Academic Journal
Non-linear association of induction dose with early dropout from methadone maintenance treatment: A retrospective cohort study.
| Τίτλος: | Non-linear association of induction dose with early dropout from methadone maintenance treatment: A retrospective cohort study. |
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| Συγγραφείς: | Wang H; Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China., Xiong W; Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China., Tang X; Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Social Psychiatry, the Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China., Wang C; Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China., Li B; Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China., Ling L; Department of Medical Statistics, Sun Yat-sen University, Guangzhou, Guangdong, China; Clinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: lingli@mail.sysu.edu.cn. |
| Πηγή: | Drug and alcohol dependence [Drug Alcohol Depend] 2026 Oct 01; Vol. 287, pp. 113300. Date of Electronic Publication: 2026 Aug 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Original Publication: Lausanne, Elsevier Sequoia. |
| Ιατρικοί όροι (MeSH): | Methadone*/administration & dosage , Methadone*/therapeutic use , Opiate Substitution Treatment*/methods , Patient Dropouts*/statistics & numerical data , Opioid-Related Disorders*/drug therapy, Humans ; Retrospective Studies ; Dose-Response Relationship, Drug ; Female ; Male ; Adult ; Cohort Studies ; Middle Aged |
| Περίληψη: | Background: Conservative induction dose in methadone maintenance treatment (MMT) may lead to early dropout. Existing evidence mostly focuses on linear associations, leaving non-linear dose-response relationships and critical inflection points unexplored. Methods: This retrospective cohort study analyzed 5083 first-time patients across 11 MMT clinics in Guangdong Province (2006-2021). The mean methadone dose in the first week defined the induction dose, and dropout within 30 days was the outcome. Restricted Cubic Spline (RCS) and threshold analysis explored non-linear and inflection points. Results: After confounder adjustment, a significant negative association existed between dose and dropout (OR=0.900, 95% CI: 0.876-0.924), confirmed with weighting. A non-linear relationship was identified (P Conclusion: The study identified a non-linear association between induction dose and early dropout, and there is a threshold effect inflection point. Based on current guidelines, there is a need to appropriately increase the starting dose of MMT, with further consideration of methadone safety and individual differences required in clinical practice. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: China; Early dropout; Induction dose; Methadone maintenance treatment; Non-linear association; Threshold effect |
| Substance Nomenclature: | UC6VBE7V1Z (Methadone) |
| Entry Date(s): | Date Created: 20260812 Date Completed: 20260909 Latest Revision: 20260909 |
| Update Code: | 20260910 |
| DOI: | 10.1016/j.drugalcdep.2026.113300 |
| PMID: | 42585946 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0046 |
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| DOI: | 10.1016/j.drugalcdep.2026.113300 |