Academic Journal
Long-term glycemic outcomes at 24 months after switching from FreeStyle Libre to FreeStyle Libre 2: A real-world study.
| Τίτλος: | Long-term glycemic outcomes at 24 months after switching from FreeStyle Libre to FreeStyle Libre 2: A real-world study. |
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| Συγγραφείς: | Gutiérrez-Pastor A; Department of Health of San Juan de Alicante, Provincial-Pla Hospital, Spain; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain. Electronic address: aaron.gutierrezp@umh.es., Pomares-Gómez FJ; Department of Health of San Juan de Alicante, Endocrinology and Nutrition, Spain., Quesada JA; Department of Clinical Medicine, Miguel Hernández University, Elche, Spain. |
| Πηγή: | Primary care diabetes [Prim Care Diabetes] 2026 Oct; Vol. 20 (5), pp. 582-588. Date of Electronic Publication: 2026 Aug 07. |
| Τύπος έκδοσης: | Journal Article; Observational Study; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 101463825 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0210 (Electronic) Linking ISSN: 18780210 NLM ISO Abbreviation: Prim Care Diabetes Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kidlington, Oxford : Elsevier |
| Ιατρικοί όροι (MeSH): | Diabetes Mellitus, Type 1*/blood , Diabetes Mellitus, Type 1*/drug therapy , Diabetes Mellitus, Type 1*/diagnosis , Blood Glucose*/metabolism , Blood Glucose*/drug effects , Continuous Glucose Monitoring*/instrumentation , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/therapeutic use , Insulin*/administration & dosage , Insulin*/adverse effects , Glycemic Control*/instrumentation , Glycemic Control*/adverse effects , Blood Glucose Self-Monitoring*/instrumentation, Biomarkers/blood ; Glycated Hemoglobin/metabolism ; Humans ; Time Factors ; Female ; Male ; Treatment Outcome ; Adult ; Longitudinal Studies ; Middle Aged ; Equipment Design ; Predictive Value of Tests |
| Περίληψη: | The aim of this study was to evaluate the long-term effectiveness of the FreeStyle Libre 2 device in reducing time below range levels 1 (TBR-1) and 2 (TBR-2), compared with the first-generation FreeStyle Libre device without alarms, in people with type 1 diabetes mellitus. A longitudinal observational pre-post study of a single cohort was conducted in a cohort of 93 people with type 1 diabetes mellitus who switched from FreeStyle Libre to FreeStyle Libre 2 in routine clinical practice. At 24 months post-switch, significant improvements were observed in TBR-1 (p = 0.001) and TBR-2 (p < 0.001). A significant direct association was identified between years with diabetes mellitus and change in total basal insulin dose from T0 to T1, with a coefficient of 0.14. Additionally, a significant inverse association was found between annual income and coefficient of variation, with a coefficient of -6.3, as well as between annual income and TBR-2, with a coefficient of -2.45. Switching to a flash glucose monitoring system with alarms was associated with improvements at 24 months in time below range, coefficient of variation, and HbA1c in individuals with type 1 diabetes mellitus. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Quesada Rico, JA reports financial support was provided by Spain Ministry of Science and Innovation. |
| Contributed Indexing: | Keywords: Continuous glucose monitoring; Glycaemic control; Real-world evidence; Type 1 diabetes |
| Substance Nomenclature: | 0 (Blood Glucose) 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Biomarkers) 0 (hemoglobin A1c protein, human) 0 (Glycated Hemoglobin) |
| Entry Date(s): | Date Created: 20260807 Date Completed: 20260907 Latest Revision: 20261015 |
| Update Code: | 20261015 |
| DOI: | 10.1016/j.pcd.2026.07.014 |
| PMID: | 42567743 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-0210 |
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| DOI: | 10.1016/j.pcd.2026.07.014 |