0.051). For insulin, no dose-response relationship was found (p = 0.409). No significant meal-type differences were detected (p = 0.317). Conclusions: Interrupting prolonged sitting with short activity breaks improves postprandial glucose and insulin in sedentary adults, and reduces triglycerides, albeit with a prediction interval that included zero. The glucose benefit follows a linear dose-response pattern and is similar across breakfast, lunch and dinner. No such dose-response relationship was observed for insulin. (Copyright © 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest None. |
| Contributed Indexing: | Keywords: Meta-analysis; Physical activity; Postprandial metabolism; Sedentary behaviour; Short activity breaks |
| Substance Nomenclature: | 0 (Blood Glucose) 0 (Insulin) 0 (Triglycerides) |
| Entry Date(s): | Date Created: 20260813 Date Completed: 20261007 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1016/j.puhe.2026.106449 |
| PMID: | 42594545 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1476-5616 |
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| DOI: | 10.1016/j.puhe.2026.106449 |