Academic Journal
Effect of lung volume on the apnea hypopnea index in patients with overlap syndrome: a single center study.
| Τίτλος: | Effect of lung volume on the apnea hypopnea index in patients with overlap syndrome: a single center study. |
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| Συγγραφείς: | Zhu J; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China., Wu X; Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Hu Y; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yang X; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; School of Medicine, Jianghan University, Wuhan, China., Liu X; Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China., Xiong M; Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China., Hu K; Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China. huke-rmhospital@163.com. |
| Πηγή: | Sleep & breathing = Schlaf & Atmung [Sleep Breath] 2026 Aug 10; Vol. 30 (4). Date of Electronic Publication: 2026 Aug 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 9804161 Publication Model: Electronic Cited Medium: Internet ISSN: 1522-1709 (Electronic) Linking ISSN: 15209512 NLM ISO Abbreviation: Sleep Breath Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : Heidelberg ; New York : Springer Original Publication: Titisee-Neustadt, Germany : Druckbild GmbH |
| Ιατρικοί όροι (MeSH): | Sleep Apnea, Obstructive*/physiopathology , Sleep Apnea, Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/physiopathology , Pulmonary Disease, Chronic Obstructive*/diagnosis , Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome*/physiopathology , Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome*/diagnosis , Tidal Volume*/physiology , Lung Volume Measurements*, Humans ; Female ; Polysomnography ; Male ; Middle Aged ; Aged ; Spirometry ; Statistics as Topic |
| Περίληψη: | Purpose: This study aimed to evaluate the relationship between lung volume and apnea-hypopnea index (AHI) in patients with overlap syndrome (OVS). Methods: Chronic obstructive pulmonary disease (COPD) patients diagnosed by spirometry were recruited from Renmin Hospital of Wuhan University. They were asked to take an overnight polysomnography (PSG). Multiple regression analyses were used to assess the relationships between lung volume measures and AHI in OVS patients. Results: Finally, 354 OVS patients and 229 patients with only COPD met the study's entry criteria. After adjusting for age, sex, BMI, neck size, economic status, smoking, alcohol use, and hypertension, residual volume (RV), total lung capacity (TLC), and the RV/TLC ratio each had a negative link with the AHI in OVS patients (RV: exp(β) = 0.903; 95% CI, 0.852 to 0.957; P < 0.05; TLC: exp(β) = 0.947; 95% CI, 0.899 to 0.998; P < 0.05; RV/TLC: exp(β) = 0.898; 95% CI, 0.846 to 0.954; P < 0.01). However, when RV was added as a covariate in the model, forced expiratory volume in one second (FEV Conclusion: The higher residual volume was independently associated with lower AHI in patients with overlap syndrome, particularly among patients with GOLD 3-4 airflow limitation. (© 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Competing Interests: | Declarations. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of Renmin Hospital of Wuhan University and with the 1964 Helsinki declaration and its later amendments. Informed consent: Informed consent was obtained from all individual participants included in the study. Conflict of interest: The authors declare that they have no conflict of interest. |
| References: | Sleep Breath. 2020 Sep;24(3):1059-1066. (PMID: 31768930) Thorax. 2017 Mar;72(3):256-262. (PMID: 27807016) Sleep. 2003 Nov 1;26(7):851-6. (PMID: 14655919) Lung. 2017 Feb;195(1):127-133. (PMID: 27770204) Einstein (Sao Paulo). 2014 Jan-Mar;12(1):120-5. (PMID: 24728258) Ann Am Thorac Soc. 2015 Aug;12(8):1219-25. (PMID: 25871443) J Appl Physiol (1985). 2015 Aug 1;119(3):266-71. (PMID: 26048975) Curr Vasc Pharmacol. 2021;19(3):285-300. (PMID: 32188387) Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):522-7. (PMID: 9279234) Sleep Breath. 2009 Nov;13(4):317-23. (PMID: 19484281) Int J Clin Pract. 2007 Feb;61(2):207-11. (PMID: 17263708) Sleep Breath. 2020 Mar;24(1):119-125. (PMID: 31055726) BMC Pulm Med. 2015 Jul 25;15:76. (PMID: 26209328) Sleep Med Rev. 2017 Apr;32:58-68. (PMID: 28169105) Nepal Med Coll J. 2005 Jun;7(1):32-5. (PMID: 16295718) Am J Respir Crit Care Med. 2016 Oct 15;194(8):1007-1014. (PMID: 27105053) Thorax. 2006 May;61(5):435-9. (PMID: 16490766) J Appl Physiol (1985). 1988 Nov;65(5):2124-31. (PMID: 3209556) |
| Grant Information: | 62073149 National Natural Science Foundation of China; WX23A81 The Funding for Scientific Research Projects from Wuhan Municipal Health Commission |
| Contributed Indexing: | Keywords: Apnea-hypopnea index; Chronic obstructive pulmonary disease; Lung volume; Obstructive sleep apnea; Overlap syndrome |
| Entry Date(s): | Date Created: 20260809 Date Completed: 20260810 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s11325-026-03776-y |
| PMID: | 42572058 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1522-1709 |
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| DOI: | 10.1007/s11325-026-03776-y |