Academic Journal
Repeatability of Foveal Sensitivity Measured Using Adaptive Optics Microperimetry.
| Τίτλος: | Repeatability of Foveal Sensitivity Measured Using Adaptive Optics Microperimetry. |
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| Συγγραφείς: | Govindasamy N; Bioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA, USA., Tuten WS; Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, CA, USA., Brainard DH; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA., Morgan JIW; Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania, Philadelphia, PA, USA. |
| Πηγή: | Translational vision science & technology [Transl Vis Sci Technol] 2026 Aug 03; Vol. 15 (8), pp. 3. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Association for Research in Vision and Ophthalmology Country of Publication: United States NLM ID: 101595919 Publication Model: Print Cited Medium: Internet ISSN: 2164-2591 (Electronic) Linking ISSN: 21642591 NLM ISO Abbreviation: Transl Vis Sci Technol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Rockville, Md. : Association for Research in Vision and Ophthalmology |
| Ιατρικοί όροι (MeSH): | Fovea Centralis*/physiology , Visual Field Tests*/methods , Visual Fields*/physiology , Optics and Photonics*, Sensory Thresholds/physiology ; Humans ; Reproducibility of Results ; Adult ; Female ; Male ; Psychophysics ; Photic Stimulation ; Young Adult |
| Περίληψη: | Purpose: To assess the within and between-session repeatability of foveal sensitivity measurements using adaptive optics (AO) microperimetry. Methods: Five normal-sighted participants underwent AO microperimetry testing (550-nm circular stimulus) at the preferred retinal locus across two sessions (2 months ± 2 weeks). Two psychophysical paradigms were used: quick estimation of threshold (QUEST) and method of constant stimuli (MOCS). Each paradigm employed both 1.05-arcmin2 and 30.4-arcmin2 stimulus sizes; stimuli were not stabilized in real time. Trial-by-trial responses were fit with a logistic psychometric function to obtain thresholds at a criterion of 78% seen. Thresholds were converted to sensitivity. Statistical comparisons were performed using paired-sample t-tests. Results: Sensitivities measured from QUEST and MOCS procedures were not significantly different (QUEST: 1.05 arcmin2, P = 0.36 for session 1 and P = 0.41 for session 2; MOCS: 30.4 arcmin2, P = 0.14 for session 1 and P = 0.12 for session 2). Data were thus combined across paradigms for tests of repeatability. Sensitivities for data split into two groups within session 1 and separately within session 2 were not significantly different (QUEST: 1.05 arcmin2, P = 0.34 for session 1 and P = 0.51 for session 2; MOCS: 30.4 arcmin2, P = 0.31 for session 1 and P = 0.27 for session 2). Overall, sensitivities across the two sessions were not significantly different (QUEST: 1.05 arcmin2, P = 0.06; MOCS: 30.4 arcmin2, P = 0.81). The coefficients of repeatability across sessions were 1.5 decibels (dB) and 0.4 dB for 1.05 arcmin2 and 30.4 arcmin2, respectively. Conclusions: Sensitivity measurements from AO microperimetry were repeatable within and across sessions. Translational Relevance: Results of the present study will guide future longitudinal studies of disease progression in detecting sensitivity changes using AO microperimetry. |
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| Grant Information: | P30 EY001583 United States EY NEI NIH HHS; R01 EY028601 United States EY NEI NIH HHS |
| Entry Date(s): | Date Created: 20260805 Date Completed: 20260805 Latest Revision: 20260826 |
| Update Code: | 20260826 |
| PubMed Central ID: | PMC13450651 |
| DOI: | 10.1167/tvst.15.8.3 |
| PMID: | 42554416 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2164-2591 |
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| DOI: | 10.1167/tvst.15.8.3 |