Academic Journal
A γ-Ray-Responsive Dynamic Covalent Polymeric Radioprotectant for Efficient Radiation Injury Treatment.
| Title: | A γ-Ray-Responsive Dynamic Covalent Polymeric Radioprotectant for Efficient Radiation Injury Treatment. |
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| Authors: | Ning Y; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Hou X; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Lyu C; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Zhang J; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Chen X; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Ma Q; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Wu Y; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Su L; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Liu J; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Huang F; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. |
| Source: | Advanced healthcare materials [Adv Healthc Mater] 2026 Sep; Vol. 15 (34), pp. e71561. Date of Electronic Publication: 2026 Aug 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim : Wiley-VCH, 2012- |
| MeSH Terms: | Radiation-Protective Agents*/chemistry , Radiation-Protective Agents*/pharmacology , Polymers*/chemistry , Radiation Injuries*/drug therapy , Gamma Rays*, Boronic Acids/chemistry ; Catechin/analogs & derivatives ; Catechin/chemistry ; Catechin/pharmacology ; Reactive Oxygen Species/metabolism ; Curcumin/chemistry ; Curcumin/pharmacology ; Apoptosis/drug effects ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Animals ; Micelles ; Humans ; Mice |
| Abstract: | The increasing risk of radiation exposure has intensified the demand for advanced radioprotective strategies to counteract radiation injury. Here, a γ-ray-responsive dynamic covalent polymeric radioprotectant, engineered by integrating phenylboronic acid (PBA)-functionalized polymeric micelles with the potent antioxidants epigallocatechin-3-gallate (EGCG) and curcumin (Cur), is developed to provide efficient systemic protection. The architecture of this dynamic covalent polymeric radioprotectant is stabilized by reversible dynamic covalent linkages between the PBA moieties and the catechol groups of EGCG, ensuring robust persistence during systemic circulation and precise release within the radiation-triggered microenvironment. Furthermore, the structural affinity between EGCG and Cur facilitates efficient π-π stacking interactions, enabling the synchronized encapsulation and triggered release of the dual-drug cargo. Compared to individual antioxidant treatments, this dynamic covalent system exhibits superior efficacy in scavenging reactive oxygen species (ROS), promoting cell proliferation, and inhibiting apoptosis. In vivo assessments further confirm that this radioprotectant affords comprehensive systemic protection, effectively mitigating radiation-related physiological damage and enhancing overall survival by orchestrating endogenous antioxidant responses. Given that numerous molecules with radioprotective potential possess diol or catechol motifs, this modular and responsive design offers a versatile framework for on-demand radioprotection, greatly promising for clinical translation. (© 2026 Wiley‐VCH GmbH.) |
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| Grant Information: | 52473162 National Natural Science Foundation of China; 22205262 National Natural Science Foundation of China; 23JCZDJC00160 Natural Science Foundation of Tianjin, China; JYY25QZZZ0002 State Key Laboratory of Advanced Medical Materials and Devices Research |
| Contributed Indexing: | Keywords: drug delivery; dynamic covalent; polymeric micelle; radioprotection; ray‐responsive |
| Substance Nomenclature: | 0 (Radiation-Protective Agents) 0 (Polymers) 0 (Boronic Acids) 8R1V1STN48 (Catechin) 0 (Micelles) 0 (Reactive Oxygen Species) BQM438CTEL (epigallocatechin gallate) IT942ZTH98 (Curcumin) L12H7B02G5 (benzeneboronic acid) 0 (Antioxidants) |
| Entry Date(s): | Date Created: 20260811 Date Completed: 20260911 Latest Revision: 20260913 |
| Update Code: | 20260913 |
| PubMed Central ID: | PMC13568956 |
| DOI: | 10.1002/adhm.71561 |
| PMID: | 42576406 |
| Database: | MEDLINE |
| ISSN: | 2192-2659 |
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| DOI: | 10.1002/adhm.71561 |