Academic Journal
Modulatory role of the mPFC orexin-2 receptors in the acquisition and expression in two paradigms of the natural- and drug-induced conditioned place preference in the rats.
| Τίτλος: | Modulatory role of the mPFC orexin-2 receptors in the acquisition and expression in two paradigms of the natural- and drug-induced conditioned place preference in the rats. |
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| Συγγραφείς: | Jamali S; Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mirmohammadi M; Neurobiology Research Center Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Azizbeigi R; Department of Basic Sciences, Sa.C., Islamic Azad University, Sanandaj, Iran., Alizamini MM; Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Taslimi Z; Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran., Haghparast A; Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran; Department of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran; National Brain Mapping Laboratory (NBML), Tehran, Iran. Electronic address: Haghparast@yahoo.com. |
| Πηγή: | Behavioural brain research [Behav Brain Res] 2026 Oct 18; Vol. 515, pp. 116430. Date of Electronic Publication: 2026 Aug 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Orexin Receptors*/metabolism , Orexin Receptors*/physiology , Orexin Receptors*/drug effects , Prefrontal Cortex*/drug effects , Prefrontal Cortex*/metabolism , Prefrontal Cortex*/physiology , Drug-Seeking Behavior*/drug effects , Drug-Seeking Behavior*/physiology , Behavior, Animal*/drug effects , Behavior, Animal*/physiology, Orexin Receptor Antagonists/pharmacology ; Orexin Receptor Antagonists/administration & dosage ; Morphine/pharmacology ; Morphine/administration & dosage ; Isoquinolines/pharmacology ; Benzoxazoles/pharmacology ; Animals ; Male ; Rats, Wistar ; Reward ; Rats ; Naphthyridines ; Pyridines |
| Περίληψη: | The neuropeptide orexin/hypocretin regulates adaptive behaviors needed for survival, including food intake, sleep-wake regulation, mating, and maternal behavior. However, the orexinergic system plays a critical role in addictive behavior and promotes seeking and rewarding substances of abuse and palatable food. Plenty of orexin receptors exist in the medial prefrontal cortex (mPFC). The PFC input to the NAc mediates goal-directed behaviors such as seeking behavior and planning actions to obtain rewarding substances. This study investigated the role of mPFC orexin-2 receptors (Orx2Rs) in natural-and drug-reward-seeking behaviors. One hundred sixteen adult male Wistar rats received TCS OX2 29 (3, 10, and 30 nmol/0.5 µl DMSO 12%) as an Orx2R antagonist in the mPFC during the acquisition and expression phases of two different CPP paradigms, morphine- and food-induced CPP protocols. Findings demonstrated that intra-mPFC administration of Orx2R antagonist reduced the acquisition and expression of morphine- and food-induced CPP in the rats. However, blockades of Orx2Rs in the mPFC have more inhibitory effects in food-induced CPP than in morphine-induced CPP. In conclusion, this study proposes a differential involvement of mPFC Orx2Rs in the acquisition and expression phases of CPP, suggesting distinguishable behavioral effects between food and morphine reward models. However, further mechanistic studies are required to clarify the underlying neural substrates. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they do not have any conflict of interest. |
| Contributed Indexing: | Keywords: Conditioned place preference; Drug reward; Food; Medial prefrontal cortex; Morphine; Natural reward; Orexin-2 receptor; Rat |
| Substance Nomenclature: | 0 (Orexin Receptors) 0 (Orexin Receptor Antagonists) 76I7G6D29C (Morphine) 0 (Isoquinolines) 0 (1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone) 0 (Hcrtr2 protein, rat) 0 (Benzoxazoles) 0 (Naphthyridines) 0 (Pyridines) |
| Entry Date(s): | Date Created: 20260810 Date Completed: 20260904 Latest Revision: 20260904 |
| Update Code: | 20260905 |
| DOI: | 10.1016/j.bbr.2026.116430 |
| PMID: | 42575364 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-7549 |
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| DOI: | 10.1016/j.bbr.2026.116430 |