Academic Journal
Effects of a prebiotic fibre-enriched bread in older adults: a randomised, placebo-controlled, parallel-groups feasibility study (BiomeBakery).
| Τίτλος: | Effects of a prebiotic fibre-enriched bread in older adults: a randomised, placebo-controlled, parallel-groups feasibility study (BiomeBakery). |
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| Συγγραφείς: | Lee Y; School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Colombage RL; School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Hall CV; Myota Limited, London, United Kingdom., Lamport DJ; School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Williams CM; School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Hepsomali P; School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom. Electronic address: p.hepsomali@reading.ac.uk. |
| Πηγή: | The journal of nutrition, health & aging [J Nutr Health Aging] 2026 Oct; Vol. 30 (10), pp. 100939. Date of Electronic Publication: 2026 Aug 13. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co. |
| Ιατρικοί όροι (MeSH): | Prebiotics*/administration & dosage , Dietary Fiber*/administration & dosage , Bread* , Food, Fortified*, Cognition/drug effects ; Affect/drug effects ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Memory/drug effects ; Humans ; Aged ; Female ; Double-Blind Method ; Male ; Aged, 80 and over ; Middle Aged ; Feasibility Studies |
| Περίληψη: | Objectives: To examine the feasibility and effects of consuming an additional 10 g/day of prebiotic fibre blend in a bread roll on cognitive, mood, gastrointestinal outcomes, and peripheral biomarkers in older adults without dementia and with low habitual dietary fibre intake. Design: A single-centre, randomised, double-blind, placebo-controlled parallel groups design (Registration at clinicaltrials.gov; NCT06796712). Setting and Participants: Fifty-three community-dwelling adults aged 60-80 years without dementia and with low habitual dietary fibre intake. Intervention: Participants were assigned to either a treatment (fibre-enriched white bread roll) group (n = 28) or a placebo (matched white bread roll) group (n = 25) and consumed their assigned products for 12 weeks. Measurements: Cognitive, mood, gastrointestinal outcomes, as well as C-reactive protein, lipids, and glucose levels were assessed at the baseline and after 12-weeks. Results: Placebo consumption for 12 weeks was associated with improvements in memory compared with treatment. However, the treatment group showed a decrease in hostility after 12 weeks, whereas the placebo group showed an increase. The placebo group also demonstrated an increase in HDL cholesterol, while the treatment group showed a decrease. No significant differences were observed for the other outcomes. Conclusion: Fibre-enriched bread may have selective effects on aspects of mood (e.g., hostility) in ageing populations, although most mood, cognitive, and biological outcomes were unchanged. The observed improvement on mood occurred independently of inflammatory or cardiovascular changes, suggesting potential involvement of the gut-brain axis and the need for additional mechanistic endpoints to clarify the underlying mechanistic pathways. Cognitive and inflammatory changes may require longer interventions, different dosing or populations, highlighting the need for further investigation in larger and more diverse samples. (Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest C. V. H. is an employee/shareholder of Myota Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; or in the decision to publish the results. |
| Contributed Indexing: | Keywords: Anxiety; Cognition; Depression; Inflammation; Mood; Prebiotics |
| Molecular Sequence: | ClinicalTrials.gov NCT06796712 |
| Substance Nomenclature: | 0 (Prebiotics) 0 (Dietary Fiber) 0 (Biomarkers) 9007-41-4 (C-Reactive Protein) |
| Entry Date(s): | Date Created: 20260813 Date Completed: 20261003 Latest Revision: 20261006 |
| Update Code: | 20261006 |
| PubMed Central ID: | PMC13495385 |
| DOI: | 10.1016/j.jnha.2026.100939 |
| PMID: | 42594505 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1760-4788 |
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| DOI: | 10.1016/j.jnha.2026.100939 |