Academic Journal
Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.
| Τίτλος: | Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development. |
|---|---|
| Συγγραφείς: | Li Y; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Lai R; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., He Y; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Cheng K; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Cheng L; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Yi J; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Li Y; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Zhou S; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. |
| Πηγή: | Cells [Cells] 2026 Aug 01; Vol. 15 (15). Date of Electronic Publication: 2026 Aug 01. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Ιατρικοί όροι (MeSH): | Organoids*/growth & development , Intestines*/pathology , Intestines*/cytology , Stem Cells*/cytology , Stem Cells*/metabolism , Intestinal Diseases*/pathology , Stem Cell Research*, Humans ; Animals ; Signal Transduction ; Stem Cell Niche |
| Περίληψη: | Intestinal stem cells (ISCs) are essential for maintaining intestinal homeostasis and repairing injury, and have garnered extensive attention in recent years. ISC research has not only advanced our understanding of intestinal physiology but also revealed pathological roles of ISCs in diseases and facilitated the identification of potential targeted therapies. This review aims to comprehensively present the current state of ISC research. It elaborates on the multi-level regulatory mechanisms governing ISCs, including niche cells, signaling pathways, gut microbiota, extracellular matrix, and epigenetic regulation. It further summarizes the involvement of ISCs in colorectal cancer, inflammatory bowel disease, radiation-induced intestinal injury, and short bowel syndrome, as well as their application in organoid technology. Finally, this review highlights future directions, including dissecting how distinct cellular states and microenvironments dynamically regulate ISC function, and the integration of cutting-edge technologies like microfluidic organ-on-a-chip and gene editing technologies to accelerate the translation of basic discoveries into clinical practice, thereby providing a valuable reference for researchers in the field. |
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| Grant Information: | 82374591 National Natural Science Foundation of China; 24NSFC7495 the Sichuan Natural Science Foundation Youth Foundation Project |
| Contributed Indexing: | Keywords: colorectal cancer; inflammatory bowel disease; intestinal organoid; intestinal stem cell; regulatory mechanisms; research development |
| Entry Date(s): | Date Created: 20260813 Date Completed: 20260813 Latest Revision: 20260815 |
| Update Code: | 20260815 |
| PubMed Central ID: | PMC13463884 |
| DOI: | 10.3390/cells15151396 |
| PMID: | 42587804 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2073-4409 |
|---|---|
| DOI: | 10.3390/cells15151396 |