Academic Journal
Gastrointestinal manifestations of common variable immunodeficiency: what a gastroenterologist needs to be aware of.
| Τίτλος: | Gastrointestinal manifestations of common variable immunodeficiency: what a gastroenterologist needs to be aware of. |
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| Συγγραφείς: | Levy DM; Department of Medicine, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA., Meriwether M; Division of Gastroenterology Hepatology and Lynda K and David M Underwood Center for Digestive Health, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA., Schwartz MR; Department of Pathology and Genomic Medicine, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA., Bishu S; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Quigley EMM; Division of Gastroenterology Hepatology and Lynda K and David M Underwood Center for Digestive Health, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA. |
| Πηγή: | Expert review of gastroenterology & hepatology [Expert Rev Gastroenterol Hepatol] 2026 Aug; Vol. 20 (8), pp. 673-682. Date of Electronic Publication: 2026 Aug 17. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278199 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4132 (Electronic) Linking ISSN: 17474124 NLM ISO Abbreviation: Expert Rev Gastroenterol Hepatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs Ltd. |
| Ιατρικοί όροι (MeSH): | Common Variable Immunodeficiency*/diagnosis , Common Variable Immunodeficiency*/complications , Common Variable Immunodeficiency*/immunology , Common Variable Immunodeficiency*/therapy , Common Variable Immunodeficiency*/epidemiology , Gastrointestinal Diseases*/therapy , Gastrointestinal Diseases*/diagnosis , Gastrointestinal Diseases*/immunology , Gastrointestinal Diseases*/etiology , Gastrointestinal Diseases*/epidemiology, Humans ; Diagnosis, Differential ; Gastroenterologists ; Prognosis ; Predictive Value of Tests ; Risk Factors |
| Περίληψη: | Introduction: Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency disorder and, given its predilection to affect the gastrointestinal (GI) tract, will be encountered in the practice of a general gastroenterologist, as well as those with more focused interests. Areas Covered: Gastrointestinal and hepatic manifestations of CVID - their clinical presentation, endoscopic, imaging and pathological features. Also reviewed, in detail, diagnostic and therapeutic issues that the clinician may be confronted with in dealing with these disorders. Expert Opinion: Among the protean GI manifestations of CVID a predisposition to enteric infections, chronic gastritis, enteropathy and a form of inflammatory bowel disease feature prominently. Each poses diagnostic and therapeutic challenges; differentiation from celiac disease, Crohn's disease and ulcerative colitis may be challenging, emphasizing the need for awareness of the possibility of CVID when clinical features are atypical. The liver may also be involved, and the gastroenterologist needs to be especially aware of the higher prevalence of gastrointestinal cancer in this patient population. |
| Contributed Indexing: | Keywords: CVID; Celiac disease; Crohn’s disease; chronic gastritis; enteric infections; enteropathy; gastric cancer; inflammatory bowel disease |
| Entry Date(s): | Date Created: 20260806 Date Completed: 20260821 Latest Revision: 20260821 |
| Update Code: | 20260821 |
| DOI: | 10.1080/17474124.2026.2716136 |
| PMID: | 42557929 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1747-4132 |
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| DOI: | 10.1080/17474124.2026.2716136 |