Academic Journal
Ivermectin impairs memory retrieval performance by B6 nestin-cre mice.
| Τίτλος: | Ivermectin impairs memory retrieval performance by B6 nestin-cre mice. |
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| Συγγραφείς: | Schoderboeck L; Department of Biochemistry, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Department of Psychology, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand., Ohline SM; Department of Psychology, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Department of Physiology, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand., van der Salm L; Department of Psychology, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand., Wicky HE; Department of Biochemistry, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 54, Dunedin 9054, New Zealand., Hughes SM; Department of Biochemistry, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 54, Dunedin 9054, New Zealand. Electronic address: stephanie.hughes@otago.ac.nz., Abraham WC; Department of Psychology, University of Otago, PO Box 54, Dunedin 9054, New Zealand; Brain Health Research Centre, University of Otago, PO Box 54, Dunedin 9054, New Zealand. Electronic address: cliff.abraham@otago.ac.nz. |
| Πηγή: | Neurobiology of learning and memory [Neurobiol Learn Mem] 2026 Sep; Vol. 227, pp. 108206. Date of Electronic Publication: 2026 Aug 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 9508166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9564 (Electronic) Linking ISSN: 10747427 NLM ISO Abbreviation: Neurobiol Learn Mem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Diego, Calif. : Academic Press, c1995- |
| Ιατρικοί όροι (MeSH): | Ivermectin*/pharmacology , Ivermectin*/administration & dosage , Hippocampus*/drug effects , Mental Recall*/drug effects , Mental Recall*/physiology , Spatial Memory*/drug effects, Fear/drug effects ; Nestin/genetics ; Neurogenesis/drug effects ; Neurons/drug effects ; Neurons/physiology ; Conditioning, Classical/drug effects ; Maze Learning/drug effects ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic |
| Περίληψη: | The role of adult-born neurons in the hippocampal dentate gyrus and its significance in memory processes is a field of high interest. To add to this literature, we investigated the feasibility of ivermectin-based chemogenetic manipulation of recently born neurons in the hippocampus in altering spatial and contextual memory retrieval. The adult-born neurons in male mice were targeted using a nestin-cre mouse model, employing lentivirus-mediated transduction of inhibitory chloride channel constructs sensitive or insensitive to ivermectin in order to be able to silence them during different developmental stages. Two mouse age groups were compared: 5 weeks and 5 months old at the time of lentivirus injection. Behavioural assessments involving the Morris water maze and contextual fear conditioning were conducted. Unexpectedly, ivermectin administration alone led to apparent memory impairments regardless of the virus construct, confounding behavioural test outcomes. This study highlights the challenge of distinguishing specific effects of targeting adult-born neuronal activity from nonspecific effects of ivermectin on cognition. (Copyright © 2026. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Chloride channel; Fear conditioning; Hippocampus; Ivermectin; Neurogenesis; Spatial memory |
| Substance Nomenclature: | 70288-86-7 (Ivermectin) 0 (Nestin) |
| Entry Date(s): | Date Created: 20260812 Date Completed: 20260909 Latest Revision: 20260909 |
| Update Code: | 20260910 |
| DOI: | 10.1016/j.nlm.2026.108206 |
| PMID: | 42586306 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1095-9564 |
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| DOI: | 10.1016/j.nlm.2026.108206 |