Academic Journal
Predicting of Nano Cerium/Hydroxyapatite Efficiency Against γ- Irradiation Induced Heart Failure in Albino Rats.
| Τίτλος: | Predicting of Nano Cerium/Hydroxyapatite Efficiency Against γ- Irradiation Induced Heart Failure in Albino Rats. |
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| Συγγραφείς: | El-Sherbiny EM; Radioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt., Abdelrahman MT; Radioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt. mohamadt.abdelrahman@gmail.com., Gheriany EI; Radioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt. |
| Πηγή: | Cell biochemistry and biophysics [Cell Biochem Biophys] 2026 Sep; Vol. 84 (3), pp. 4015-4024. Date of Electronic Publication: 2026 Aug 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Totowa, NJ : Humana Press, c1996- |
| Ιατρικοί όροι (MeSH): | Cerium*/chemistry , Cerium*/therapeutic use , Cerium*/pharmacology , Gamma Rays*/adverse effects , Heart Failure*/etiology , Heart Failure*/drug therapy , Heart Failure*/pathology , Heart Failure*/metabolism , Durapatite*/chemistry , Durapatite*/therapeutic use , Nanocomposites*/chemistry , Nanocomposites*/therapeutic use, Myocardium/pathology ; Myocardium/metabolism ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Troponin I/blood ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/metabolism ; Creatine Kinase/blood ; L-Lactate Dehydrogenase/blood ; C-Reactive Protein/metabolism ; Interleukin-6/blood ; Heart/drug effects ; Heart/radiation effects ; Animals ; Male ; Rats |
| Περίληψη: | The study was conducted to investigate the therapeutic potential of nano cerium hydroxyapatite (nCe/HAp) on γ-irradiation (IR) induced cardiac failure in male rats. Cardiac failure was induced by exposure to 9 Gy of γ-radiation. The nanocomposite nCe/HAp was administered at a dose of 50 mg/kg b.w. intravenously. The levels of oxidative status, heart enzymes, troponin I (cTnI), total creatine kinase (CK), creatine phosphokinase isoenzyme (CK-MB), and lactate dehydrogenase (LDH) were measured, in addition to immune status, by measuring the levels of nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP). Pathological analysis of heart tissue was undertaken for all animals. The results revealed the effectiveness of nCe/HAp in ameliorating most of the examined parameters by significantly elevating the GSH and SOD activity levels. On the other side, there was a significant decline in the serum NO, MDA, cTnI, NF-kB, CK, CK-MB and LDH levels upon treatment. Microscopic evaluation of tissue samples confirmed the biochemical outcomes and the variance between the control and the other treated groups. In conclusion, nCe/HAp succeeded in preventing heart damage to a considerable degree, and paves the way for Ce/HAp nanocomposites as promising effective candidates for mitigating radiation treatments. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Animal Ethics declaration: The current research was conducted in compliance with the ARRIVE guidelines 2.0 and EU Directive 2010/63/EU for animal experiments. Consent to Participate: This study uses albino rats as experimental subjects, not human participants. Consent to Publish: This article features albino rats as the experimental animals, not humans. The authors are accountable for the accuracy of all statements presented in the manuscript. Conflict of Interests: The authors affirm that there are no conflicts of interest associated with this work. |
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| Contributed Indexing: | Keywords: Heart Failure; Nanocomposite nCe/HAp; Rat model; γ- Irradiation |
| Substance Nomenclature: | 30K4522N6T (Cerium) 91D9GV0Z28 (Durapatite) 0 (Troponin I) 0 (NF-kappa B) 0 (Tumor Necrosis Factor-alpha) EC 2.7.3.2 (Creatine Kinase) EC 1.1.1.27 (L-Lactate Dehydrogenase) 9007-41-4 (C-Reactive Protein) 0 (Interleukin-6) |
| Entry Date(s): | Date Created: 20260811 Date Completed: 20260917 Latest Revision: 20260917 |
| Update Code: | 20260918 |
| DOI: | 10.1007/s12013-026-02101-4 |
| PMID: | 42579042 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1559-0283 |
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| DOI: | 10.1007/s12013-026-02101-4 |