Academic Journal
Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study.
| Title: | Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study. |
|---|---|
| Authors: | De Vita F; Department of Experimental Medicine, Sapienza University of Rome, Italy. Electronic address: francescodv1998@libero.it., Zampetti S; Department of Experimental Medicine, Sapienza University of Rome, Italy. Electronic address: simona.zampetti@libero.it., Latino A; Department of Experimental Medicine, Sapienza University of Rome, Italy. Electronic address: alessandrolatino@libero.it., Pieralice S; Unit of Endocrinology and Metabolic Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Electronic address: s.pieralice@policlinicocampus.it., Lauria Pantano A; Diabetes Unit, San Camillo- Forlanini Hospital, Rome, Italy. Electronic address: ALauriaPantano@scamilloforlanini.rm.it., Tubili C; Diabetes Unit, San Camillo- Forlanini Hospital, Rome, Italy. Electronic address: claudiotubili7@gmail.com., D'Onofrio L; Diabetes Unit, Policlinico Umberto I University Hospital, Rome, Italy. Electronic address: luca.donofrio@uniroma1.it., Coraggio L; Diabetes Unit, Policlinico Umberto I University Hospital, Rome, Italy. Electronic address: l.coraggio@policlinicoumberto1.it., Napoli N; Unit of Endocrinology and Metabolic Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Electronic address: N.Napoli@policlinicocampus.it., de Oriol Ocejo P; Endocrinolgy Unit. Fundación Jiménez Díaz Hospital, Madrid, Spain. Electronic address: patricia.oriol@quironsalud.es., Ortega Juaristi M; Endocrinolgy Unit. Fundación Jiménez Díaz Hospital, Madrid, Spain. Electronic address: MOrtega@fjd.es., Lorenzo O; Laboratory of Vascular Pathology and Diabetes. Fundación Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz. Universidad Autónoma. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) network, Madrid, Spain. Electronic address: OLorenzo@fjd.es., Buzzetti R; Department of Experimental Medicine, Sapienza University of Rome, Italy; Diabetes Unit, Policlinico Umberto I University Hospital, Rome, Italy. Electronic address: raffaella.buzzetti@uniroma1.it., Maddaloni E; Department of Experimental Medicine, Sapienza University of Rome, Italy; Diabetes Unit, Policlinico Umberto I University Hospital, Rome, Italy. Electronic address: ernesto.maddaloni@uniroma1.it. |
| Source: | Diabetes research and clinical practice [Diabetes Res Clin Pract] 2026 Sep; Vol. 239, pp. 113470. Date of Electronic Publication: 2026 Aug 06. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1993- : Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam : Elsevier Science Publishers B.V., c1985- |
| MeSH Terms: | Blood Glucose*/analysis , Diabetes Mellitus, Type 1*/drug therapy , Diabetes Mellitus, Type 1*/blood , Glycemic Control*/instrumentation , Glycemic Control*/methods , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/therapeutic use , Insulin*/administration & dosage , Insulin*/therapeutic use , Latent Autoimmune Diabetes in Adults*/drug therapy , Latent Autoimmune Diabetes in Adults*/blood , Insulin Infusion Systems*, Blood Glucose Self-Monitoring/instrumentation ; Continuous Glucose Monitoring/instrumentation ; Glycated Hemoglobin/analysis ; Adult ; Female ; Humans ; Male ; Middle Aged |
| Abstract: | Aims: To evaluate the effectiveness of the Medtronic MiniMed™ 780G Automated Hybrid Closed Loop System (AHCLS) in insulin-treated patients with latent autoimmune diabetes in adults (LADA). Methods: Continuous glucose monitoring (CGM) data and clinical records were collected from individuals with LADA using the MiniMed™ 780G. Participants were BMI-matched with individuals with LADA treated with multiple daily injections (MDI) + CGM and with people with type 1 diabetes (T1D) using either AHCLS or MDI + CGM. Multivariable regression models adjusted for age, sex, and diabetes duration were used to assess the effect of AHCLS on CGM metrics. Differences in treatment effect between LADA and T1D were evaluated through an interaction analysis. Results: AHCLS users showed higher time in range (TIR) than people on MDI (80 [71-87]% vs. 62 [50-75]%, p < 0.001) with no significant differences in the effect of AHCLS on TIR between people with LADA and T1D (p-interaction = 0.53). The percentages of patients meeting all CGM targets were 22.2% and 14.3% among people with LADA and T1D treated with MDI, and 54.4% and 77.8%, among those using AHCLS (p-value < 0.001; p-interaction = 0.39). Conclusions: MiniMed™ 780G markedly improves glycemic control in people with LADA, supporting AHCLS as an effective therapeutic strategy in this population. (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: EM: Abbott (consulting fees, travel grants, advisory board), Theras (travel grants); Medtronic (Institution). RB: Abbott (consulting fees, presentation honoraria, advisory board), Theras (consulting fees), Dexcom (consulting fees); Medtronic (Institution). MOJ: Medtronic (Institution). |
| Contributed Indexing: | Keywords: Closed loop systems; Continuous subcutaneous insulin infusion; Insulin therapy; LADA; Type 1 diabetes |
| Substance Nomenclature: | 0 (Blood Glucose) 0 (Glycated Hemoglobin) 0 (Hypoglycemic Agents) 0 (Insulin) |
| Entry Date(s): | Date Created: 20260806 Date Completed: 20260829 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1016/j.diabres.2026.113470 |
| PMID: | 42562181 |
| Database: | MEDLINE |
| ISSN: | 1872-8227 |
|---|---|
| DOI: | 10.1016/j.diabres.2026.113470 |